Preparation andin vitroevaluation of propylthiouracil microspheres made of Eudragit RL 100 and cellulose acetate butyrate polymers using the emulsion-solvent evaporation method

2005 ◽  
Vol 22 (3) ◽  
pp. 281-289 ◽  
Author(s):  
W. M. Obeidat ◽  
J. C. Price
Keyword(s):  
Cellulose Acetate ◽  
Solvent Evaporation ◽  
Cellulose Acetate Butyrate ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Eudragit Rl ◽  
Acetate Butyrate

scholarly journals Effect of Solvent Evaporation Time and Casting Thickness on the Separation Performance of Cellulose Acetate Butyrate Blend Membrane

2019 ◽  
Vol 23 (2) ◽  
Author(s):  
Darvin Manimaran ◽  
Zeinab Abbas Jawad ◽  
Chew Thiam Leng
Keyword(s):  
Cellulose Acetate ◽  
High Performance ◽  
Solvent Evaporation ◽  
Cellulose Acetate Butyrate ◽  
Inversion Method ◽  
Separation Performance ◽  
Evaporation Time ◽  
Wet Phase Inversion ◽  
Carbon Dioxide Co2 ◽  
Acetate Butyrate

Global warming and climate change due to greenhouse gases (GHGs) emission, mostly carbon dioxide (CO2), have induced global efforts to minimize the concentration of atmospheric CO2. To reduce the effects of this problem, membrane technology is selected for the separation of CO2 due to the energy efficiency and economic advantages exhibited. In this study, the chosen polymeric material, cellulose acetate butyrate (CAB) is optimized using a wet phase inversion method with various molecular weight and different casting conditions due to its outstanding film-forming specifications and capabilities of fabricating a defect-free layer of neat membrane. The membrane was synthesized by blending three different molecular weights (Mn) of 12,000, 30,000 and 70,000 at different casting thickness, 150 µm to 300 µm and solvent evaporation time of 3.5 to 5 min. The results of these predominant parameters were then utilized to determine a high performance CAB membrane suitable for an enhanced CO2/Nitrogen (N2) separation. Eventually, a high separation performance CAB membrane was successfully synthesized with a CO2/N2 selectivity of 1.5819 ± 0.0775 when the solvent evaporation time and casting thickness was optimized at 4.5 min and 300 µm, respectively. Through this study, an improved understanding between membrane casting conditions and membrane performance has been achieved, for future development and progress.

scholarly journals Preparation and Evaluation of Cellulose Acetate Phthalate and Ethyl cellulose based Microcapsules of Diclofenac Sodium using Emulsification and Solvent-Evaporation Method

1970 ◽  
Vol 9 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Md Mominur Rahman ◽  
Md Saiful Islam ◽  
Nahid Sharmin ◽  
Jakir Ahmed Chowdhury ◽  
Reza-ul Jalil
Keyword(s):  
Hydrochloric Acid ◽  
Cellulose Acetate ◽  
Phosphate Buffer ◽  
Ethyl Cellulose ◽  
Diclofenac Sodium ◽  
Solvent Evaporation ◽  
Cellulose Acetate Phthalate ◽  
Solvent Evaporation Method ◽  
Solution Ph ◽  
Evaporation Method

Diclofenac sodium (DS) microspheres were prepared with two different polymers, ethyl cellulose (EC) and cellulose acetate phthalate (CAP). Emulsification-solvent evaporation method was used to prepare the microspheres. Liquid paraffin containing 1.5% (w/w) span 80 was the external phase and acetone-polymer solution was the internal phase. EC and CAP, both as single and as mixture, were used to encapsulate DS. EC microspheres were more spherical in shape and showed more entrapment efficiency than CAP microspheres. The size of the microspheres varied between 560-920 μm and as high as 90% loading efficiency was obtained. In vitro release study was carried out in 0.1 N hydrochloric acid solution (pH 1.2) for first 2 hours followed by in phosphate buffer solution (pH 6.8) for next 4 hours. After first 2 hours of dissolution in 0.1 N hydrochloric acid, EC microspheres released 24% of DS whereas CAP microspheres released only 2% DS. After 4 hours of dissolution in phosphate buffer, 60% DS was released from EC microspheres and almost all drug was released from CAP microspheres. Combination of EC and CAP showed more sustaining action than the individual polymer in both the dissolution media. DS release from EC microspheres followed Higuchi model whereas CAP microspheres followed first order model. Key word: Diclofenac sodium; microsphere; Ethyl cellulose; Cellulose acetate pthalate DOI: 10.3329/dujps.v9i1.7428 Dhaka Univ. J. Pharm. Sci. 9(1): 39-46 2010 (June)

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