scholarly journals Cutaneous Metastasis in the Setting of Both Colon and Breast Primary Malignancies

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Mary Junak ◽  
Hunter Jecius ◽  
Jennifer Erdrich ◽  
Shiro Kikuchi
Keyword(s):  
Ductal Carcinoma ◽  
Case Reports ◽  
Colon Adenocarcinoma ◽  
The United States ◽  
Punch Biopsy ◽  
Left Breast ◽  
Cutaneous Metastasis ◽  
Cutaneous Lesions ◽  
Cutaneous Metastases ◽  
Colonic Primary

Colorectal cancer (CRC) is the third most diagnosed cancer in the United States, and many patients unfortunately have metastases at the time of their diagnosis. Cutaneous metastases of CRC have been reported in few journals and primarily as case reports due to their rarity. Here, we present the case of an 83-year-old woman with recently resected colon cancer, T4aN1bMx stage IIIB. She presented to our clinic for evaluation of a right midback mass, and a punch biopsy revealed dermal involvement by invasive, poorly differentiated carcinoma with epidermoid features. The mass was excised, and we ordered a PET scan in search of the primary tumor, which at that time was suspected to be of skin cancer origin. Surprisingly, this revealed a second malignancy triple-negative invasive ductal carcinoma of the left breast. The back mass stained positive for CK20, which was compatible with a metastasis from a colonic primary. After initially declining adjuvant therapy, the patient completed one cycle of capecitabine and oxaliplatin, which she tolerated poorly. She continued to further decline, developed widespread cutaneous metastases, and went home on hospice. Cutaneous lesions are an exceedingly rare site of metastasis for colon adenocarcinoma, and their clinical presentation can vary widely. It is important for providers to investigate any new skin lesion in a patient with a recent or remote history of malignancy, even if there were no sites of distant metastasis at initial diagnosis.

scholarly journals 354. The Epidemiology and Clinical Features of Acanthamoeba Disease in the United States, 1956–2018

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S246-S246
Author(s):  
Kevin O’Laughlin ◽  
Jennifer R Cope ◽  
Zachary A Marsh
Keyword(s):  
United States ◽  
Case Reports ◽  
The United States ◽  
Severe Illness ◽  
People Living With Hiv ◽  
Cutaneous Lesions ◽  
Free Living ◽  
Organ Systems ◽  
Free Living Ameba ◽  
Soil And Water

Abstract Background Acanthamoeba is a free-living ameba found worldwide in soil and water that can cause severe illness. Transmission is thought to be through the skin, eyes, or lungs; Acanthamoeba can cause disseminated infection (Acanthamoeba disease) in addition to the more widely recognized Acanthamoeba keratitis. Infections however are rare, and only case reports or small case series have been published. We review Acanthamoeba disease cases from the Centers for Disease Control and Prevention (CDC) free-living ameba registry to characterize the disease in the United States. Methods CDC maintains a free-living ameba (FLA) registry of laboratory-confirmed Acanthamoeba cases (excluding keratitis) sourced from published case reports, CDC case report forms, and CDC laboratory results. SAS© version 9.4 software was used to calculate descriptive statistics and frequencies. Results We identified 163 cases of Acanthamoeba disease between 1956 and 2018. Of cases with documented outcome, 85% were fatal (105/124). Most (88%) cases were in patients who were immunocompromised (136/155): 66 people living with HIV (of whom 49 were classified as having AIDS); 33 recipients of organ transplantation; 30 people diagnosed with malignancy. The most common manifestation of disease was encephalitis (49%). Other clinical presentations included cutaneous lesions (20%) and rhinosinusitis (6%); 40 cases involved multiple organ systems. Median patient age was 42 years (range 0–83 years). Males accounted for 71% (114/160) of cases. California (29) and Texas (14) had the most case reports; 30 other states reported cases. The source of exposure was unknown in most cases (75%); soil and water were documented in 14 and 17 cases, respectively. Conclusion Acanthamoeba disease in the United States is primarily characterized by encephalitis and cutaneous lesions that affect predominately immunocompromised individuals. Acanthamoeba as a cause of encephalitis in immunocompromised patients should be considered by clinicians, which may lead to earlier diagnosis and treatment. Disclosures All Authors: No reported disclosures

scholarly journals Cutaneous Metastasis of Prostate Adenocarcinoma: A Rare Presentation of a Common Disease

