Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment

Xenobiotica ◽

10.1080/00498254.2019.1709133 ◽

2020 ◽

Vol 50 (9) ◽

pp. 1023-1031 ◽

Author(s):

Shin-ichiro Ogawa ◽

Makiko Shimizu ◽

Hiroshi Yamazaki

Keyword(s):

Hepatic Impairment ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2013.01.008 ◽

2013 ◽

Vol 65 (3) ◽

pp. 316-324 ◽

Author(s):

Ai Tsukada ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Ryohji Takano ◽

Makiko Shimizu ◽

...

Keyword(s):

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Melengestrol Acetate ◽

Physiologically Based

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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2016.1147102 ◽

2016 ◽

Vol 46 (12) ◽

pp. 1049-1055 ◽

Author(s):

Masahiro Utoh ◽

Hiroshi Suemizu ◽

Marina Mitsui ◽

Mirai Kawano ◽

Akiko Toda ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Human Hepatocytes ◽

Physiologically Based Pharmacokinetic Modeling ◽

Common Marmosets ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Using Physiologically Based Pharmacokinetic Modeling for Predicting the Effects of Hepatic Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given as a Combination Tablet

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12675 ◽

2021 ◽

Author(s):

Lei Sun ◽

Zoe Barter ◽

Lisa von Moltke ◽

Karen Rowland Yeo

Keyword(s):

Hepatic Impairment ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Combination Tablet ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1118650 ◽

2015 ◽

Vol 46 (9) ◽

pp. 759-764 ◽

Author(s):

Satomi Shida ◽

Hiroshi Yamazaki

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Applications of Physiologically Based Pharmacokinetic Modeling of Rivaroxaban—Renal and Hepatic Impairment and Drug‐Drug Interaction Potential

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1784 ◽

2021 ◽

Author(s):

Stefan Willmann ◽

Katrin Coboeken ◽

Stefanie Kapsa ◽

Kirstin Thelen ◽

Markus Mundhenke ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Hepatic Impairment ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2125 ◽

2020 ◽

Author(s):

Tycho Heimbach ◽

Yuan Chen ◽

Jun Chen ◽

Vaishali Dixit ◽

Neil Parrott ◽

...

Keyword(s):

Pharmaceutical Industry ◽

Hepatic Impairment ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1028511 ◽

2015 ◽

Vol 45 (10) ◽

pp. 881-886 ◽

Author(s):

Satomi Shida ◽

Masahiro Utoh ◽

Norie Murayama ◽

Makiko Shimizu ◽

Yasuhiro Uno ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human Plasma Concentrations of Tolbutamide and Acetaminophen Extrapolated from in vivo Animal Pharmacokinetics Using in vitro Human Hepatic Clearances and Simple Physiologically Based Pharmacokinetic Modeling for Radio-labeled Microdose Clinical Studies

RADIOISOTOPES ◽

10.3769/radioisotopes.64.509 ◽

2015 ◽

Vol 64 (8) ◽

pp. 509-519 ◽

Author(s):

Hiroshi YAMAZAKI ◽

Eriko KUNIKANE ◽

Sayako NISHIYAMA ◽

Norie MURAYAMA ◽

Makiko SHIMIZU ◽

...

Keyword(s):

Human Plasma ◽

Clinical Studies ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Animal Pharmacokinetics

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Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2014.06.028 ◽

2014 ◽

Vol 70 (1) ◽

pp. 214-221 ◽

Author(s):

Masanao Yamashita ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Sayako Nishiyama ◽

Makiko Shimizu ◽

...

Keyword(s):

Human Plasma ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Application of physiologically‐based pharmacokinetic modeling in hepatic impairment populations (1064.9)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.1064.9 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Jennifer Sager ◽

Matt Hsu ◽

Nina Isoherranen ◽

Larry Wienkers ◽

Jan Wahlstrom ◽

...

Keyword(s):

Hepatic Impairment ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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