Gas-Liquid Chromatographic Determination of Almitrine in Rat Intestinal Fluid Using Flame Ionization Detection

1992 ◽  
Vol 25 (10) ◽  
pp. 1843-1850 ◽  
Author(s):  
R. Geary ◽  
S. Stavchansky
Keyword(s):  
Chromatographic Determination ◽  
Flame Ionization Detection ◽  
Intestinal Fluid ◽  
Ionization Detection ◽  
Flame Ionization ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

scholarly journals Liquid Chromatographic Determination of Sugar Alcohols in Beverages and Foods after Nitrobenzoylation

1999 ◽  
Vol 82 (1) ◽  
pp. 134-140 ◽  
Author(s):  
Shuko Nojiri ◽  
Kazuo Saito ◽  
Nobuo Taguchi ◽  
Mitsuo Oishi ◽  
Toshio Maki
Keyword(s):  
Mobile Phase ◽  
Chromatographic Determination ◽  
Flame Ionization Detection ◽  
Sugar Alcohols ◽  
Flame Ionization ◽  
Phase Calibration ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Refractive Index Detection

Abstract Use of p-nitrobenzoyl chloride (PNBC) to form an ultraviolet-absorbing derivative was attempted to determine the sugar alcohols meso-erythritol, xyli-tol, D-sorbitol,and D-mannitol by liquid chromatography (LC). LC determination of derivatives was performed on an ODS column with acetonitrile–water (65 + 35) as mobile phase. Calibration curves were linear in the concentration range 0.01–100 μg/mL. Method sensitivity is 10 to 1000 times higher than that of LC with refractive index detection and gas chromatography with flame ionization detection. Recoveries of sugars added to various foods at 0.1 and 1% ranged from 91 to 102% for meso-erythritol, 75 to 115% for xylitol, 81 to 105% for D-sorbitol, and 81 to 108% for D-mannitol.

Gas-Liquid Chromatographic Determination of Tetradif on Technical and Formulations: Collaborative Study

1981 ◽  
Vol 64 (4) ◽  
pp. 829-832
Author(s):  
Bram Van Rossum ◽  
Albertus Martijn ◽  
James E Launer ◽  
◽  
E C Calamita ◽  
...  
Keyword(s):  
Collaborative Study ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Flame Ionization ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract The gas-liquid chromatographic determination of tetradifon technical and formulations was collaboratively studied in duplicate with 12 laboratories. Six samples were dissolved in dichloroethane with n-hexacosane as the internal standard, chromatographed on a column of 3% SE-52, and detected by flame ionization. The average coefficients of variation were 1.2% for the 2 technical samples, 1.6% for the 2 wettable powders, and 1.5% for the 2 emulsifiable concentrates. The method has been adopted official first action.

Gas-Liquid Chromatographic Determination of Pyridazinones in Technical Products and Formulations

1978 ◽  
Vol 61 (1) ◽  
pp. 161-163
Author(s):  
Giuseppe Cellerino ◽  
Mariarosa Re
Keyword(s):  
Internal Standard ◽  
Standard Technique ◽  
Chromatographic Determination ◽  
Gas Liquid Chromatography ◽  
Flame Ionization ◽  
Selective Detector ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Technical Products

Abstract Simultaneous determination of the active ingredient and of by-products in technical and formulated pyridazinones was rapidly performed by gas-liquid chromatography with complete resolution of all compounds. Quantitative determination by the internal standard technique is accurate and precise. The lower limit of detectability is 8 × 10–12 g/sec with a flame ionization detector and 1 × 10–12 g/sec with a nitrogen-phosphorus selective detector operating in the nitrogen mode.

Collaborative Study of the Gas-Liquid Chromatographic Determination of Sorbitol in Bakery Products

1973 ◽  
Vol 56 (1) ◽  
pp. 66-67
Author(s):  
Harvey K Hundley
Keyword(s):  
Aqueous Solution ◽  
Acetic Anhydride ◽  
Collaborative Study ◽  
Chromatographic Determination ◽  
Bakery Products ◽  
Sugar Alcohols ◽  
Flame Ionization ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A GLC method for the determination of sorbitol has been collaboratively studied. Sugar and sugar alcohols are extracted from the bakery products by methanol and the solvent is evaporated. Acetate derivatives are then formed by addition of acetic anhydride in pyridine, and the derivatives are extracted from an aqueous solution with chloroform and analyzed by flame ionization GLC. Collaborative results show a recovery ranging from 90 to 102% sorbitol from bakery products containing 1.5 to 7% sorbitol. The method has been adopted as official first action.