2021 ◽  
Vol 9 ◽  
pp. 232470962199076
Author(s):  
Alexander Dills ◽  
Okechukwu Obi ◽  
Kevin Bustos ◽  
Jesse Jiang ◽  
Shweta Gupta
Keyword(s):  
Prostate Cancer ◽  
Serine Proteases ◽  
Cancer Genetics ◽  
Performance Status ◽  
Distant Metastases ◽  
The United States ◽  
Cutaneous Metastasis ◽  
Common Disease ◽  
Cutaneous Metastases ◽  
Rare Presentation

Prostate cancer is the most common cancer affecting men in the United States and the second greatest cause of cancer-related death. Metastases usually occur to bone followed by distant lymph nodes and then viscera. Cutaneous metastases are extremely rare. Their presence indicates advanced disease and a poor prognosis. As they are highly variable in appearance and may mimic a more benign process, biopsy is essential for identification. Serine proteases, particularly human tissue kallikreins, may play an important role in promoting metastasis and facilitate infiltration of the skin. Individual cancer genetics may predispose to more aggressive cancer and thus earlier and more distant metastases. In this article, we report our case of a 67-year-old man with a 4-year history of castrate-resistant prostate cancer with cutaneous metastases confirmed by histology. Despite multiple lines of systemic therapy, the patient suffered progressive disease with worsening performance status and was enrolled in hospice.

scholarly journals Multiple Cutaneous Metastases as Initial Presentation in Advanced Colon Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Sudheer Nambiar ◽  
Asha Karippot
Keyword(s):  
Advanced Colorectal Cancer ◽  
Clinical Manifestations ◽  
Colon Adenocarcinoma ◽  
Distant Metastases ◽  
Cutaneous Metastasis ◽  
Ascending Colon ◽  
Visceral Metastasis ◽  
Cutaneous Metastases ◽  
Advanced Colon Cancer ◽  
Metastatic Lesions

Skin metastases from advanced colorectal cancer are relatively rare and occur most often when the cancer is advanced, following the spread to other organs. Cutaneous metastases occur in about 3% of advanced colorectal cancers. We present an extremely rare case of a 68-year-old woman with advanced ascending colon adenocarcinoma that presented with multiple rapidly progressing painless cutaneous metastatic lesions with no other distant metastases. Of all the tumors, breast cancer most commonly spreads as cutaneous metastasis is followed by lung, colorectal, renal, ovarian, and bladder cancers. Cutaneous metastases can present in a variety of clinical manifestations, such as a rapidly growing painless dermal or subcutaneous nodule with intact overlying epidermis or as ulcers. In cases where the cutaneous deposit is isolated, as in visceral metastasis, there is a role for radical management such as wide local excision and reconstruction. In our patient, since she had multiple cutaneous metastases she began treatment with palliative systemic combination chemotherapy.

scholarly journals A peculiar case of cancer en cuirasse in adenocarcinoma rectum

2020 ◽  
Vol 6 (5) ◽  
pp. 190
Author(s):  
Parul Gupta ◽  
Ashish Nigam ◽  
Anil K. Dhull ◽  
Arpit Mittal
Keyword(s):  
Case Reports ◽  
Young Female ◽  
Cutaneous Metastasis ◽  
Primary Adenocarcinoma ◽  
Cutaneous Metastases ◽  
Elderly Individuals ◽  
Morphological Variant ◽  
Rare Phenomenon ◽  
Sixth Decade ◽  
Peculiar Case

