Media attention has highlighted the critical problem of concussion injuries in sport and the challenge of treating and rehabilitating individuals with traumatic brain injury. The authors present a framework for the treatment of traumatic brain injury, using low-resolution electromagnetic tomography Z-score based neurofeedback and heart rate–variability biofeedback. The article advocates a comprehensive assessment process including the use of a 19-channel quantitative electroencephalogram, a heart rate variability baseline, and symptom severity questionnaires for attention deficit/hyperactivity disorder, depression, and anxiety. The initial medical assessment, neuropsychological assessment, and evoked potential studies also have potential for a more precise assessment of deficits in brain activation patterns, which assists the targeting of neurofeedback training.