Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases

2016 ◽  
Vol 51 (10) ◽  
pp. 1233-1238 ◽  
Author(s):  
Lidewij Spelt ◽  
Agata Sasor ◽  
Daniel Ansari ◽  
Roland Andersson
Keyword(s):  
Colon Cancer ◽  
Liver Metastases ◽  
Tumour Growth ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Primary Colon Cancer ◽  
Primary Colon

scholarly journals Adjuvant Therapy for Colon Cancer in the New Millenium

2003 ◽  
Vol 92 (1) ◽  
pp. 57-64 ◽  
Author(s):  
S. Rao ◽  
D. Cunningham
Keyword(s):  
Colon Cancer ◽  
Adjuvant Therapy ◽  
Advanced Colorectal Cancer ◽  
Significant Proportion ◽  
Adjuvant Setting ◽  
Conventional Chemotherapy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Stage Iii Colon Cancer

A significant proportion of patients with colon cancer who undergo curative surgical resection develop metastatic disease. Over the last 20 years large prospective randomised studies have demonstrated a clear survival benefit for patients with stage III colon cancer who are treated with adjuvant 5FU based chemotherapy. At the present time 6 months of 5FU and leucovorin is generally considered the standard adjuvant therapy. For stage II disease the routine use of adjuvant treatment remains controversial. Newer drugs such as oxaliplatin, irinotecan, and the oral fluoropyrimidines have proven active in advanced colorectal cancer and are currently being evaluated in the adjuvant setting. Molecular markers for this disease are being identified and may help define those patients who would benefit from therapy. The integration of adjuvant immunotherapy with conventional chemotherapy offers the potential to improve the long-term outcome for surgically resected colon cancer.

Long-Term Outcome After Conventional Two-Stage Hepatectomy Versus Tourniquet-ALPPS in Colorectal Liver Metastases: A Propensity Score Matching Analysis

2019 ◽  
Vol 43 (9) ◽  
pp. 2281-2289 ◽  
Author(s):  
Ricardo Robles-Campos ◽  
Roberto Brusadin ◽  
Asunción López-Conesa ◽  
Víctor López-López ◽  
Álvaro Navarro-Barrios ◽  
...  
Keyword(s):  
Propensity Score ◽  
Liver Metastases ◽  
Propensity Score Matching ◽  
Colorectal Liver Metastases ◽  
Two Stage ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Propensity Score Matching Analysis

Long-term outcome after R1 resection for colorectal liver metastases: Is a cure possible?

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 3579-3579
Author(s):  
Isamu Hosokawa ◽  
Oriana Ciacio ◽  
Gabriella Pittau ◽  
Maximiliano Gelli ◽  
Marc Antoine Allard ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Term Outcome ◽  
Long Term Outcome ◽  
R1 Resection

scholarly journals Repeated Liver Resection for Colorectal Liver Metastases: A Comparison with Primary Liver Resections concerning Perioperative and Long-Term Outcome

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Kristoffer Jönsson ◽  
Gerd Gröndahl ◽  
Martin Salö ◽  
Bobby Tingstedt ◽  
Roland Andersson
Keyword(s):  
Liver Resection ◽  
Blood Loss ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Postoperative Mortality ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Liver Resections

Introduction. 60% of patients operated for colorectal liver metastases (CRLM) will develop recurrent disease and some may be candidates for a repeated liver resection. The study aimed to evaluate differences in intraoperative blood loss and complications comparing the primary and the repeated liver resection for metastases of colorectal cancer (CRC), as well as to evaluate differences in long-time follow-up.Method. 32 patients underwent 34 repeated liver resections due to recurrence of CRLM an studied retrospectively to identify potential differences between the primary and the repeat resections.Results. There was no 30-day postoperative mortality or postoperative hospital deaths. The median blood loss at repeat resection (1850 mL) was significantly (P=0.014) higher as compared to the primary liver resection (1000 mL). This did not have any effect on the rate of complications, even though increased bleeding in itself was a risk factor for complications. There were no differences in survival at long-term follow-up.Discussion. A repeated liver resection for CRLM was associated with an increased intraoperative bleeding as compared to the first resection. Possible explanations include presence of adhesions, deranged vascular anatomy, more complicated operations and the effects on the liver by chemotherapy following the first liver resection. 30 out of 32 patients had only one reresection of the liver.

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