<p>Cancer en cuirasse in a case of primary adenocarcinoma rectum is an exceedingly rare phenomenon which is scarcely seen in isolated case reports only. It is a specific morphological variant of cutaneous metastasis characterised by diffuse induration and oedema of cutis which is studded with carcinomatous lesions. Cutaneous metastases often occur in elderly individuals in their sixth decade or later. Herein we present a case of carcinoma en cuirasse arising in a young female who was operated for adenocarcinoma rectum.</p>

scholarly journals Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 954
Author(s):  
Paola Parente ◽  
Davide Ciardiello ◽  
Luca Reggiani Bonetti ◽  
Vincenzo Famiglietti ◽  
Gerardo Cazzato ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Reports ◽  
Rare Event ◽  
Case Series ◽  
Cutaneous Metastasis ◽  
Cutaneous Lesions ◽  
Primary Malignancy ◽  
Visceral Metastases ◽  
History Of ◽  
Colorectal Cancer Patients

Cutaneous metastasis from solid tumors is a rare event and usually represents a late occurrence in the natural history of an advanced visceral malignancy. Rarely, cutaneous metastasis has been described in colorectal cancer patients. The most frequent cutaneous site of colorectal metastasis is the surgical scar in the abdomen following the removal of the primary malignancy, followed by the extremities, perineum, head, neck, and penis. Metastases to the thigh and back of the trunk are anecdotical. Dermatological diagnosis of cutaneous metastasis can be quite complex, especially in unusual sites, such as in the facial skin or thorax and in cases of single cutaneous lesions since metastasis from colorectal cancer is not usually the first clinical hypothesis, leading to misdiagnosis. To date, due to the rarity of cutaneous metastasis from colorectal cancer, little evidence, most of which is based on case reports and very small case series, is currently available. Therefore, a better understanding of the clinic-pathological characteristics of this unusual metastatic site represents an unmet clinical need. We present a large series of 29 cutaneous metastases from colorectal cancer with particular concerns regarding anatomic localization and the time of onset with respect to primitive colorectal cancer and visceral metastases.

scholarly journals Postirradiation Multiple Minute Digitate Porokeratosis: Case Report

2018 ◽  
Vol 75 (4) ◽  
pp. 425-428
Author(s):  
Joana Lima ◽  
Marta Sousa ◽  
Pedro Andrade
Keyword(s):  
Ductal Carcinoma ◽  
Beta Blockers ◽  
Rare Condition ◽  
Venous Access ◽  
Left Breast ◽  
Breast Adenocarcinoma ◽  
Complete Regression ◽  
Malignant Tumours ◽  
Cutaneous Lesions ◽  
Drug Induced

Docetaxel is a second-generation taxane commonly used in the treatment of advanced malignant tumours such as breast adenocarcinoma. We describe the case of a 67-year-old female undergoing adjuvant chemotherapy with docetaxel for invasive ductal carcinoma of the left breast presenting with typical psoriatic lesions on the dorsum and limbs - the most representative of them arising close to the venous access for docetaxel infusion. No personal or family history of psoriasis was reported. The patient started and maintained treatment with oral acitretin and topical betamethasone diproprionate/calcipotriol for nearly eight months, with almost complete regression of cutaneous lesions. Drug-induced psoriasis is a rare condition. The most commonly reported drugs include beta-blockers, interferon and antimalarials. In this case we demonstrate that docetaxel should be included in the group of drugs that can potentially induce psoriasis.

