Preparation and Characterization of Poly (Hydroxy Ethyl Methyl Acrylate-Co-Acrylic Acid) Microspheres for Drug Delivery Application

2013 ◽  
Vol 62 (13) ◽  
pp. 700-705 ◽  
Author(s):  
B. Yerri Swamy ◽  
C. Venkata Prasad ◽  
K. Chowdoji Rao ◽  
M. C. S. Subha
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olalekan A. Balogun-Agbaje ◽  
Olubusola A. Odeniyi ◽  
Michael A. Odeniyi

Abstract Background Poly-γ-glutamic acid (γ-PGA) is a biopolymer of microbial origin, consisting of repeating units of l-glutamic acid and/or D-glutamic acid. The biopolymer has found use in the fields of agriculture, food, wastewater, and medicine, owing to its non-toxic, biodegradable, and biocompatible properties. Due to its biodegradability, γ-PGA is being tipped to dislodge synthetic plastics in drug delivery application. High cost of production, relative to plastics, is however a clog in the wheel of achieving this. Main body of abstract This review looked at the production, nanoparticles fabrication, and drug delivery application of γ-PGA. γ-PGA production optimization by modifying the fermentation medium to tailor towards the production of desirable polymer at reduced cost and techniques for the formulation of γ-PGA nanoparticle as well as its characterization were discussed. This review also evaluated the application of γ-PGA and its nanoparticles in the delivery of drugs to action site. Characterization of γ-PGA and its nanoparticles is a crucial step towards determining the applicability of the biopolymer. γ-PGA has been used in the delivery of active agents to action sites. Conclusion This review highlights some of the efforts that have been made in the appraisal of γ-PGA and its nanoparticles for drug delivery. γ-PGA is a candidate for future extensive use in drug delivery.


2012 ◽  
Vol 15 (1) ◽  
Author(s):  
Christiane Müller ◽  
Katharina Leithner ◽  
Sabine Hauptstein ◽  
Fabian Hintzen ◽  
Willi Salvenmoser ◽  
...  

2014 ◽  
Vol 26 (7) ◽  
pp. 1898-1904 ◽  
Author(s):  
Muhammad Aslam Malana ◽  
Gulistan Firdous ◽  
Abeera Javed ◽  
Zafar Iqbal Zafar ◽  
Muhammad Saleem Khan

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