Zosteriform Cutaneous Metastases arising from Adenocarcinoma of the Colon: Diagnostic Smear Cytology from Cutaneous Lesions

Cutaneous metastases from colorectal cancers are rare and are usually present on the abdominal wall or previous surgical incision sites. Remote cutaneous lesions have been reported, however, often occur in the setting of widespread metastatic disease including other visceral secondaries. We present a case of lower extremity cutaneous metastases as the first sign of metastatic disease in a patient with adenocarcinoma of the colon. This case illustrates that new skin lesions may be the initial presentation of metastatic disease in a patient with a history of cancer.

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Cutaneous metastases as a presenting sign of metastatic NSCLC

Journal of Surgical Case Reports ◽

10.1093/jscr/rjz279 ◽

2019 ◽

Vol 2019 (10) ◽

Cited By ~ 3

Author(s):

William T McSweeney ◽

Kimberley Tan

Keyword(s):

Asymptomatic Patient ◽

Smoking History ◽

Past Medical History ◽

Small Cell Lung ◽

Cutaneous Lesions ◽

Cutaneous Metastases ◽

Characteristic Appearance ◽

Internal Malignancy ◽

Metastatic Nsclc ◽

Underlying Malignancy

Abstract Cutaneous metastases are rare and often late signs of an internal malignancy; however, this can be the presenting sign in very rare cases. These typically have a characteristic appearance and distribution based on the underlying malignancy but can be difficult to distinguish from other malignant or benign dermatoses. We report a case of a 69-year-old female who presented for elective excision of two cutaneous, fast-growing lesions on the chest wall. The patient’s past medical history is significant for a 45-pack-year smoking history. Pre-operative chest radiograph revealed a right upper lobe mass, with the lesions ultimately representing cutaneous metastases of a non-small-cell lung cancer. Although cutaneous metastases have been reported, difficulty remains in distinguishing other causes of cutaneous lesions from cutaneous metastases in the predominantly asymptomatic patient.

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Diffuse Cutaneous Metastases as the Only Sign of Extranodal Tumor Spread in a Patient with Adenocarcinoma of the Colon

ISRN Surgery ◽

10.5402/2011/902971 ◽

2011 ◽

Vol 2011 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Serenella Civitelli ◽

Barbara Civitelli ◽

Jacopo Martellucci ◽

Gabriello Tanzini

Keyword(s):

Right Colon ◽

Cutaneous Metastases ◽

Tumor Spread ◽

Site Specific ◽

Poorly Differentiated Adenocarcinoma ◽

Anatomical Relationship ◽

Poorly Differentiated ◽

Adenocarcinoma Of The Colon ◽

The Right ◽

A Site

Cutaneous metastases from large bowel cancer are uncommon and are usually associated with organ involvement. Localization of lesions to the skin is mainly attributed to vascular and anatomical relationship, since most of them are seen in the abdominal wall or in a surgical scar. We report a 73-year-old woman in whom metastatic nodules from a poorly differentiated adenocarcinoma of the right colon developed throughout the skin (buttock, trunk, chest wall, arms, and neck) and remained the only sign of extranodal tumor spread until patient's death, seven months later. This unusual behaviour suggests that localization of neoplastic cells to the skin may be a site-specific process, determined by adhesion molecules and/or by growth factors found at that site.

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Prostate adenocarcinoma and cutaneous metastases

Journal of Clinical Urology ◽

10.1177/2051415820954755 ◽

2020 ◽

pp. 205141582095475

Author(s):

Jeff John ◽

Tanya Wantenaar ◽

John Lazarus ◽

Ken Kesner

Keyword(s):

