scholarly journals Synthesis, Structure, and Anticancerous Properties of Silver Complexes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shraddha Shukla ◽  
A. P. Mishra
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Biology ◽  
Sequence Data ◽  
Analysis Data ◽  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Elemental Analysis Data

Although the “war on cancer” is now in its fourth decade and much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this dreaded disease, we still do not have a precise understanding of the differences between a cancer cell and its normal counterpart. The completion of the human genome sequence and its subsequent improvements in the sequence data are important steps to fully comprehend cancer cell biology. Ag(I) is being used as an anticancer agent in several human cancers. The anticancer activity of these complexes againstEhrlich’s ascitestumor cells (EACs) has been reported. The aim of the present study is to synthesize some new water soluble Ag(I) mixed ligand complexes containing nitrogen and sulfur base and to evaluate their biomedicinal properties. Mixed ligand complexes of Ag(I) metal derived from L-lysine and thiouracil with 2,2′-bipyridyl; 2-aminopyridine with thiouracil have been synthesized. The composition of the prepared complexes was discussed on the basis of microanalysis, FAB-mass, and FT-ir, measurements. Molecular weight was confirmed by FAB-mass spectra. The elemental analysis data suggest the stoichiometry to be M : L : L′ (1 : 1 : 1) ratio. These Ag(I) mixed ligand complexes showed excellent anticancer activity againstEhrlich’s ascitestumor cells (EACs).

scholarly journals Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2′-Bipyridyl

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Sahar I. Mostafa ◽  
Farid A. Badria
Keyword(s):  
Aqueous Solution ◽  
Anticancer Activity ◽  
Tumor Cells ◽  
Mass Spectra ◽  
Mixed Ligand ◽  
Water Soluble ◽  
Ehrlich Ascites ◽  
Thermal Measurements ◽  
Complete Ionization

Synthesis of two new water-soluble mixed ligand [Pd(bpy)(dahmp)]Cl and [Ag(bpy)(Hdahmp)]NO3 complexes (dahmp and Hdahmp are the deprotonated monoanion and the protonated neutral 4,6-diamino-5-hydroxy-2-mercaptopyrimidine, resp.) is reported. The composition of the reported complexes was discussed on the bases of IR, H1 NMR, and mass spectra, as well as conductivity and thermal measurements. The reported complexes display a significant anticancer activity against Ehrlich ascites tumor cells (EACs). The higher activity of these complexes with their higher conductivity values corresponds to their complete ionization in aqueous solution.

scholarly journals Silver derivatives of multi-donor heterocyclic thioamides as antimicrobial/anticancer agents: unusual bio-activity against methicillin resistantS. aureus,S. epidermidis, andE. faecalisand human bone cancerMG63cell line

RSC Advances ◽  
2019 ◽  
Vol 9 (27) ◽  
pp. 15470-15487 ◽  
Author(s):  
Jaspreet K. Aulakh ◽  
Tarlok S. Lobana ◽  
Henna Sood ◽  
Daljit S. Arora ◽  
Raminderjit Kaur ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Mixed Ligand ◽  
Human Bone ◽  
Mixed Ligand Complexes ◽  
Line P ◽  
Derivatives Of ◽  
Heterocyclic Thioamides

A series of biosafe mixed-ligand complexes of silver with heterocyclic thioamides have been studied for their antimicrobial/anticancer activity.

New Water-Soluble Iridium(I)–N-Heterocyclic Carbene–Tertiary Phosphine Mixed-Ligand Complexes as Catalysts of Hydrogenation and Redox Isomerization

2014 ◽  
Vol 33 (22) ◽  
pp. 6330-6340 ◽  
Author(s):  
Henrietta Horváth ◽  
Ágnes Kathó ◽  
Antal Udvardy ◽  
Gábor Papp ◽  
Dorina Szikszai ◽  
...  
Keyword(s):  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Tertiary Phosphine ◽  
Redox Isomerization

Emerging Roles for von Willebrand Factor in Cancer Cell Biology

2017 ◽  
Vol 44 (02) ◽  
pp. 159-166 ◽  
Author(s):  
Roger Preston ◽  
Tracy Robson ◽  
James O'Donnell ◽  
Jamie O'Sullivan
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Von Willebrand Factor ◽  
Cell Biology ◽  
Tumor Metastasis ◽  
Human Tumor ◽  
Advanced Tumor Stage ◽  
Von Willebrand ◽  
Willebrand Factor

