DNA-binding, cleavage, antibacterial and in vitro anticancer activity of copper(II) mixed ligand complexes of 2-(((6-chloro-1H-benzo[d]imidazol-2-yl)methyl)amino)aceticacid and polypyridyl ligands

2021 ◽  
pp. 1-13
Author(s):  
Thatituri Sabithakala ◽  
Chittireddy Venkata Ramana Reddy
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Polypyridyl Ligands

DNA Binding Behavior, Sensor Studies, Antimicrobial, Photocleavage and In vitro Cytotoxicity of Synthesized Ru(II) Complexes with Assorted Intercalating Polypyridyl Ligands

2016 ◽  
Vol 26 (3) ◽  
pp. 1101-1113 ◽  
Author(s):  
Rajender Reddy Mallepally ◽  
Venkat Reddy Putta ◽  
Nagamani Chintakuntla ◽  
Ravi Kumar Vuradi ◽  
Laxma Reddy Kotha ◽  
...  
Keyword(s):  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Polypyridyl Ligands ◽  
Binding Behavior

scholarly journals Synthesis, Structure, and Anticancerous Properties of Silver Complexes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shraddha Shukla ◽  
A. P. Mishra
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Biology ◽  
Sequence Data ◽  
Analysis Data ◽  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Elemental Analysis Data

Although the “war on cancer” is now in its fourth decade and much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this dreaded disease, we still do not have a precise understanding of the differences between a cancer cell and its normal counterpart. The completion of the human genome sequence and its subsequent improvements in the sequence data are important steps to fully comprehend cancer cell biology. Ag(I) is being used as an anticancer agent in several human cancers. The anticancer activity of these complexes againstEhrlich’s ascitestumor cells (EACs) has been reported. The aim of the present study is to synthesize some new water soluble Ag(I) mixed ligand complexes containing nitrogen and sulfur base and to evaluate their biomedicinal properties. Mixed ligand complexes of Ag(I) metal derived from L-lysine and thiouracil with 2,2′-bipyridyl; 2-aminopyridine with thiouracil have been synthesized. The composition of the prepared complexes was discussed on the basis of microanalysis, FAB-mass, and FT-ir, measurements. Molecular weight was confirmed by FAB-mass spectra. The elemental analysis data suggest the stoichiometry to be M : L : L′ (1 : 1 : 1) ratio. These Ag(I) mixed ligand complexes showed excellent anticancer activity againstEhrlich’s ascitestumor cells (EACs).

In Vitro Study on DNA Binding of Ruthenium(II) Complexes with Polypyridyl Ligands

2009 ◽  
Vol 28 (9) ◽  
pp. 461-468 ◽  
Author(s):  
Li-Feng Tan ◽  
JianLiang Shen ◽  
XueJiao Chen ◽  
XiLing Liang
Keyword(s):  
Dna Binding ◽  
In Vitro Study ◽  
Vitro Study ◽  
Polypyridyl Ligands

One-pot synthesis, characterization, DNA binding and enzymatic studies of 4-methyl trans-cinnamate zinc(II)-mixed ligand complexes

2015 ◽  
Vol 68 (20) ◽  
pp. 3636-3650 ◽  
Author(s):  
Syeda Tahira Hafeez ◽  
Muhammad Nawaz Tahir ◽  
Saqib Ali ◽  
Muhammad Iqbal ◽  
Hussain Gulab ◽  
...  
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
One Pot ◽  
One Pot Synthesis
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