The impact of chronic rhinosinusitis on long-term survival in lung transplantation recipients

Abstract OBJECTIVES The aim of this study was to evaluate the impact of institutional volume on long-term outcomes following lung transplantation (LTx) in the USA. METHODS Adults undergoing LTx were identified in the United Network for Organ Sharing registry. Patients were divided into equal size tertiles according to the institutional volume. All-cause mortality following LTx was evaluated using the risk-adjusted multivariable Cox regression and the Kaplan–Meier analyses, and compared between these volume cohorts at 3 points: 90 days, 1 year (excluding 90-day deaths) and 10 years (excluding 1-year deaths). Lowess smoothing plots and receiver-operating characteristic analyses were performed to identify optimal volume thresholds associated with long-term survival. RESULTS A total of 13 370 adult LTx recipients were identified. The mean annual centre volume was 33.6 ± 20.1. After risk adjustment, low-volume centres were found to be at increased risk for 90-day mortality, [hazard ratio (HR) 1.56, P < 0.001], 1-year mortality excluding 90-day deaths (HR 1.46, P < 0.001) and 10-year mortality excluding 1-year deaths (HR 1.22, P < 0.001). These findings persisted when the centre volume was modelled as a continuous variable. The Kaplan–Meier analysis also demonstrated significant reductions in survival at each of these time points for low-volume centres (each P < 0.001). The 10-year survival conditional on 1-year survival was 37.4% in high-volume centres vs 28.0% in low-volume centres (P < 0.001). The optimal annual volume threshold for long-term survival was 26 LTx/year. CONCLUSIONS The institutional volume impacts long-term survival following LTx, even after excluding deaths within the first post-transplant year. Identifying the processes of care that lead to longer survival in high-volume centres is prudent.

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Management of Pseudomonas aeruginosa Infection After Lung Transplantation Across the UK and the Impact on Long-Term Survival

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2017.01.1537 ◽

2017 ◽

Vol 36 (4) ◽

pp. S322

Author(s):

T.C. Gan ◽

A.E. Cockburn ◽

H. Yung ◽

E. Karimi ◽

L. Dirmantaite ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Lung Transplantation ◽

Term Survival ◽

Long Term Survival ◽

Pseudomonas Aeruginosa Infection ◽

The Uk ◽

The Impact

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The Impact of Pretransplant Mechanical Ventilation on Short- and Long-Term Survival After Lung Transplantation

American Journal of Transplantation ◽

10.1111/j.1600-6143.2011.03684.x ◽

2011 ◽

Vol 11 (10) ◽

pp. 2197-2204 ◽

Cited By ~ 36

Author(s):

J. P. Singer ◽

P. D. Blanc ◽

C. Hoopes ◽

J. A. Golden ◽

J. L. Koff ◽

...

Keyword(s):

Mechanical Ventilation ◽

Lung Transplantation ◽

Term Survival ◽

Long Term Survival ◽

Short And Long Term ◽

The Impact

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Variation in center-level frailty burden and the impact of frailty on long-term survival in patients undergoing elective repair for abdominal aortic aneurysms

Journal of Vascular Surgery ◽

10.1016/j.jvs.2019.01.074 ◽

2020 ◽

Vol 71 (1) ◽

pp. 46-55.e4 ◽

Cited By ~ 9

Author(s):

Elizabeth L. George ◽

Rui Chen ◽

Amber W. Trickey ◽

Benjamin S. Brooke ◽

Larry Kraiss ◽

...

Keyword(s):

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Term Survival ◽

Long Term Survival ◽

Abdominal Aortic ◽

Elective Repair ◽

The Impact

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Long-Term Tacrolimus Blood Trough Level and Patient Survival in Adult Liver Transplantation

Journal of Personalized Medicine ◽

10.3390/jpm11020090 ◽

2021 ◽

Vol 11 (2) ◽

pp. 90

Author(s):

Chih-Yang Hsiao ◽

Ming-Chih Ho ◽

Cheng-Maw Ho ◽

Yao-Ming Wu ◽

Po-Huang Lee ◽

...

