Shared frailty model for recurrent event data with multiple causes

2011 ◽  
Vol 38 (12) ◽  
pp. 2859-2868 ◽  
Author(s):  
P. G. Sankaran ◽  
P. Anisha
2015 ◽  
Vol 26 (6) ◽  
pp. 2869-2884 ◽  
Author(s):  
Li-An Lin ◽  
Sheng Luo ◽  
Bingshu E Chen ◽  
Barry R Davis

Multi-type recurrent event data occur frequently in longitudinal studies. Dependent termination may occur when the terminal time is correlated to recurrent event times. In this article, we simultaneously model the multi-type recurrent events and a dependent terminal event, both with nonparametric covariate functions modeled by B-splines. We develop a Bayesian multivariate frailty model to account for the correlation among the dependent termination and various types of recurrent events. Extensive simulation results suggest that misspecifying nonparametric covariate functions may introduce bias in parameter estimation. This method development has been motivated by and applied to the lipid-lowering trial component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.


2012 ◽  
Vol 31 (11-12) ◽  
pp. 1162-1176 ◽  
Author(s):  
Yassin Mazroui ◽  
Simone Mathoulin-Pelissier ◽  
Pierre Soubeyran ◽  
Virginie Rondeau

Biometrics ◽  
2011 ◽  
Vol 67 (4) ◽  
pp. 1330-1339 ◽  
Author(s):  
Pang Du ◽  
Yihua Jiang ◽  
Yuedong Wang

Biometrics ◽  
2019 ◽  
Vol 76 (2) ◽  
pp. 448-459 ◽  
Author(s):  
Lili Wang ◽  
Kevin He ◽  
Douglas E. Schaubel

2019 ◽  
Vol 14 (5) ◽  
pp. 590-597 ◽  
Author(s):  
Richard Johnston ◽  
Roisin Cahalan ◽  
Laura Bonnett ◽  
Matthew Maguire ◽  
Alan Nevill ◽  
...  

Purpose: To determine the association between training-load (TL) factors, baseline characteristics, and new injury and/or pain (IP) risk in an endurance sporting population (ESP). Methods: Ninety-five ESP participants from running, triathlon, swimming, cycling, and rowing disciplines initially completed a questionnaire capturing baseline characteristics. TL and IP data were submitted weekly over a 52-wk study period. Cumulative TL factors, acute:chronic workload ratios, and exponentially weighted moving averages were calculated. A shared frailty model was used to explore time to new IP and association to TL factors and baseline characteristics. Results: 92.6% of the ESP completed all 52 wk of TL and IP data. The following factors were associated with the lowest risk of a new IP episode: (a) a low to moderate 7-d lag exponentially weighted moving averages (0.8–1.3: hazard ratio [HR] = 1.21; 95% confidence interval [CI], 1.01–1.44; P = .04); (b) a low to moderate 7-d lag weekly TL (1200–1700 AU: HR = 1.38; 95% CI, 1.15–1.65; P < .001); (c) a moderate to high 14-d lag 4-weekly cumulative TL (5200–8000 AU: HR = 0.33; 95% CI, 0.21–0.50; P < .001); and (d) a low number of previous IP episodes in the preceding 12 mo (1 previous IP episode: HR = 1.11; 95% CI, 1.04–1.17; P = .04). Conclusions: To minimize new IP risk, an ESP should avoid high spikes in acute TL while maintaining moderate to high chronic TLs. A history of previous IP should be considered when prescribing TLs. The demonstration of a lag between a TL factor and its impact on new IP risk may have important implications for future ESP TL analysis.


2014 ◽  
Vol 8 (1) ◽  
pp. 430-447 ◽  
Author(s):  
Doyo G. Enki ◽  
Angela Noufaily ◽  
C. Paddy Farrington

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