Synthesis and spectrophotometric studies of CT complex between 1,2-dimethylimidazole and picric acid in different polar solvents: exploring antimicrobial activities and molecular (DNA) docking

2020 ◽  
pp. 1-17
Author(s):  
Ishaat M. Khan ◽  
Sonam Shakya ◽  
Maidul Islam ◽  
Shadab Khan ◽  
Hasina Najnin
Keyword(s):  
Picric Acid ◽  
Antimicrobial Activities ◽  
Polar Solvents ◽  
Ct Complex ◽  
Dna Docking

Protolytic equilibria of picric acid in a mixture of protophobic and protophilic polar solvents non-donors of H-bonds

2011 ◽  
Vol 81 (6) ◽  
pp. 1153-1158 ◽  
Author(s):  
D. O. Ruzanov ◽  
D. V. Samoilov ◽  
K. V. Gensh ◽  
Yu. E. Zevatskii ◽  
N. P. Novoselov
Keyword(s):  
Picric Acid ◽  
Polar Solvents ◽  
Protolytic Equilibria

scholarly journals A Remarkably High-Speed Solution-Phase Combinatorial Synthesis of 2-Substituted-Amino-4-Aryl Thiazoles in Polar Solvents in the Absence of a Catalyst under Ambient Conditions and Study of Their Antimicrobial Activities

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Satish N. Dighe ◽  
Pratip K. Chaskar ◽  
Kishor S. Jain ◽  
Manisha S. Phoujdar ◽  
Kumar V. Srinivasan
Keyword(s):  
High Speed ◽  
Antimicrobial Activities ◽  
Combinatorial Synthesis ◽  
Solution Phase ◽  
Ambient Conditions ◽  
Polar Solvents ◽  
Antibacterial And Antifungal Activities ◽  
Polarity Index ◽  
Bacteria And Fungi

Remarkably high-speed synthesis of 2-substituted amino-4-aryl thiazoles in polar solvents with a minimum threshold polarity index of 4.8 was found to proceed to completion in just 30–40 sec. affording excellent yields of thiazoles under ambient temperature conditions without the use of any additional catalyst. The purification-free procedure afforded libraries based around a known pharmacophore, namely, substituted arylthiazoles and generated samples of high purity. In terms of combinatorial synthesis in a single solution phase, our protocol is significantly better than those hitherto reported and is amenable for HTS. The in vitro biological tests of some thiazoles showed good activity towards gram-positive bacteria, gram-negative bacteria and fungi comparable with the standard drugs, nitrofurantoin and griseofulvin, for their antibacterial and antifungal activities, respectively.

Photochemical reactions of charge-transfer complexes. The irradiation of the charge-transfer complexes between 1,4-, 1,5-, and 2,3-dimethoxynaphthalenes and 1,2-dicyanoethylenes

1980 ◽  
Vol 58 (9) ◽  
pp. 918-927 ◽  
Author(s):  
P. C. Wong ◽  
D. R. Arnold
Keyword(s):  
Charge Transfer ◽  
Triplet State ◽  
Ion Pair ◽  
Photochemical Reactions ◽  
Association Constants ◽  
Charge Transfer Complexes ◽  
Polar Solvents ◽  
Photostationary State ◽  
Ct Complex ◽  
Ct Complexes

The first part of this paper describes the experimental search for a donor which would complex preferentially one of the isomers of 1,2-dicyanoethylene. This involved measuring the association constants (KcDA) of the charge-transfer (ct) complexes of several dimethoxynaphthalenes (DMN) with maleonitrile (MN) and fumaronitrile (FN). From the measured KcDA, we found that MN complexes more strongly than FN with 1,4- and 1,5-DMN but that FN complexes more strongly with 2,3-DMN than does MN. These results are explained in terms of more than one favourable geometry for the ct complexes, since the donors are relatively large compared to the acceptors.Irradiation of the ct complexes between 1,4-, 1,5-, or 2,3-DMN and 1,2-dicyanoethylene led to isomerization of the olefins. The photostationary state depends on the absorption spectra of the ct complexes formed between the donor and the isomeric olefins. From spectroscopic and photo-CIDNP studies, we find evidence that the isomerization in polar solvents takes place via the triplet state of the olefin. The triplet is formed from the radical ion pair resulting after excitation of the ct complex.

The Ultrastructure of Myocardial Cells in Normal and Cardiac Lethal Mutant Mexican Axolotls, (Ambystoma Mexicanum)

1970 ◽  
Vol 28 ◽  
pp. 62-63
Author(s):  
Larry F. Lemanski ◽  
Eldridge M. Bertke ◽  
J. T. Justus
Keyword(s):  
Fine Structure ◽  
Heart Development ◽  
Osmium Tetroxide ◽  
Picric Acid ◽  
Ambystoma Mexicanum ◽  
Recessive Mutation ◽  
Acid Mixture ◽  
Myocardial Cells ◽  
Lethal Mutant ◽  
Mexican Axolotl

A recessive mutation has been recently described in the Mexican Axolotl, Ambystoma mexicanum; in which the heart forms structurally, but does not contract (Humphrey, 1968. Anat. Rec. 160:475). In this study, the fine structure of myocardial cells from normal (+/+; +/c) and cardiac lethal mutant (c/c) embryos at Harrison's stage 40 was compared. The hearts were fixed in a 0.1 M phosphate buffered formaldehyde-glutaraldehyde-picric acid-styphnic acid mixture and were post fixed in 0.1 M s-collidine buffered 1% osmium tetroxide. A detailed study of heart development in normal and mutant embryos from stages 25-46 will be described elsewhere.

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