Prostate Cancer ◽

Skin Lesions ◽

Prostate Adenocarcinoma ◽

Cutaneous Lesions ◽

Cutaneous Metastases ◽

Primary Malignancy ◽

Level Of Evidence ◽

History Of ◽

Adenocarcinoma Of The Prostate ◽

Nodular Lesions

Prostate cancer is the second most frequently diagnosed cancer in men and the fifth leading cause of mortality worldwide. Men of African descent with prostate adenocarcinoma tend to present late with advanced, aggressive and often metastatic disease. Cutaneous metastases are extremely rare, with the incidence reported to be as low as 0.36%. We report a case of prostate adenocarcinoma with cutaneous metastases. A 69-year-old African male known to the urology unit, with metastatic adenocarcinoma of the prostate, presented with a two-week history of pale-to-purple large nodular lesions on the skin of his left hemiscrotum and smaller nodules on the penile shaft. Punch biopsies of the scrotal nodules revealed metastatic prostate adenocarcinoma. Bilateral orchidectomy and excision of the cutaneous lesions were performed. Although cutaneous metastases are rare, more so in patients with adenocarcinoma of the prostate, any skin lesions in patients with a known primary malignancy should raise a suspicion of metastasis. All physicians should therefore have a low threshold for the biopsy of any unusual skin lesion in patients with known prostate cancer. Level of evidence: 5.

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A Rare Presentation of Cutaneous Metastases in Advanced Lung Adenocarcinoma

Journal of Clinical and Health Sciences ◽

10.24191/jchs.v5i2.11125 ◽

2020 ◽

Vol 5 (2) ◽

pp. 75

Author(s):

Liyana Dhamirah Aminuddin ◽

Sabrina Ab Wahab ◽

Suhaili Shariffudin ◽

Tarita Taib

Keyword(s):

Lung Cancer ◽

Lung Adenocarcinoma ◽

Primary Lung Cancer ◽

Cutaneous Lesions ◽

Cutaneous Metastases ◽

Primary Malignancy ◽

Rare Presentation ◽

Thyroid Transcription Factor 1 ◽

Metastatic Lung ◽

Systemic Symptoms

Patients with lung cancer may present with respiratory and systemic symptoms. However, cutaneous metastases from primary lung cancer is a rare phenomenon, especially in women, that signifies a poor prognosis. This paper reported a case regarding a 71-year-old woman who was first presented with a cutaneous nodule over the year. Her condition was further progressed to multiple lesions on the back and abdomen, dyspnoea, haemoptysis and weight loss. The results of the skin lesion biopsy exhibited metastatic lung adenocarcinoma with positive immunohistochemistry for thyroid transcription factor 1 (TTF1) and cytokeratin 7 (CK7). Computed tomography (CT) scan was conducted, and it revealed a left upper lobe lung mass. The patient was subsequently scheduled for additional management, but she had succumbed to complications of pulmonary embolism before the necessary interventions could be provided. In this particular case presentation, the biopsy of cutaneous lesions obtained had revealed an undiagnosed primary malignancy.

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Cutaneous Metastasis in the Setting of Both Colon and Breast Primary Malignancies

Case Reports in Gastrointestinal Medicine ◽

10.1155/2020/8852459 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Mary Junak ◽

Hunter Jecius ◽

Jennifer Erdrich ◽

Shiro Kikuchi

Keyword(s):

Ductal Carcinoma ◽

Case Reports ◽

Colon Adenocarcinoma ◽

The United States ◽

Punch Biopsy ◽

Left Breast ◽

Cutaneous Metastasis ◽

Cutaneous Lesions ◽

Cutaneous Metastases ◽

Colonic Primary

Colorectal cancer (CRC) is the third most diagnosed cancer in the United States, and many patients unfortunately have metastases at the time of their diagnosis. Cutaneous metastases of CRC have been reported in few journals and primarily as case reports due to their rarity. Here, we present the case of an 83-year-old woman with recently resected colon cancer, T4aN1bMx stage IIIB. She presented to our clinic for evaluation of a right midback mass, and a punch biopsy revealed dermal involvement by invasive, poorly differentiated carcinoma with epidermoid features. The mass was excised, and we ordered a PET scan in search of the primary tumor, which at that time was suspected to be of skin cancer origin. Surprisingly, this revealed a second malignancy triple-negative invasive ductal carcinoma of the left breast. The back mass stained positive for CK20, which was compatible with a metastasis from a colonic primary. After initially declining adjuvant therapy, the patient completed one cycle of capecitabine and oxaliplatin, which she tolerated poorly. She continued to further decline, developed widespread cutaneous metastases, and went home on hospice. Cutaneous lesions are an exceedingly rare site of metastasis for colon adenocarcinoma, and their clinical presentation can vary widely. It is important for providers to investigate any new skin lesion in a patient with a recent or remote history of malignancy, even if there were no sites of distant metastasis at initial diagnosis.

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