Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T‐cell subsets and inflammatory cytokines

2008 ◽  
Vol 37 (3) ◽  
pp. 205-212 ◽  
Author(s):  
P. Szodoray ◽  
I. Gal ◽  
S. Barath ◽  
M. Aleksza ◽  
I. F. Horvath ◽  
...  
Keyword(s):  
T Cell ◽  
Inflammatory Cytokines ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
T Cell Subsets ◽  
Newly Diagnosed ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Immunological Alterations

scholarly journals Ileocecal junction perforation by colonic T-cell lymphoma in a patient with primary Sjögren’s syndrome

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989443
Author(s):  
Xiao-Chuan Liu ◽  
Zhi-Wei Jia ◽  
Yan Weng ◽  
Lian-Jun Yang ◽  
Jing Wang ◽  
...  
Keyword(s):  
T Cell ◽  
Sjögren's Syndrome ◽  
Cell Lymphoma ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
T Cell Lymphoma ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Primary Sjögren’s syndrome (pSS) is associated with an increased risk of lymphoma, especially non-Hodgkin’s lymphoma. The rarest pathological subtype is T-cell lymphoma. We herein report a case of a 52-year-old man with a 17-year history of pSS who was admitted to our hospital with chronic epigastric pain and a positive fecal occult blood test. Colonoscopy revealed multiple colonic ulcers, and histological and immunological studies demonstrated the T-cell origin of this lymphoma. However, the patient rejected all treatments. He developed recurrent intestinal obstruction and infection for 3 years until an intestinal perforation occurred. The right half of the colon was resected and colostomy was performed. However, the patient died of an intestinal fistula and intraperitoneal infection 40 days postoperatively. This case highlights the rarity of the correlation between T-cell lymphoma and pSS.

scholarly journals Characterization of a new regulatory CD4+ T cell subset in primary Sjogren's syndrome

Rheumatology ◽  
2013 ◽  
Vol 52 (8) ◽  
pp. 1387-1396 ◽  
Author(s):  
A. Alunno ◽  
M. G. Petrillo ◽  
G. Nocentini ◽  
O. Bistoni ◽  
E. Bartoloni ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Subset ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Cd4 T Cell ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
T Cell Subset

scholarly journals The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren’s Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Linbo Li ◽  
Jing He ◽  
Lei Zhu ◽  
Yuqin Yang ◽  
Yuebo Jin ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Activity ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Cell Populations ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Objective. Th17 cells have been demonstrated to play an important role in the onset and development of primary Sjögren’s syndrome (pSS). In this study, we evaluated the expansion and clinical significance of circulating CD4+CD161+ T cell and its “effector” (CD4+CD25−CD161+ T cell) and “regulatory” (CD4+CD25+CD161+ T cell) subpopulations.Methods. Fifty-eight pSS patients and 16 healthy controls (HCs) were recruited in our study. The cell populations and intracellular IL-17 expression were analyzed by flow cytometry. The disease activity was evaluated by the EULAR-SS Disease Activity Index (ESSDAI). Autoantibodies were measured by ELISA or indirect immunofluorescence assay.Results. The CD161+ T cell fractions showed higher proportions of IL-17-producing cells. The frequencies of the overall CD4+CD161+ T cell population and its effector subset were positively correlated with disease activity parameters and more severe disease manifestations. A significant elevation of the CD4+CD25+CD161+ T cell subpopulation was observed in the peripheral blood of pSS patients compared to HCs and this subset showed decreased regulatory functions compared with the CD4+CD25+CD161− population.Conclusion. Circulating CD4+CD161+ T cell populations associated with pSS disease activity and severity. These cells might be involved in the development of pSS and could be potential therapeutic targets in the treatment of pSS.

scholarly journals Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Gintaras Sudzius ◽  
Diana Mieliauskaite ◽  
Almantas Siaurys ◽  
Rita Viliene ◽  
Irena Butrimiene ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Population ◽  
Peripheral Blood ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Absolute Count ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Lymphocyte Populations

Purpose of this study was to evaluate the lymphocyte populations’ distribution changes in peripheral blood of patients with primary Sjögren’s syndrome (pSS). Lymphocyte populations’ distribution changes in peripheral blood of pSS patients were investigated in 52 patients with pSS and in 28 healthy controls by flow cytometry. We found decreased absolute count of CD3+T cell population in pSS patients. Analysis of CD4+T cell population showed significant proportion and absolute count differences in pSS patient’s blood with SSA/SSB antibodies (Abs) in comparison to controls. No significant differences were observed analyzing CD4+and CD8+Treg subpopulation. Proportion and absolute counts of Th17 cells were significantly lower in pSS patient’s blood. Absolute counts of CD8+T cells were significantly lower in pSS patients in comparison to controls and also impaired proportion and absolute counts of CD8+subpopulations according to CD27+and CD57+were observed. Absolute counts of NKT and NK cells were decreased in pSS with Abs. B cells proportion was increased only in blood of pSS with Abs. Lymphocyte distribution impairment can be due to genetically determined lymphopenia or lymphocyte migration from periphery to inflammatory sites or/and increased susceptibility to apoptosis.

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