Working memory and processing speed among pediatric brain tumor patients treated with photon or proton beam radiation therapy

2018 ◽  
Vol 48 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Rachel K. Peterson ◽  
Jennifer M. Katzenstein
Keyword(s):  
Working Memory ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Processing Speed ◽  
Pediatric Brain Tumor ◽  
Tumor Patients ◽  
Beam Radiation ◽  
Proton Beam Radiation ◽  
Pediatric Brain ◽  
Proton Beam Radiation Therapy

IQ change within three years of radiation therapy in pediatric brain tumor patients treated with proton beam radiation therapy versus photon radiation therapy.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 10009-10009
Author(s):  
Lisa Kahalley ◽  
M. Fatih Okcu ◽  
M. Douglas Ris ◽  
David Grosshans ◽  
Arnold Paulino ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain Tumors ◽  
Tumor Patients ◽  
Beam Radiation ◽  
Proton Beam Radiation ◽  
Iq Scores ◽  
Pediatric Brain ◽  
Proton Beam Radiation Therapy

10009 Background: Radiation therapy (RT), an essential treatment for pediatric brain tumors, increases the risk of cognitive impairment. Advanced RT techniques reduce the volume of normal tissues receiving radiation dose. Proton beam radiation therapy (PBRT) minimizes irradiation to surrounding healthy brain tissue, with the potential to preserve cognitive function better than photon radiotherapy (XRT). We examined change in IQ over time between patients treated for pediatric brain tumors with PBRT versus XRT. Methods: IQ scores obtained in the first 3 years post-RT were abstracted for pediatric brain tumor patients treated with PBRT or XRT. Results: Baseline and follow-up IQ scores were available for 53 survivors (31 PBRT, 22 CRT). A linear regression model predicted follow-up IQ scores controlling for baseline IQ, age-at-RT, time-since-RT, and craniospinal irradiation (CSI), F(7,45)=23.4, p<.001. Follow-up IQ scores were significantly lower in the XRT group compared to the PBRT group (p<.05). The XRT group lost 10.3 IQ points on average with each additional year post-RT (p<.01), while the PBRT group remained stable, losing only 0.1 points per year on average (p<.05). CSI was associated with IQ decline in both groups (p<.05), while age-at-RT was not in either group (p=.154). Total RT dose was not associated with IQ with the above variables in the model. Conclusions: Findings suggest significant cognitive risk is associated with XRT, with IQ scores declining by more than half a standard deviation with each additional year post-RT. In contrast, IQ remained stable in the PBRT group. Preliminary findings suggest that PBRT may spare cognitive functioning in the first 3 years post-RT. Future research should replicate these findings with a larger sample and should study longer-term cognitive outcomes in patients treated with PBRT versus XRT. [Table: see text]

scholarly journals Working memory and attention in pediatric brain tumor patients treated with and without radiation therapy

2016 ◽  
Vol 23 (6) ◽  
pp. 642-654 ◽  
Author(s):  
Kimberly P. Raghubar ◽  
E. Mark Mahone ◽  
Keith Owen Yeates ◽  
Kim M. Cecil ◽  
Monwabisi Makola ◽  
...  
Keyword(s):  
Working Memory ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Pediatric Brain Tumor ◽  
Tumor Patients ◽  
Memory And Attention ◽  
Pediatric Brain

scholarly journals Improved neuropsychological outcomes following proton therapy relative to X-ray therapy for pediatric brain tumor patients

2019 ◽  
Vol 21 (7) ◽  
pp. 934-943 ◽  
Author(s):  
Jeffrey P Gross ◽  
Stephanie Powell ◽  
Frank Zelko ◽  
William Hartsell ◽  
Stewart Goldman ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Processing Speed ◽  
Adaptive Functioning ◽  
Pediatric Brain Tumor ◽  
Neuropsychological Evaluation ◽  
Tumor Patients ◽  
X Ray ◽  
Neuropsychological Outcomes ◽  
Pediatric Brain

AbstractBackgroundSurvivors of pediatric brain tumors are at risk for impaired development in multiple neuropsychological domains. The purpose of this study was to compare neuropsychological outcomes of pediatric brain tumor patients who underwent X-ray radiotherapy (XRT) versus proton radiotherapy (PRT).MethodsPediatric patients who underwent either XRT or PRT and received posttreatment age-appropriate neuropsychological evaluation—including measures of intelligence (IQ), attention, memory, visuographic skills, academic skills, and parent-reported adaptive functioning—were identified. Multivariate analyses were performed to assess differences in neuropsychological outcomes and included tests for interaction between treatment cohort and follow-up time.ResultsBetween 1998 and 2017, 125 patients with tumors located in the supratentorial (17.6%), midline (28.8%), or posterior fossa (53.6%) compartments received radiation and had posttreatment neuropsychological evaluation. Median age at treatment was 7.4 years. The PRT patient cohort had higher estimated SES and shorter median time from radiotherapy completion to last neuropsychological evaluation (6.7 vs 2.6 y, P < 0.001). On multivariable analysis, PRT was associated with higher full-scale IQ (β = 10.6, P = 0.048) and processing speed (β = 14.4, P = 0.007) relative to XRT, with trend toward higher verbal IQ (β = 9.9, P = 0.06) and general adaptive functioning (β = 11.4, P = 0.07). Planned sensitivity analyses truncating follow-up interval in the XRT cohort re-demonstrated higher verbal IQ (P = 0.01) and IQ (P = 0.04) following PRT, with trend toward improved processing speed (P = 0.09).ConclusionsPRT is associated with favorable outcomes for intelligence and processing speed. Combined with other strategies for treatment de-intensification, PRT may further reduce neuropsychological morbidity of brain tumor treatment.

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