A case of cutaneous metastatic adenosquamous carcinoma of the cervix

2019 ◽  
Vol 3 (4) ◽  
pp. 271-274
Author(s):  
Taylor Shea Novice ◽  
David Oberlin ◽  
Chauncey McHargue
Keyword(s):  
Cervical Carcinoma ◽  
Poor Prognosis ◽  
Adenosquamous Carcinoma ◽  
Average Length ◽  
Punch Biopsy ◽  
Cutaneous Metastasis ◽  
African American Female ◽  
Cutaneous Metastases ◽  
History Of ◽  
Disease Specific

Introduction:Cutaneous metastasis of cervical carcinoma is very rare, with a reported incidence of .1 to 2%. The adenosquamous carcinoma subtype has been reported the least.3-5 We present a case report of ulceronodular cutaneous metastasis of adenosquamous carcinoma of the cervix.Case Description:A 50-year-old African American female with an eleven-year history of metastatic adenosquamous carcinoma of the cervix presented to the emergency department with an asymptomatic rash in her groin for one-month duration. On physical exam, there were hyperpigmented to violaceous papulonodules across the mons pubis and three ulcerated plaques of the left mons pubis. Punch biopsy was consistent with metastases of cervical adenosquamous carcinoma. No disease specific interventions were taken, and the patient passed away five weeks later.Discussion:Cervical cancer rarely metastasizes to the skin, with a reported incidence of .1 to 2%. Among the subtypes, cutaneous metastasis of cervical adenosquamous carcinoma has been reported the least. In a review of 1185 cases of cervical cancer, Imachi et al found that only 15 cases spread cutaneously, none of which were adenosquamous carcinoma.5 Cutaneous metastases of cervical carcinoma predict a poor prognosis, with an average length of survival of three months.6Our patient developed cutaneous metastases eleven years after diagnosis, which is to our knowledge the longest reported interval from initial diagnosis to development of cutaneous metastases. Although rare, it is important to recognize cutaneous metastases of adenosquamous carcinoma of the cervix as it predicts a poor prognosis and treatment has not been shown to improve outcomes.

scholarly journals Gestational gigantomastia: A case series

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Camila Vitola Pasetto ◽  
Natalia de Souza Costa ◽  
Isabela do Prado Nascimento ◽  
Marcos Daniel Weffort ◽  
Vinicius Milani Budel
Keyword(s):  
Inflammatory Process ◽  
Ductal Carcinoma ◽  
Case Reports ◽  
Case Series ◽  
Intraoperative Radiotherapy ◽  
Orange Peel ◽  
Left Breast ◽  
Breast Ultrasound ◽  
Relative Reduction ◽  
The Right

Introduction: Gestational gigantomastia (GG) is a rare condition known for the massive growth of one or both breasts during pregnancy. Objectives: to describe three cases of GG in patients assisted Hospital de Clínicas do Paraná. Case Reports: Case 1 ‒ Twenty-four year old pregnant woman, of 9 weeks, presented with mastalgia and increasing breast volume associated with phlogistic signs and orange peel-like skin. Breast ultrasound showed diffuse inflammatory process. A biopsy was performed and showed ductal ectasia and stromal fibroadenomatoid changes. On the 20th week, she was hospitalized with fever, voluminous breasts and drainage of purulent secretion and long ulcers in the inframammary fold. She was administered antibiotics and local care. The choice was to interrupt the pregnancy of 33 weeks. She presented with relative reduction of the breasts and breastfed, but had severe psychological problems caused by the aesthetic dissatisfaction. Case 2 ‒ Eighteen-year old patient presented with infiltrating ductal breast carcinoma in the right breast, treated with sectorectomy, with sentinel lymph node and conventional radiotherapy. After one year of follow-up, ductal carcinoma in situ (DCIS) was diagnosed in the left breast, being submitted to sectorectomy and intraoperative radiotherapy. Two years after DCIS, she became pregnant and presented with GG only in the left breast, with remarkable asymmetry and skin edema. After the Cesarean section, breastfeeding was normal on the GG side, but not on the right side, due to a sequel from total radiotherapy. Case 3 ‒ Twenty-two year old pregnant women, of 12 weeks, presented with mastalgia and exaggerated growth of the breasts, with and orange peel-like skin. Breast ultrasound showed bilateral inflammatory process. On the 15th week, she presented with bleeding ulcers, right breast with latero-lateral diameter of 48 cm, and craniocaudal diameter of 56 cm, and left breast with 49 cm and 58 cm, respectively. Due to the fast and progressive growth of the breasts, with difficulties to breath, major venous and lymph stasis and extensive skin ulceration/maceration, with risk of infection, the patient and relatives agreed on conducting a therapeutic abortion, followed by a reduction mammoplasty. Discussion: It is a rare disease, and its etiology remains unknown. Medicinal therapy seems to be first option, but it is often necessary to complement it with a surgical procedure. Conclusions: GG is a pathology of great morbidity, with tendency to recede in the puerperium. In case it is not possible to wait, the recommendation is to intervene in the pregnancy.