Abstractvon Willebrand factor (VWF) is a complex multimeric plasma glycoprotein that plays critical roles in normal hemostasis. However, additional novel roles for VWF in modulating cancer cell biology, and in particular tumor metastasis, have recently been reported. Markedly elevated plasma VWF levels were associated with advanced tumor stage and metastatic disease. These observations have raised the question of whether VWF may be involved in regulating tumor progression. Interestingly, novel findings indicate that VWF is expressed by a variety of tumor cells of nonendothelial origin. Critically, tumor cells that exhibit de novo acquired VWF expression demonstrate enhanced binding to endothelial cells (EC) and platelets, and increased extravasation through EC barriers. Furthermore, in vitro studies have shown that VWF can bind a variety of different tumor cells mediated by specific receptors expressed on the tumor cell surface. The concept that VWF is important in modulating tumor metastasis is further supported by in vivo experiments demonstrating that antibody-mediated VWF inhibition significantly attenuated murine metastasis. Intriguingly, however, VWF binding to specific human tumor cell lines results in apoptosis. In this study, the authors provide an overview of recent advances supporting a role for VWF in regulating multiple aspects of cancer cell biology.

scholarly journals Synthesis, spectroscopic, biological activities and DFT calculations of nickel(II) mixed-ligand complexes of tridentate Schiff bases

2020 ◽  
Vol 45 (1) ◽  
pp. 18
Author(s):  
Abidemi Iyewumi Demehin ◽  
Mary Adelaide Oladipo ◽  
Banjo Semire
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Biological Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Elemental Analysis Data ◽  
Biological Studies

Ni(II) mixed-ligand complexes of [NiLNH3] (where L= N-salicylidene-o-aminophenol (L1), N-(5-methoxysalicylidene-o-aminophenol) (L2) and N-(2-hydroxy-1-naphthalidene)-o-aminophenol) (L3) containing ONO tridentate Schiff bases and ammonia were synthesized and characterized by elemental analysis, infrared, ultraviolet-visible, proton and carbon-13 spectroscopies. Theoretical calculations were also performed on the optimized structures of the Ni(II) mixed-ligand complexes. The Infrared and ultraviolet-visible spectra of the complexes were calculated, and the results compared with the corresponding experimental spectra to augment the experimental structural identification. The elemental analysis data confirmed the formation of 1:1:1 [metal: Schiff base: ammonia] molar ratio. The NMR spectra showed that the Schiff bases coordinated to the Ni(II) ion via the two deprotonated phenolic oxygen and azomethine nitrogen atoms. The biological studies showed that the complexes exhibited higher antibacterial and antioxidant activities than the free Schiff base ligands.

scholarly journals Use of Nanoparticles for the Treatment of Malignant Neoplasm As a Cancer Targeted Drug Delivery System

2019 ◽  
Vol 7 (4) ◽  
pp. 84-88
Author(s):  
Mohammad Khan Gayoor ◽  
Umama Yezdani ◽  
Ayush Kumar ◽  
Mayur Sadar ◽  
Shorabh Rav ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Cell Biology ◽  
Sequence Data ◽  
Malignant Neoplasm ◽  
Rational Approach ◽  
Optimal Drug ◽  
Dreaded Disease

The current situation of Malignant Neoplasm is very different it’s the fourth decade and despite much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this dreaded disease, Malignant Neoplasm commonly known as (Cancer) till now we did not understand the actual difference between the cancer cell and its normal counterpart. If we did not understand we cannot control, eliminate, treat cancer. The human genome sequence and its subsequent improvements in the sequence data are important steps to fully comprehend cancer cell biology. The current recent advances in the understanding of pharmacokinetic & pharmacodynamic behaviour of drug have offered a more rational approach to the development of optimal drug delivery system. The novel drug delivery systems (NDDS) are carriers which maintain the drug concentration in therapeutic range for a longer period of time. Nanotechnology, a new, novel focus of research evolved from the convergence and coalescence of many diverse scientific disciplines which includes Nanomedicine will have an impact on the key challenges in cancer therapy: nanotubes, Nanopores, and nanoparticles are the most promising applications for various Malignant Neoplasm treatments.  

scholarly journals Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies

2018 ◽  
Vol 69 (11) ◽  
pp. 3169-3177 ◽  
Author(s):  
Karunganathan Sakthikumar ◽  
Murugesan Sankarganesh ◽  
Jeyaraj Dhaveethu Raja ◽  
Liviu Mitu
Keyword(s):  
Dna Cleavage ◽  
Free Ligand ◽  
Dna Interaction ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Molar Ratio ◽  
Spectral Techniques

