Impact of maternal anaemia on birth outcomes of teen twin pregnancies: a comparative analysis with mature young mothers

2004 ◽  
Vol 24 (1) ◽  
pp. 16-21 ◽  
Author(s):  
M Nicole Shumpert ◽  
HM Salihu ◽  
RS Kirby
Keyword(s):  
Comparative Analysis ◽  
Birth Outcomes ◽  
Young Mothers ◽  
Maternal Anaemia ◽  
Twin Pregnancies

scholarly journals Effect of older maternal age on birth outcomes in twin pregnancies: a population-based study

2010 ◽  
Vol 31 (2) ◽  
pp. 85-91 ◽  
Author(s):  
S Lisonkova ◽  
S B Sheps ◽  
P A Janssen ◽  
S K Lee ◽  
L Dahlgren
Keyword(s):  
Birth Outcomes ◽  
Maternal Age ◽  
Population Based ◽  
Population Based Study ◽  
Twin Pregnancies

scholarly journals P599 Trimester exposure and pregnancy outcomes in women exposed to golimumab: Results from the company pharmacovigilance database

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S500-S501
Author(s):  
S Esslinger ◽  
M Otero-Lobato ◽  
S Gabriel ◽  
M Clark ◽  
P Sheridan ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Birth Outcomes ◽  
Pregnancy Outcomes ◽  
Spontaneous Abortions ◽  
Live Births ◽  
Elective Abortion ◽  
Induced Abortions ◽  
Pharmacovigilance Database ◽  
Inflammatory Bowel ◽  
Twin Pregnancies

Abstract Background Rheumatologic disorders and inflammatory bowel disease can affect women of childbearing potential. Golimumab (GLM) is approved for several rheumatological indications and ulcerative colitis (UC). To characterise pregnancy outcomes in patients treated with GLM, data obtained from maternal exposure to GLM are presented. Methods These dataset includes individual patient cases reported to the manufacturer through 06 April 2019. Cases included in the analysis were medically confirmed cases of maternal exposures to GLM during pregnancy or within 3 months prior to conception, and a reported pregnancy outcome. Both prospectively reported (ie, pregnancy outcome not known when first reported) and retrospectively reported cases (ie, pregnancy outcome known when first reported) were included. Cases originated from various sources, including spontaneous reporting, clinical studies, and registries. Results Two hundred eight pregnancy cases (131 rheumatological; 43 UC; and 34 other) with 211 reported birth outcomes were identified. Three cases reported twin pregnancies. Of the 208 pregnancy cases, 119 were prospective and 89 were retrospective (Table 1). Average maternal age was 31.9 years. Of the 119 prospectively reported pregnancy cases, 89 (74.8%) resulted in live births, 19 (16.0%) resulted in spontaneous abortion (of these, 42.1% (8/19) received GLM in combination with methotrexate [MTX]), 10 (8.4%) resulted in induced/elective abortion, and 1 (0.8%) resulted in ectopic pregnancy. Overall, 9 congenital anomalies were reported (2 prospective/7 retrospective cases). For 183 of the 208 pregnancy cases with-reported outcomes, the trimester of exposure to GLM was known (Table 2). Among the 110 prospectively reported cases, 82 (74.5%) were exposed during trimester 0 or 1. Of these, 19 had concomitant exposure to MTX, with the following birth outcomes: 8 live births, 8 spontaneous abortions, 3 elective/induced abortions. Eighteen of the prospectively reported cases (16.4%) were exposed to GLM throughout pregnancy (first, second and third trimester) and all resulted in live births. Conclusion The rates of congenital malformations and spontaneous abortions were consistent with published background rates for the general population. Persistent exposure throughout pregnancy was rare, but not associated with apparent clinical sequelae. Limitations of this analysis include the lack of a direct comparison group, the variable amount of data available in the reports, and the possible bias towards reporting more negative outcomes in retrospective cases.

scholarly journals A comparative analysis of selected parameters of vascular angiogenesis in placentas from dizygotic twin pregnancies

2013 ◽  
Vol 84 (11) ◽  
Author(s):  
Katarzyna Orłowska ◽  
Urszula Kowalska-Koprek ◽  
Agata Karowicz-Bilińska
Keyword(s):  
Comparative Analysis ◽  
Dizygotic Twin ◽  
Twin Pregnancies

scholarly journals Prevalence and Outcomes of Twin Pregnancies in Botswana: a National Birth Outcomes Surveillance Study

