In Vitro and In Silico Evaluation of Betulin on Calcium Oxalate Crystal Formation

1. A low urinary magnesium was induced in normal volunteer subjects by giving cellulose phosphate; magnesium was added in vitro to yield urine samples of normal and high magnesium concentrations 2. After rapid evaporation of these urine samples at pH 5.3 to standard osmolality the calcium oxalate crystals were measured by microscopy and isotopic methods 3. There was a clear inverse correlation between magnesium concentration and calcium oxalate crystal formation 4. The case for treating calcium oxalate urolithiasis with magnesium is strengthened.

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In vitro and clinical study of oxalate influence on calcium oxalate crystal formation

Journal of Crystal Growth ◽

10.1016/0022-0248(88)90097-8 ◽

1988 ◽

Vol 87 (4) ◽

pp. 494-506 ◽

Cited By ~ 38

Author(s):

Y. Berland ◽

M. Olmer ◽

M. Grandvuillemin ◽

H.E. Lundager Madsen ◽

R. Boistelle

Keyword(s):

Clinical Study ◽

Calcium Oxalate ◽

Crystal Formation ◽

Calcium Oxalate Crystal

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The Inhibitory Effect of Sodium Pentosan Polysulfate on Calcium-Oxalate Crystal Formation in vitro and in vivo

Urolithiasis ◽

10.1007/978-1-4899-0873-5_54 ◽

1989 ◽

pp. 197-200

Author(s):

K. Miyazawa ◽

K. Suzuki ◽

R. Tsugawa

Keyword(s):

Calcium Oxalate ◽

Inhibitory Effect ◽

Crystal Formation ◽

Pentosan Polysulfate ◽

Calcium Oxalate Crystal ◽

Sodium Pentosan Polysulfate

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Correlation between Ion Composition of Oligomineral Water and Calcium Oxalate Crystal Formation

Crystals ◽

10.3390/cryst11121507 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1507

Author(s):

Manuela Rossi ◽

Biagio Barone ◽

Dante Di Domenico ◽

Rodolfo Esposito ◽

Antonio Fabozzi ◽

...

Keyword(s):

Calcium Oxalate ◽

Aqueous Medium ◽

Stone Formation ◽

Ionic Species ◽

Urinary Stone ◽

Crystal Formation ◽

Ion Composition ◽

Calcium Oxalate Crystal ◽

Ion Content

The ion content of drinking water might be associated with urinary stone formation, representing a keystone of conservative nephrolithiasis management. However, the effects of specific ions on calcium oxalate crystal formation and their mechanism of action are still highly controversial. We report an investigation of the effects of oligomineral waters with similar total salt amount but different ion composition on calcium oxalate (CaOx) precipitation in vitro, combining gravimetric and microscopic assays. The results suggest that the “collective” physicochemical properties of the aqueous medium, deriving from the ion combination rather than from a single ionic species, are of importance. Particularly, the ability of ions to strengthen/weaken the aqueous medium structure determines an increase/decrease in the interfacial energy, modulating the formation and growth of CaOx crystals.

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