A new series of water soluble mixed ligand complexes [MII(L)(bpy)AcO].nH2O M = Cu, (n=1) (1); Co (2), Mn (3), Ni (4) (n=4) and Zn (5) (n=2) have been synthesized from 2-(2-Morpholinoethylimino)methyl)phenol Schiff base ligand (HL) and 2,2�-bipyridine in a 1:1:1 molar ratio. The resulting complexes were characterized by spectral techniques. The spectral data of these complexes suggest an octahedral geometry. In vitro antioxidant activity results of DPPH assay, hydroxyl radical, super oxide and nitric oxide for complexes (1-5) were compared with ligand (HL) and in vitro antimicrobial activities of all compounds were examined against selected bacterial and fungal strains which indicate that the complexes exhibit higher antimicrobial activity than free ligand (HL). Gel electrophoresis results indicated that, complexes (1) and (2) have exhibited more DNA cleavage efficiency than others. The intrinsic binding constant (Kb) values for the complexes (1-5) observed by electronic absorption technique were in the order of (1) ] (4) ] (5) ] (2) ] (3) and DNA binding affinity values for these complexes obtained by viscosity measurements were in the order of ethidium bromide ] (1) ] (2) ] (3) ] (4) ] (5).

scholarly journals Synthesis and study of the anticancer activity of some new 7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazines

2021 ◽  
Vol 14 (3) ◽  
pp. 320-327
Author(s):  
I. I. Myrko ◽  
T. I. Chaban ◽  
V. V. Ohurtsov ◽  
I. V. Drapak ◽  
V. S. Matiichuk
Keyword(s):  
Nmr Spectroscopy ◽  
Anticancer Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Anticancer Agents ◽  
1H Nmr Spectroscopy ◽  
Analysis Data ◽  
Elemental Analysis Data ◽  
Tumor Cell Death ◽  
Secondary Stage

The problem of finding effective low-toxic anticancer agents is one of the most important in modern medicine and pharmacy. Despite a large selection of anticancer drugs and a variety of mechanisms of their action, the effectiveness of existing drugs continues to be insufficient. Among the numerous natural and synthetic heterocyclic compounds that exhibit anticancer activity, 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives, which are able to initiate different pathways of tumor cell death. Based on this, the synthesis of new derivatives of this class of compounds and the study of their anticancer properties is relevant. The aim of the work is to synthesis of new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and study their anticancer activity. Materials and methods. It was used methods of organic synthesis, physical and chemical methods of analysis organic compounds (1H NMR spectroscopy, elemental analysis). Results. In order to obtain new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, the interaction implemented of 4-amino-4H-[1,2,4]triazole-3-thiols with the corresponding bromoacetophenones. The reaction proceeds by heating the above reagents in alcohol with the closure of the thiadiazine ring and the formation of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine systems. The structure of all synthesized compounds was confirmed by 1H NMR spectroscopy and elemental analysis data. The study of the anticancer activity of the synthesized compounds was carried out in the framework of the international scientific program DTP (Developmental Therapeutics Program) of the National Cancer Institute (NCI, Bethesda, Maryland, USA). It was found that the synthesized compounds exhibited different levels of anticancer activity. The most active among the tested substances was compound 3j with an average GP value of 28.73. The most sensitive to it were the lines of melanoma MDA-MB-435 and SK-MEL-2, kidney cancer A498 and RXF 393, CNS cancer SNB-75, and non-small cell lung cancer NCI-H522. The secondary stage of studies of this compound confirmed its high anticancer activity against most cancer cell lines. Conclusions. As a result of the interaction of 4-amino-4H-[1,2,4]triazole-3-thiols with the relevant bromoacetophenones, a series of new triazolo[3,4-b][1,3,4]thiadiazines was not described in the literature was synthesized. Testing the synthesized compounds for the antitumor activity made it possible to isolate 1 highly active compound with a pronounced anticancer effect, which in terms of activity approaches or exceeds the known drugs 5-fluorouracil (5-FU) and cisplatin, as well as an anticancer agent, curcumin.  

Influence of N atom number and form on the photodynamic activities of zinc phthalocyanines

2016 ◽  
Vol 20 (05) ◽  
pp. 602-614
Author(s):  
Wei W. Jin ◽  
Yue Wang ◽  
Ao Wang ◽  
Lin Zhou ◽  
Yun Lin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Anticancer Activity ◽  
Cancer Cell ◽  
Water Solubility ◽  
Water Soluble ◽  
Amino Group ◽  
Oxygen Species ◽  
Atom Number ◽  
Zinc Phthalocyanines

Amino group modified phthalocyanines (Pcs) and their derivatives have attracted great attention in the field of photodynamic therapy (PDT) because of their satisfied anticancer activity. The existence of N atoms in these Pcs is very important because they not only provide water solubility of Pcs, but also greatly affect their PDT activity. To clear the influence of N atoms number on PDT activity of amino group modified Pcs and their derivatives, in this manuscript, two series of amine modified Pcs with different N atom number and their water soluble derivatives, hydrochloride and quaternizing derivatives were synthesized. Their photochemical and photobiology properties were studied and compared. The results indicated that with increasing the number on N atom, the reactive oxygen species (ROSs) generation ability, cancer cell uptaken ability and photoinduced anticancer activity were all increased in these ZnPcs.

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