Microwave accelerated the solvent-free synthesis of 4-aryl-3,4-dihydrocoumarin via the tandem reaction of cinnamic acids with phenols catalyzed by Amberlyst 15 resin

2021 ◽  
pp. 1-17
Author(s):  
Huu-Phuoc Le ◽  
Cong-Thang Duong ◽  
Xuan-Triet Nguyen ◽  
Thi Xuan Thi Luu
Keyword(s):  
Solvent Free ◽  
Tandem Reaction ◽  
Cinnamic Acids ◽  
Amberlyst 15 ◽  
Solvent Free Synthesis

scholarly journals Metal-free and solvent-free synthesis of m-terphenyls through tandem cyclocondensation of aryl methyl ketones with triethyl orthoformate

RSC Advances ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 12113-12118 ◽  
Author(s):  
Xiaoqin Xiao ◽  
Juan Luo ◽  
Zongjie Gan ◽  
Wengao Jiang ◽  
Qiang Tang
Keyword(s):  
Solvent Free ◽  
Triethyl Orthoformate ◽  
Tandem Reaction ◽  
Methyl Ketones ◽  
One Pot ◽  
Metal Free ◽  
Solvent Free Synthesis ◽  
Aryl Methyl

A facile metal-free and solvent-free benzannulation was developed for the construction of m-terphenyl derivatives starting from aryl methyl ketones and triethyl orthoformate. This is a tandem reaction which merged six steps into one-pot procedure.

Solvent-Free Synthesis of α-Amino Ketones from α-Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement

Synlett ◽  
2019 ◽  
Vol 30 (06) ◽  
pp. 694-698
Author(s):  
Qing-le Zeng ◽  
Guang-xun Li ◽  
Zhuo Tang ◽  
Ling-yu Li
Keyword(s):  
Efficient Method ◽  
Solvent Free ◽  
Secondary Amines ◽  
Tandem Reaction ◽  
Reaction Sequence ◽  
Hydroxy Ketones ◽  
Solvent Free Synthesis ◽  
Moderate Yield

Heyns rearrangement have been famous for carbohydrate chemists for several decades. However, this reaction was underrated as a useful method for synthetic chemists due to preparative shortcomings. Herein we developed an efficient method for the synthesis of pharmaceutically important α-amino ketones from readily available α-hydroxy ketones and secondary amines through a tandem reaction sequence based on Heyns rearrangement. The reaction smoothly proceeded by using catalytic PTSA as catalyst without solvent. Primary and secondary α-hydroxy ketones were readily used and regioselectively afforded the correspondingly α-amino ketones with moderate yield.

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