scholarly journals Effect of dietary protein, dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexane (HCH) on hepatic microsomal enzyme activity in rats

1985 ◽  
Vol 54 (3) ◽  
pp. 563-566 ◽  
Author(s):  
Girija Balakrishnan ◽  
M. Ramachandran ◽  
B. D. Banerjee ◽  
Q. Z. Hussain
Keyword(s):  
Enzyme Activity ◽  
G Protein ◽  
Dietary Protein ◽  
Enzyme Activities ◽  
Albino Rats ◽  
Microsomal Enzyme ◽  
Microsomal Enzymes ◽  
Nadph Cytochrome ◽  
Hepatic Microsomal Enzyme ◽  
Liver Microsomal Enzymes

1. Albino rats were fed on diets containing 30, 120 or 200 g protein/kg with or without the incorporation of dichlorodiphenyltrichloroethane (DDT) or hexachlorocyclohexane (HCH) at 100 mg/kg diet for 4 weeks.2. The activities of the liver microsomal enzymes NADPH-cytochrome reductase (EC 1.6.2.4), flavoprotein- linked monooxygenase (EC 1.14.14.1)and O-demethylase were significantly greater in animals fed on 120 and 200 g protein/kg diet compared with those fed on 30 g protein/kg diet.3. The inclusion of DDT or HCH at all protein intakes led to further significant rises in microsomal enzyme activities but the increases were much greater for animals receiving the 120 and 200 g protein/kg diets than for those receiving the 30 g protein/kg diet.4. The results imply that detoxification of DDT or HCH was carried out more effectively at the higher protein intakes.

Elevation of Serum Triacylglycerol Concentration in Association with Hepatic Microsomal Enzyme Induction after Treatment with Phenylbutazone and Diclofenac Sodium in Rats

1993 ◽  
Vol 84 (4) ◽  
pp. 387-390 ◽  
Author(s):  
Mahmoud M. Farag ◽  
Amel T. Hassib
Keyword(s):  
Adverse Effect ◽  
Enzyme Activity ◽  
Diclofenac Sodium ◽  
Microsomal Enzyme ◽  
Microsomal Enzymes ◽  
Hepatic Microsomal Enzyme ◽  
Triacylglycerol Concentration ◽  
The Relationship ◽  
Microsomal Enzyme Induction ◽  
Hepatic Microsomal Enzymes

1. The relationship between serum triacylglycerol concentration and hepatic microsomal enzyme activity was examined in rats. 2. Two groups of rats were injected with diclofenac sodium at doses of 2.5 and 5 mg day−1 kg−1. A third group was injected with phenylbutazone at a dose of 20 mg day−1 kg−1. The treatment was continued for 15 days and the rats were killed 24 h after the last dose. 3. In all drug-treated rats, the serum triacylglycerol concentration and the hepatic microsomal activities of aminopyrine N-demethylase and aniline hydroxylase were significantly increased as compared with the corresponding values in control rats. The correlations between the serum triacylglycerol concentrations and the activities of the two enzymes, as indices of the hepatic microsomal activity, were highly significant. 4. These results indicate that the possibility of hypertriglyceridaemia as an adverse effect of the induction of the hepatic microsomal enzymes after the administration of phenylbutazone and diclofenac sodium should be considered.

Increased Hepatic Microsomal Enzyme Activity After Surgery Under Halothane or Spinal Anesthesia

1985 ◽  
Vol 29 (4) ◽  
pp. 215
Author(s):  
S. LOFT ◽  
J. BOEL ◽  
A. KYST ◽  
B. RASMUSSEN ◽  
S. H. HANSEN ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Spinal Anesthesia ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme

scholarly journals The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning

1966 ◽  
Vol 100 (2) ◽  
pp. 564-571 ◽  
Author(s):  
AEM Mclean ◽  
EK Mclean
Keyword(s):  
Enzyme Activity ◽  
Carbon Tetrachloride ◽  
Protein Diet ◽  
Casein Diet ◽  
Microsomal Enzyme ◽  
Microsomal Enzymes ◽  
Lethal Effects ◽  
Carbon Tetrachloride Poisoning ◽  
Toxic Compound ◽  
Increased Sensitivity

1. Protein-depleted rats are resistant to the lethal effects of carbon tetrachloride. The LD(50) is 6.4ml./kg. in stock rats and 14.7ml./kg. in rats fed on protein-free diets. 2. Protein-depleted rats are resistant to carbon tetrachloride in its effect on the liver as judged by histology, accumulation of liver water, and plasma enzyme and bilirubin measurement. 3. The protection is present after feeding rats on a no-protein diet for 4 days. It is present after feeding rats on a 3%-casein diet, and partly found after feeding rats on a 6%-casein diet. 4. The activities of the microsomal enzymes that demethylate Pyramidon and hydroxylate benzopyrene in the liver fall by over 80% in rats fed on the no-protein diet for 4 days or more, or in rats fed on a 3%-casein diet. A 50% fall is found in rats fed on a 6%-casein diet. 5. A single dose of DDT or three doses of phenobarbitone cause increased microsomal enzyme activity in protein-depleted rats. 6. The animals are then sensitive to the lethal and liver-damaging effects of carbon tetrachloride. 7. DDT dosage also leads to increased sensitivity to carbon tetrachloride in rats fed on stock diets. 8. These findings support the hypothesis that carbon tetrachloride is metabolized by microsomal enzymes to form the true toxic compound.

Effect of cannabichromene on hepatic microsomal enzyme activity in the mouse

1983 ◽  
Vol 14 (3) ◽  
pp. 361-363 ◽  
Author(s):  
J.C. Kapeghian ◽  
A.B. Jones ◽  
J.C. Murphy ◽  
M.A. Elsohly ◽  
C.E. Turner
Keyword(s):  
Enzyme Activity ◽  
Microsomal Enzyme ◽  
Hepatic Microsomal Enzyme
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