(S046) Long-Term Outcome and Toxicity of Stereotactic Ablative Body Radiotherapy (SABR) for Liver Metastases From Solid Tumors

Introduction. 60% of patients operated for colorectal liver metastases (CRLM) will develop recurrent disease and some may be candidates for a repeated liver resection. The study aimed to evaluate differences in intraoperative blood loss and complications comparing the primary and the repeated liver resection for metastases of colorectal cancer (CRC), as well as to evaluate differences in long-time follow-up.Method. 32 patients underwent 34 repeated liver resections due to recurrence of CRLM an studied retrospectively to identify potential differences between the primary and the repeat resections.Results. There was no 30-day postoperative mortality or postoperative hospital deaths. The median blood loss at repeat resection (1850 mL) was significantly (P=0.014) higher as compared to the primary liver resection (1000 mL). This did not have any effect on the rate of complications, even though increased bleeding in itself was a risk factor for complications. There were no differences in survival at long-term follow-up.Discussion. A repeated liver resection for CRLM was associated with an increased intraoperative bleeding as compared to the first resection. Possible explanations include presence of adhesions, deranged vascular anatomy, more complicated operations and the effects on the liver by chemotherapy following the first liver resection. 30 out of 32 patients had only one reresection of the liver.

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Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases

Scandinavian Journal of Gastroenterology ◽

10.1080/00365521.2016.1190400 ◽

2016 ◽

Vol 51 (10) ◽

pp. 1233-1238 ◽

Cited By ~ 3

Author(s):

Lidewij Spelt ◽

Agata Sasor ◽

Daniel Ansari ◽

Roland Andersson

Keyword(s):

Colon Cancer ◽

Liver Metastases ◽

Tumour Growth ◽

Term Outcome ◽

Long Term Outcome ◽

Primary Colon Cancer ◽

Primary Colon

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Surgical Strategy Based on Indocyanine Green Test for Chemotherapy-Associated Liver Injury and Long-Term Outcome in Colorectal Liver Metastases

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-018-3712-2 ◽

2018 ◽

Vol 22 (6) ◽

pp. 1077-1088 ◽

Cited By ~ 3

Author(s):

Takeshi Takamoto ◽

Takuya Hashimoto ◽

Akihiko Ichida ◽

Kei Shimada ◽

Yoshikazu Maruyama ◽

...

Keyword(s):

Liver Injury ◽

Indocyanine Green ◽

Liver Metastases ◽

Colorectal Liver Metastases ◽

Surgical Strategy ◽

Term Outcome ◽

Long Term Outcome ◽

Indocyanine Green Test

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Meta-analysis of gender effect for first-line chronomodulated 5-fluorouracil-leucovorin-oxaliplatin (ChronoFLO) compared with FOLFOX or constant infusion (conventional delivery, CONV) against metastatic colorectal cancer (MCC) in three international controlled phase III randomized trials (RT)

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.4112 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 4112-4112 ◽

Cited By ~ 1

Author(s):

F. Levi ◽

P. Innominato ◽

A. Poncet ◽

T. Moreau ◽

S. Iacobelli ◽

...

Keyword(s):

