Pain Produced by Electric Stimulation of the Rectum in Patients with Irritable Bowel Syndrome: Further Evidence of Visceral Hyperalgesia

1999 ◽  
Vol 34 (10) ◽  
pp. 1001-1006 ◽  
Author(s):  
P. Rössel, A. M. Drewes, P. Peterse
Keyword(s):  
Irritable Bowel Syndrome ◽  
Electric Stimulation ◽  
Visceral Hyperalgesia ◽  
Irritable Bowel ◽  
Stimulation Of

scholarly journals Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function

1999 ◽  
Vol 13 (suppl a) ◽  
pp. 12A-14A ◽  
Author(s):  
Fernando Azpiroz
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Symptoms ◽  
Afferent Input ◽  
Sensory Function ◽  
Visceral Hyperalgesia ◽  
Gut Dysfunction ◽  
Irritable Bowel ◽  
Clinical Conditions ◽  
Normal Perception ◽  
Stimulation Of

Growing evidence suggests that symptoms in patients with irritable bowel syndrome (IBS) may be due to a visceral sensory dysfunction. Specifically, it has been shown that patients with IBS have hypersensitive responses to distension of the rectum, whereas their tolerance to somatic stimuli is normal or even increased. Furthermore, patients with IBS have hypersensitivity of the small bowel, which selectively affects mechanosensitive afferents, with normal perception of electrical stimulation of the gut. Sensory dysfunctions may also be associated with altered reflex activity, which may contribute to the clinical symptoms. Normally, a series of mechanisms at different strata of the nervous system modulate visceral afferent input and determine conscious perception. Conceivably, a dysfunction of these regulatory mechanisms may alter sensitivity in clinical conditions. To date, neither the origin nor the clinical significance of visceral hyperalgesia has been elucidated. However, it seems likely that the sensory and reflex dysfunctions of the gut in IBS may combine to different degrees, and their interaction may explain the clinical pleomorphism of the syndrome.

scholarly journals Study on the Mechanism Underlying the Regulation of the NMDA Receptor Pathway in Spinal Dorsal Horns of Visceral Hypersensitivity Rats by Moxibustion

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
L. D. Wang ◽  
J. M. Zhao ◽  
R. J. Huang ◽  
L. Y. Tan ◽  
Z. H. Hu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Irritable Bowel Syndrome ◽  
Visceral Pain ◽  
Intrathecal Injection ◽  
Visceral Hypersensitivity ◽  
Regulatory Function ◽  
Visceral Hyperalgesia ◽  
Spinal Dorsal ◽  
Dorsal Horns ◽  
Irritable Bowel

Visceral hypersensitivity is enhanced in irritable bowel syndrome (IBS) patients. Treatment of IBS visceral pain by moxibustion methods has a long history and rich clinical experience. In the clinic, moxibustion on the Tianshu (ST25) and Shangjuxu (ST37) acupoints can effectively treat bowel disease with visceral pain and diarrhea symptoms. To investigate the regulatory function of moxibustion on the Tianshu (ST25) and Shangjuxu (ST37) acupoints on spinal cord NR1, NR2B, and PKCεprotein and mRNA expression in irritable bowel syndrome (IBS) visceral hypersensitivity rats, we did some research. In the study, we found that moxibustion effectively relieved the IBS visceral hyperalgesia status of rats. Analgesic effect of moxibustion was similar to intrathecal injection of Ro 25-6981. The expression of NR1, NR2B, and PKCεin the spinal dorsal horns of IBS visceral hyperalgesia rats increased. Moxibustion on the Tianshu and Shangjuxu acupoints might inhibit the visceral hypersensitivity, simultaneously decreasing the expression of NR1, NR2B, and PKCεin spinal cord of IBS visceral hyperalgesia rats. Based on the above experimental results, we hypothesized NR1, NR2B, and PKCεof spinal cord could play an important role in moxibustion inhibiting the process of central sensitization and visceral hyperalgesia state.

scholarly journals Effect of Electroacupuncture on Visceral Hyperalgesia, Serotonin and Fos Expression in an Animal Model of Irritable Bowel Syndrome

2010 ◽  
Vol 16 (3) ◽  
pp. 306-314 ◽  
Author(s):  
Justin CY Wu ◽  
Eric TC Ziea ◽  
Lixing Lao ◽  
Emma FC Lam ◽  
Catherine SM Chan ◽  
...  
Keyword(s):  
Animal Model ◽  
Irritable Bowel Syndrome ◽  
Visceral Hyperalgesia ◽  
Fos Expression ◽  
Irritable Bowel

scholarly journals Shaoyao-Gancao Decoction Relieves Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome via Inactivating Transient Receptor Potential Vanilloid Type 1 and Reducing Serotonin Synthesis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yun-Yun Shao ◽  
Yi-Ting Guo ◽  
Jian-ping Gao ◽  
Jun-Jin Liu ◽  
Zhuang-Peng Chang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Cell Count ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Low Grade ◽  
Visceral Hyperalgesia ◽  
Transient Receptor ◽  
Irritable Bowel ◽  
In Cells

Postinflammatory irritable bowel syndrome (PI-IBS) is a common functional gastrointestinal disorder, which is characterized by abdominal pain, low-grade inflammation, and visceral hypersensitivity. Shaoyao-Gancao decoction (SGD) has been used to improve the clinical symptoms of abdominal spasmodic pain accompanying acute gastroenteritis, but the underlying therapeutic mechanism has not been fully elucidated. In the present study, a rat model of PI-IBS was established via rectal administration of TNBS. Rats were scored daily for 28 days using disease activity index (DAI). Abdominal withdrawal reflex (AWR) was used to measure the pain threshold. After SGD (6.25, 12.5, and 25 g/kg/d) treatment for 14 days, rat colonic tissue was collected for histopathological grading, enterochromaffin (EC) cell count, and 5-HT content measurement. RT-qPCR and western blot analyses were employed to detect the gene and protein level of tryptophan hydroxylase (TPH), serotonin reuptake transporter (SERT), and transient receptor potential vanilloid 1 (TRPV1). To further validate the effect of SGD on TRPV1, another experiment was performed in cells. The results revealed that visceral hyperalgesia, reflected by increased DAI, AWR, pathological injury score, 5-HT content, and EC cell count in PI-IBS rats, was significantly ameliorated by SGD. In cells, SGD markedly inhibited the expression and function of TRPV1. Moreover, the expression levels of TPH were also repressed by SGD. The findings of the present study indicated that the therapeutic effect of SGD on visceral hyperalgesia may be closely associated with the regulatory role of TRPV1 and 5-HT signaling pathways.

S1817 Visceral Hyperalgesia Is Associated with Somatic Hyperalgesia and Deficits in Pain Modulation in Patients with Irritable Bowel Syndrome (IBS)

2008 ◽  
Vol 134 (4) ◽  
pp. A-276
Author(s):  
Piché Mathieu ◽  
Marianne Arsenault ◽  
Pierre Poitras ◽  
Pierre Rainville ◽  
Mickael Bouin
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Modulation ◽  
Visceral Hyperalgesia ◽  
Irritable Bowel
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