2020 ◽  
Author(s):  
Arielle Isaacson ◽  
Modiegi Diseko ◽  
Gloria Mayondi ◽  
Judith Mabuta ◽  
Sonya Davey ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Preterm Delivery ◽  
Birth Outcomes ◽  
Low Birthweight ◽  
Child Survival ◽  
Adverse Birth Outcomes ◽  
Adjusted Risk ◽  
High Resource ◽  
Tertiary Center ◽  
Twin Pregnancies

Abstract Background: Twin deliveries have a high risk of adverse birth outcomes, but most data comes from high-resource settings. The prevalence and outcomes of twin pregnancies in Botswana have not previously been reported. Methods: The Tsepamo Study conducted birth outcomes surveillance at 8 hospitals (~40% of all births in Botswana) from August 2014-June 2018 and up to 18 hospitals (~70% of all births in Botswana) from July 2018-March 2019. Maternal demographics, antenatal care visits, ultrasound reports, and infant delivery characteristics (including the number of infants delivered, gestational age (GA) at delivery, birthweight, and vital status at birth and discharge) were abstracted from maternity obstetric records. Log binomial regression models were fit to determine the relative risk (RR), adjusted risk (aRR), and 95% confidence intervals (95% CI) of adverse birth outcomes among twin compared with singleton pregnancies. Higher order multiples were excluded from analyses. Results: Between August 2014 and March 2019, 119,477 deliveries were recorded, including 1859 (1.6%) sets of twins. Women with twin pregnancies had a similar median number of antenatal care visits (9 vs. 10), but were more likely to deliver in a tertiary center (54.8% vs. 45.1%, p<0.001) and more likely to have a C-section (54.6% vs. 22.0%, p<0.001) than women with singletons. Adverse birth outcomes were notably higher in twins than in singletons. Compared with singletons, twin pregnancies had a higher risk of preterm delivery (<37 weeks GA) (47.6% vs. 16.7%, aRR 2.8, 95% CI 2.7, 2.9) and very preterm delivery (<32 weeks) (11.8% vs. 4.0%, aRR 3.0 95% CI 2.6, 3.4). Twin pregnancies were more likely than singletons to have at least one low-birthweight (77.1% vs. 13.6%, aRR 4.5, 95% CI 4.3, 4.6) or very low-birthweight (16.8% vs. 3.2%, aRR 5.2, 95% CI 4.7, 5.8) infant. Among all twin pregnancies, 128 (6.9%) had at least one stillborn infant compared with 2845 (2.4%) stillbirths among singletons (aRR 2.8, 95% CI 2.3, 3.3). Conclusion: Adverse birth outcomes are common among twins in Botswana, and are often severe. Interventions that allow for earlier identification of twin gestation and improved antenatal management of twin pregnancies may improve infant and child survival.

scholarly journals Gestational Weight Gain and Adverse Birth Outcomes in Twin Pregnancies

2019 ◽  
Vol 134 (5) ◽  
pp. 1075-1086 ◽  
Author(s):  
Lisa M. Bodnar ◽  
Katherine P. Himes ◽  
Barbara Abrams ◽  
Timothy L. Lash ◽  
Sara M. Parisi ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Birth Outcomes ◽  
Adverse Birth Outcomes ◽  
Gestational Weight ◽  
Twin Pregnancies

Zygosity as a Risk Factor for Complications and Outcomes of Twin Pregnancy

1995 ◽  
Vol 44 (1) ◽  
pp. 11-23 ◽  
Author(s):  
R.E. Hoskins
Keyword(s):  
Gestational Diabetes ◽  
Birth Outcomes ◽  
Low Birthweight ◽  
Sudden Infant Death ◽  
Birth Certificates ◽  
Sudden Infant ◽  
Relative Risks ◽  
Estimated Risk ◽  
Mz Twins ◽  
Twin Pregnancies

