Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition

Xenobiotica ◽  
2021 ◽  
pp. 1-56
Author(s):  
John P. Kowalski ◽  
Robert D. Pelletier ◽  
Matthew G. McDonald ◽  
Edward J. Kelly ◽  
Allan E. Rettie
Keyword(s):  
Cytochrome P450 ◽  
Octanoic Acid ◽  
Selective Inhibitor ◽  
Human Cytochrome ◽  
Target Effects

scholarly journals A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2

2015 ◽  
Vol 58 (16) ◽  
pp. 6481-6493 ◽  
Author(s):  
Jiawang Liu ◽  
Peter T. Pham ◽  
Elena V. Skripnikova ◽  
Shilong Zheng ◽  
La’nese J. Lovings ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Design ◽  
Selective Inhibitor ◽  
Cytochrome P450 1A2 ◽  
Human Cytochrome

scholarly journals Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

2020 ◽  
Vol 63 (3) ◽  
pp. 1415-1433 ◽  
Author(s):  
William C. Wright ◽  
Jude Chenge ◽  
Jingheng Wang ◽  
Hazel M. Girvan ◽  
Lei Yang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Selective Inhibitor ◽  
Clobetasol Propionate ◽  
Human Cytochrome ◽  
Cytochrome P450 3A5

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052457079-8
Author(s):  
Y. Nishiya ◽  
K. Hagihara ◽  
A. Kurihara ◽  
N. Okudaira ◽  
N.A. Farid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19

scholarly journals CO Binding Kinetics of Human Cytochrome P450 3A4

1995 ◽  
Vol 270 (10) ◽  
pp. 5014-5018 ◽  
Author(s):  
Aditya P. Koley ◽  
Jeroen T. M. Buters ◽  
Richard C. Robinson ◽  
Allen Markowitz ◽  
Fred K. Friedman
Keyword(s):  
Cytochrome P450 ◽  
Binding Kinetics ◽  
Cytochrome P450 3A4 ◽  
Human Cytochrome ◽  
Kinetics Of

In vitro inhibitory mechanisms and molecular docking of 1′-S-1′-acetoxychavicol acetate on human cytochrome P450 enzymes

Phytomedicine ◽  
2017 ◽  
Vol 31 ◽  
pp. 1-9 ◽  
Author(s):  
A.K.M. Mahmudul Haque ◽  
Kok Hoong Leong ◽  
Yoke Lin Lo ◽  
Khalijah Awang ◽  
Noor Hasima Nagoor
Keyword(s):  
Cytochrome P450 ◽  
Molecular Docking ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Mechanisms ◽  
Human Cytochrome
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