Gas-Liquid Chromatographic Determination of p-Chloroacetanilide in Acetaminophen

1978 ◽  
Vol 61 (1) ◽  
pp. 68-71
Author(s):  
Dorothy K Wyatt ◽  
Lee T Grady
Keyword(s):  
Liquid Chromatography ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Gas Liquid Chromatography ◽  
Flame Ionization ◽  
Glass Column ◽  
Retention Characteristics ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract Gas-liquid chromatography (GLC) coupled with column chromatography was used to accurately determine as little as 25 ppm p-chloroacetanilide in acetaminophen. p-Chloroacetanilide was eluted from a pH 8 phosphate-buffered diatomite partition column by using purified tetrachloroethylene (acetaminophen was retained). This solution was concentrated, internal standard (docosane) was added, and p-chloroacetanilide was determined by using a 0.9 m × 2 mm glass column packed with 3% Poly A 103 on Supelcoport and a flame ionization detector with electronic integration. Standard curves were linear for 10–100 ppm p-chloroacetanilide. Various chromatographic materials were investigated for optimal retention characteristics. High pressure liquid chromatography (HPLC) was also evaluated as an alternative; however, lack of reproducibility of the HPLC column favored the GLC procedure.

Gas-Liquid Chromatographic Determination of Isosorbide Dinitrate in Tablets

1977 ◽  
Vol 60 (6) ◽  
pp. 1341-1344
Author(s):  
David G Prue ◽  
Raymond N Johnson ◽  
Boen T Kho
Keyword(s):  
Isosorbide Dinitrate ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Raw Material ◽  
Phase System ◽  
Flame Ionization ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A gas-liquid chromatographic (GLC) method is described for determining isosorbide dinitrate (ISDN) in tablets. ISDN is extracted from tablet excipients by a 2-phase system composed of water-ethyl ether, and detected and quantitated with a flame ionization detector after separation from the internal standard (glyceryl tributyrate) on a 3% OV-210 column. Ten replicate assays on 2 different batches of tablets, each containing 5 mg ISDN, gave coefficients of variation of 1.16 and 1.48%, respectively. Comparison of results obtained for tablets containing 5, 10, and 40 mg ISDN, and for diluted isosorbide dinitrate raw material containing 25% ISDN, showed good correlation among the GLC, USP colorimetric, and USP polarographic procedures. Assay of synthetic mixtures containing ISDN, isosorbide-2-mononitrate, and isosorbide-5-mononitrate demonstrated that the GLC procedure is specific for ISDN, whereas the USP polarographic procedure is subject to interference from the mononitrates.

Gas-Liquid Chromatographic Determination of IV-Octylbicycloheptene Dicarboximide

1975 ◽  
Vol 58 (4) ◽  
pp. 845-849
Author(s):  
Vernon J Meinen
Keyword(s):  
Quantitative Determination ◽  
Chromatographic Determination ◽  
Flame Ionization Detector ◽  
Ionization Detector ◽  
Flame Ionization ◽  
Preliminary Work ◽  
Technical Material ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A gas-liquid chromatographic (GLC) method is described for the quantitative determination of /V-octylbicycloheptene dicarboximide (MGK 264 synergist) in technical materials and in various formulations. The samples are diluted with acetone and analyzed by GLC, using a flame ionization detector and a column packed with OV-1 on Chromosorb W (HP). Preliminary work indicates that satisfactory results can be obtained with the technical material and several different formulations.

Gas-Liquid Chromatographic Determination of Sorbitol in Cooked Sausage Products

1978 ◽  
Vol 61 (1) ◽  
pp. 164-166
Author(s):  
Fred A Moseley ◽  
Joel S Salinsky ◽  
Robert W Woods
Keyword(s):  
Chromatographic Determination ◽  
Flame Ionization Detector ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Simple Method ◽  
Flame Ionization ◽  
Freeze Dried ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A rapid and simple method of analysis has been developed for sorbitol in cooked sausage products. Sorbitol is extracted from cooked sausage products with water, an aliquot of the extract is freeze-dried, and the trimethylsilyl (TMS) derivative of sorbitol is formed. An aliquot of the TMS-sorbitol is injected into a gas chromatograph and measured by a flame ionization detector. Analysis of fortified samples shows that the recovery compares well with known amounts of sorbitol added.

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