This paper describes a preliminary investigation that identified factors important in the prediction of river water quality, especially regarding dissolved oxygen (DO) concentration. Intermittent discharges from combined sewer overflows (CSOs) within the sewerage, and overflows at water reclamation works (WRW) cause dynamic conditions with respect to both river hydraulics and water quality. The impact of such discharges has been investigated under both wet and dry weather flow conditions. Data collected from the River Maun, UK, has shown that an immediate, transient oxygen demand exists downstream of an outfall during storm conditions. The presence of a delayed oxygen demand has also been identified. With regard to modelling, initial investigations used a simplified channel and the Streeter-Phelps (1925) dissolved oxygen sag curve equation. Later, a model taking into account hydrodynamic, transport and dispersion processes was used. This suggested that processes other than water phase degradation of organic matter significantly affect the dissolved oxygen concentration downstream of the location of an intermittent discharge. It is proposed that the dynamic rate of reaeration and the sediment oxygen demand should be the focus of further investigation.