scholarly journals Synchronous Occurrence of Primary Breast Carcinoma and Primary Colon Adenocarcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Gurkan Yetkin ◽  
Fevzi Celayir ◽  
Ismail Ethem Akgun ◽  
Ramazan Ucak
Keyword(s):  
Adjuvant Chemotherapy ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Colon Adenocarcinoma ◽  
Right Hemicolectomy ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Hepatic Flexure ◽  
Breast Invasive Ductal Carcinoma ◽  
Primary Colon

A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast. Invasive ductal carcinoma was detected in core needle biopsy samples from lesions. In the multidisciplinary council consisting of oncologist, pathologist, radiologist, and general surgery specialist, it was decided to perform breast operation first and then colon operation, followed by adjuvant chemotherapy. In the first operation, left total mastectomy and sentinel lymph node biopsy were performed. One week after her initial operation, the patient underwent right hemicolectomy. After operations, the patient did not develop postoperative complications and was sent to medical oncology department for adjuvant chemotherapy.

scholarly journals Croatia’s First Experiences in Cytological Diagnosis of High-Grade Ductal Carcinoma in Situ of the Breast: Case Reports and a Review of Literature

2021 ◽  
Vol 6 (6) ◽  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Case Reports ◽  
Nipple Discharge ◽  
Left Breast ◽  
Cytological Diagnosis ◽  
High Grade ◽  
Morphological Criteria

Cases here presented are also first Croatia’s experiences in the cytological diagnosis of breast ductal carcinoma in situ (DCIS). The first patient was a 64-year-old woman, by imaging methods with a wide area of suspect microcalcifications in the left breast lower medial quadrant and abundant, dense, yellow-greyish discharge of the same mammilla and second was a 65-year-old woman with an equivocal lesion in left breast lower lateral quadrant. Morphological findings of both aspirates and nipple discharge from the first patient were practically the same - moderately to highly cellular, with 3D solid aggregates, monolayer sheets and many scattered single clearly malignant cells of large - mainly >5x the diameter of an erythrocyte, round-to-ovaloid, manifestly irregular nuclei, dark blue, polymorphous, often multiple (macro)nucleoli, irregular nuclear outlines and dense, more basophilic, mostly scant cytoplasms arranged in syncytium–like structures. “Dirty” background was overfull of comedo necrosis and dark grayish, sharp, irregular microcalcifications. Cytological diagnosis in both cases was DCIS, high-grade, comedo type. Histopathologically first tumor was big, 6 cm large, estimated as comedo carcinoma with microinvasion focuses not bigger than 1 mm, but without signs of angioinvasion, while the second tumor was smaller, 0.6 cm with wide ducts fully with large polymorphic malignant epithelial cells, central comedo necrosis, cancerisation of some lobules but with the intact basement membrane. It was pure high-grade DCIS, comedo type. Presented cases completely reflect to date knowledge about cytological diagnostic of high-grade DCIS; include necessary morphological criteria - highgrade nuclear atypia, an abundance of comedo necrosis and microcalcifications, confirm our limitation in the presumption of invasion status with large lesion extent, but also prove that cytology is the unquestionably reliable in breast morphological diagnostic, even in such sophisticated and demanding pathological issue like DCIS.

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