Keyword(s):

Patient Survival ◽

Trough Level ◽

Medical Center ◽

Term Survival ◽

Blood Concentrations ◽

Long Term Survival ◽

Tacrolimus Level ◽

Cox's Model ◽

The Impact

Tacrolimus is the most widely used immunosuppressant in liver transplant (LT) patients. However, the ideal long-term target level for these patients is unknown. This retrospective study aimed to investigate the impact of tacrolimus blood concentration five years after LT on long-term patient survival outcomes in adult LT recipients. Patients who underwent LT between January 2004 and July 2014 at a tertiary medical center were included in this study (n = 189). The mean tacrolimus blood concentrations of each patient during the fifth year after LT were recorded and the overall survival rate was determined. A multivariate analysis of factors associated with long-term survival was conducted using a Cox’s model. The median follow-up period was 9.63 years, and 144 patients (76.2%) underwent live donor LT. Sixteen patients died within 5 years of LT. In the Cox’s model, patients with a mean tacrolimus blood trough level of 4.6–10.2 ng/mL had significantly better long-term survival than those with a mean tacrolimus blood trough level outside this range (estimated hazard ratio = 4.76; 95% confidence interval: 1.34–16.9, p = 0.016). Therefore, a tacrolimus level no lower than 4.6 ng/mL would be recommended in adult LT patients.

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Long-Term Survival After Lung Transplantation in Patients with Silicosis and Other Occupational Lung Disease

Lung ◽

10.1007/s00408-015-9781-z ◽

2015 ◽

Vol 193 (6) ◽

pp. 927-931 ◽

Cited By ~ 6

Author(s):

Don Hayes ◽

Kaitlyn T. Hayes ◽

Hunter C. Hayes ◽

Joseph D. Tobias

Keyword(s):

Lung Transplantation ◽

Lung Disease ◽

Term Survival ◽

Long Term Survival ◽

Occupational Lung Disease

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Factors indicative of long-term survival after lung transplantation: A review of 836 10-year survivors

Yearbook of Pulmonary Disease ◽

10.1016/j.ypdi.2010.11.014 ◽

2011 ◽

Vol 2011 ◽

pp. 178-179

Author(s):

J.R. Maurer

Keyword(s):

Lung Transplantation ◽

Term Survival ◽

Long Term Survival

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Clinical and Oncological Value of Preoperative BMI in Gastric Cancer Patients: A Single Center Experience

Gastroenterology Research and Practice ◽

10.1155/2015/810134 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Costantino Voglino ◽

Giulio Di Mare ◽

Francesco Ferrara ◽

Lorenzo De Franco ◽

Franco Roviello ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Blood Proteins ◽

Term Survival ◽

Long Term Survival ◽

Single Center Experience ◽

Group B ◽

Gastric Cancer Patients ◽

The Impact

Introduction. The impact of preoperative BMI on surgical outcomes and long-term survival of gastric cancer patients was investigated in various reports with contrasting results.Materials & Methods. A total of 378 patients who underwent a surgical resection for primary gastric cancer between 1994 and 2011 were retrospectively studied. Patients were stratified according to BMI into a normal group (<25, group A), an overweight group (25–30, group B), and an obesity group (≥30, group C). These 3 groups were compared according to clinical-pathological characteristics, surgical treatment, and long-term survival.Results. No significant correlations between BMI and TNM (2010), UICC stage (2010), Lauren’s histological type, surgical results, lymph node dissection, and postoperative morbidity and mortality were observed. Factors related to higher BMI were male genderP<0.05, diabetesP<0.001, and serum blood proteinsP<0.01. A trend to fewer lymph nodes retrieved during gastrectomy with lymphadenectomy in overweight patients (B and C groups) was observed, although not statistically significant. There was no difference in overall survival or disease-specific survival between the three groups.Conclusion. According to our data, BMI should not be considered a significant predictor of postoperative complications or long-term result in gastric cancer patients.

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