AbstractAll of the recorded twin live births in Washington State birth certificates between 1984 and 1988 were used a retrospective cohort study to determine the risk of zygosity on pregnancy complications and birth outcomes (n = 3458). Relative risks comparing different sex (DS) twins to same sex (SS) twins were corrected to relative risks relating dizygotic (DZ) to monozygotic (MZ) twins, using the Weinberg rule. A higher proportion of DS twin pregnancies (3.5%) than SS pregnancies (1.6%) were complicated by gestational diabetes, resulting in an estimated risk for DZ twin pregnancies relative to MZ pregnancies of 8.6 (95% CI = 3.5-21.0). DZ twin pregnancies were at a lower risk for complications of polyhydraminios (RRDZ∣MZ = 0.2, 95% CI = 0.1-0.4) and of pyelonephritis, (RRDZ∣MZ = 0.3, 95% 0 = 0.1-0.8). MZ twins were more likely to have low birthweight and to have shorter gestations. The proportion of first-born babies of MZ twin pairs who died during their first year was similar to that of first twins of DZ pairs; however, the second-born of MZ twins were more likely to die in infancy than were second-born DZ pairs. First twins of DZ pairs were more likely to die of SIDS (sudden infant death syndrome) than the first of MZ twins (RRDZ∣MZ = 1.5, 95% CI = 0.4-5.1). In contrast, DZ second-born were less likely to die of SIDS than were MZ second-born twins (RRDZ∣MZ = 0.1, 95%CI = 0.1-0.7). DZ twins were less likely to have adverse newborn conditions or malformations. The high risk for gestational diabetes for DZ twin mothers is possibly due to the presence of two placentas which may support the development of greater insulin antagonism than the single placenta in the mother of MZ twins. The reduced risk of DZ relative to MZ twins for selected adverse birth outcomes may result from the increased tendency of MZ twins to be premature.

scholarly journals Prevalence and outcomes of twin pregnancies in Botswana: a national birth outcomes surveillance study

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e047553
Author(s):  
Arielle Isaacson ◽  
Modiegi Diseko ◽  
Gloria Mayondi ◽  
Judith Mabuta ◽  
Sonya Davey ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Birth Outcomes ◽  
Child Survival ◽  
Median Number ◽  
Adjusted Risk ◽  
Very Preterm ◽  
Tertiary Centre ◽  
Adjusted Risk Ratio ◽  
Stillborn Infant ◽  
Twin Pregnancies

ObjectivesThis study aims to evaluate the prevalence and outcome of twin pregnancies in Botswana.SettingThe Tsepamo Study conducted birth outcomes surveillance at 8 government-run hospitals (~45% of all births in Botswana) from August 2014 to June 2018 and expanded to 18 hospitals (~70% of all births in Botswana) from July 2018 to March 2019.ParticipantsData were collected for all live-born and stillborn in-hospital deliveries with a gestational age (GA) greater than 24 weeks. This analysis included 117 593 singleton and 3718 twin infants (1859 sets (1.6%)) born to 119 477 women between August 2014 and March 2019 and excluded 73 higher order multiples (23 sets of triplets and 1 set of quadruplets).Outcomes measuredOur primary outcomes were preterm delivery (<37 weeks GA), very preterm delivery (<32 weeks GA) and stillbirth (APGAR (Appearance, Pulse, Grimace, Activity, Respiration) score of 0, 0, 0).ResultsWomen with twin pregnancies had a similar median number of antenatal care visits (9 vs 10), but were more likely to deliver in a tertiary centre (54.8% vs 45.1%, p<0.001) and more likely to have a cesarean-section (54.6% vs 22.0%, p<0.001) than women with singletons. Compared with singletons, twin pregnancies had a higher risk of preterm delivery (<37 weeks GA) (47.6% vs 16.7%, adjusted risk ratio (aRR) 2.8, 95% CI 2.7 to 2.9) and very preterm delivery (<32 weeks) (11.8% vs 4.0%, aRR 3.0 95% CI 2.6 to 3.4). Among all twin pregnancies, 128 (6.9%) had at least one stillborn infant compared with 2845 (2.4%) stillbirths among singletons (aRR 2.8, 95% CI 2.3 to 3.3).ConclusionAdverse birth outcomes are common among twins in Botswana, and are often severe. Interventions that allow for earlier identification of twin gestation and improved antenatal management of twin pregnancies may improve infant and child survival.

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