Liver Metastases ◽

Meta Analysis ◽

Progression Free Survival ◽

Phase Iii ◽

Constant Infusion ◽

Term Outcome ◽

Long Term Outcome ◽

Significant Difference

4112 Background: Gender predicted for the most effective schedule in a RT of ChronoFLO vs CONV against MCC: overall survival (OS) was significantly increased in men on chronoFLO vs FOLFOX, whereas the reverse was found in women (Giacchetti, JCO 2006). Methods: To assess the relevance of gender for patient (pt) outcome, meta-analysis was performed on individual pt data (IPD) from 3 RT in 845 MCC pts treated with chronoFLO vs CONV (346 F, 499 M at 36 centers in 1990–2002)(Lévi, JNCI 1994; Lancet 1997). Data bases were merged and updated at 9 y after inclusion of the 1st pt. Main prognostic factors were comparable in each RT according to gender and treatment arm (median age: 61y; PS=0, 46% pts; liver M, 85% pts; liver involvement >25%, 41% pts; lung M, 37% pts; CEA>10, 56% pts). Results: No significant difference was found according to delivery schedule or gender in the whole population for Response Rate (RR), Progression-Free Survival (PFS) and OS. However, men on chronoFLO had highest RR, longest PFS and OS. PFS and OS were highest in women on CONV ( Table ). The rate of complete macroscopic resections of liver metastases (R0+R1) was 12.5% in men on chronoFLO vs 7.8–8.5% in men on CONV or in women on either schedule. A complete histologic response of liver metastases was documented in 2.1% of the men on chronoFLO vs 0–1.1% in the other groups. The relative risk of an earlier death in men vs women was 0.76 [95% CL, 0.91 to 0.94] on chronoFLO and 1.24 [0.99 to 1.56] on CONV. Conclusions: This IPD meta-analysis of 3 RT in MCC with a minimum follow up of 5 years confirms that men benefit from chronoFLO as compared to CONV delivery, with regard to long term outcome and medico-surgical strategy. ChronoFLO should be preferred to conventional oxaliplatin-5-FU-LV schedules in men with MCC. Support: ARTBC Internationale, P. Brousse Hospital, Villejuif, France. [Table: see text] No significant financial relationships to disclose.

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Early and Long-Term Outcomes of Patients Undergoing Liver Resection and Diaphragm Excision for Advanced Colorectal Liver Metastases

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2009.91.6.483 ◽

2009 ◽

Vol 91 (6) ◽

pp. 483-488 ◽

Cited By ~ 7

Author(s):

Jeffrey T Lordan ◽

Angela Riga ◽

Tim R Worthington ◽

Nariman D Karanjia

Keyword(s):

Liver Resection ◽

Liver Metastases ◽

Colorectal Liver Metastases ◽

Tumour Size ◽

Disease Free Survival ◽

Long Term Outcomes ◽

Term Outcome ◽

Long Term Outcome ◽

Liver Resections

INTRODUCTION At present, liver resection offers the best long-term outcome and only chance for cure in patients with colorectal liver metastases. However, there are no large series that report the early and long-term outcomes of patients who require simultaneous diaphragm excision. This study was designed to investigate these patients. PATIENTS AND METHODS A total of 285 consecutive liver resections were performed over a 10-year period. Of these, 258 had liver resections alone and 27 underwent liver resection and simultaneous diaphragm excision. Data were collected prospectively and analysed retrospectively. Pre-operative assessment was standardised. The outcomes between the two groups were compared. RESULT There was no difference in age, hospital stay or intra-operative blood loss. The diaphragm was histologically involved in four out of 27 resections. As a result, the cancer involved resection margin incidence was greater in the liver resection and diaphragm excision group (14.8% versus 3.9%; P = 0.12). The median tumour size was also different between the two groups (60 mm versus 30 mm; P = 0.001). The liver and diaphragm resection group had a greater peri-operative complication rate (44.4% versus 21.3%; P = 0.02) and mortality (7.4% versus 1.6%; P = 0.25). Overall and disease-free survival was significantly worse in the group who underwent simultaneous diaphragm excision and liver resection (P = 0.04 and P = 0.005, respectively). Diaphragm invasion was found to be an independent predictor of poor overall outcome (P = 0.02). CONCLUSION Liver resection and simultaneous diaphragm excision have a greater incidence of peri-operative morbidity and mortality and a significantly worse long-term outcome compared with liver resection alone. However, these data suggest that liver resection in the presence of diaphragm invasion may still offer a favourable outcome compared with chemotherapy treatment alone. Therefore, we believe that diaphragm involvement by tumour should not be a contra-indication to hepatectomy.

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