On physical and antibacterial properties and drug release behavior of poly(vinyl alcohol) hydrogels: effect of drug loaded chitosan nanoparticles

2018 ◽  
Vol 58 (7) ◽  
pp. 732-741 ◽  
Author(s):  
F. Hosseini ◽  
M. Entezam ◽  
Seyed Hassan Jafari ◽  
Hossein-Ali Khonakdar ◽  
Majid Abdouss
Keyword(s):  
Drug Release ◽  
Vinyl Alcohol ◽  
Chitosan Nanoparticles ◽  
Antibacterial Properties ◽  
Poly Vinyl Alcohol ◽  
Release Behavior ◽  
Drug Release Behavior

scholarly journals Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yixiang Shi ◽  
Ajun Wan ◽  
Yifei Shi ◽  
Yueyue Zhang ◽  
Yupeng Chen
Keyword(s):  
Drug Release ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Solid Material ◽  
Loading Capacity ◽  
Simulation Studies ◽  
Release Behavior ◽  
Molecular Weights ◽  
Drug Release Behavior ◽  
Positively Charged

The study of drug release dynamic is aiming at understanding the process that drugs release in human body and its dynamic characteristics. It is of great significance since these characteristics are closely related to the dose, dosage form, and effect of the drugs. The Noyes-Whitney function is used to represent how the solid material is dissolved into solution, and it is well used in study of drug dynamic. In this research, aspirin (acetylsalicylic acid (ASA)) has been encapsulated with different grades of chitosan (CS) varying in molecular weight (Mw) for the purpose of controlled release. The encapsulation was accomplished by ionic gelation technology based on assembly of positively charged chitosan and negatively charged sodium tripolyphosphate (TPP). The encapsulation efficiency, loading capacity, and drug release behavior of aspirin loaded chitosan nanoparticles (CS-NPs) were studied. It was found that the concentration of TPP and Aspirin, molecular weights of chitosan have important effect on the drug release patterns from chitosan nanoparticles. The results for simulation studies show that the Noyes-Whitney equation can be successfully used to interpret the drug release characteristics reflected by our experimental data.

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