Immunogenicity of branched polyethylene glycol modified interferon alpha

2017 ◽  
Vol 40 (1) ◽  
pp. 35-42
Author(s):  
Weidong Zhou ◽  
Daru Lu ◽  
Xiaojin Liao ◽  
Lu Zhuang ◽  
Li Sun
Keyword(s):  
Polyethylene Glycol ◽  
Interferon Alpha ◽  
Branched Polyethylene

scholarly journals Cutaneous Necrosis after Subcutaneous Injection of Polyethylene-Glycol-modified Interferon alpha

2002 ◽  
Vol 82 (4) ◽  
pp. 310-312 ◽  
Author(s):  
Hjalmar Kurzen ◽  
Wolfgang Hartschuh ◽  
Uta Jappe ◽  
Detlef Petzoldt
Keyword(s):  
Polyethylene Glycol ◽  
Interferon Alpha ◽  
Subcutaneous Injection ◽  
Cutaneous Necrosis

scholarly journals Treatment of Hepatitis C Infections with Interferon: A Historical Perspective

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Robert M. Friedman ◽  
Sara Contente
Keyword(s):  
Hepatitis C Virus ◽  
Polyethylene Glycol ◽  
Hepatitis C ◽  
Interferon Alpha ◽  
Historical Perspective ◽  
Disease Treatment ◽  
Future Treatment ◽  
Near Future

Interferons were first described in 1957, but it was not until 34 years after their discovery that sufficient quantities of it were available for treatment of hepatitis C virus (HCV) infections, Clinicians now have an excellent understanding of the basis for the effectiveness of interferon alpha (IFN-) in the therapy of this disease. Treatment with IFN- is more efficient when it complemented by the antiviral ribavirin and the IFN- is conjugated with polyethylene glycol to form peginterferon. In the near future treatment of HCV with IFN- may involve new anti-HCV agents that are currently under development.

scholarly journals Interferon to PEG-Interferon: A Review

1970 ◽  
Vol 17 (2) ◽  
pp. 113-116 ◽  
Author(s):  
MA Ahad ◽  
MA Alim ◽  
ARM Saifuddin Ekram
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Interferon Alpha ◽  
Half Life ◽  
Pegylated Interferon ◽  
Therapeutic Benefits ◽  
Naturally Occurring ◽  
Recombinant Technology ◽  
Mammalian Immune System

The interferons (IFNs) are group of naturally occurring cytokines that are secreted by cells of mammalian immune system when they are stimulated by viral, bacterial and other antigens. There are number of alpha IFNs available for treatment purposes. The two most commonly used α-2a and α-2b are made by recombinant technology. When interferon Alpha-2a is combined with polyethylene glycol (PEG), it is known as pegylated interferon or PEG interferon. Polyethylene glycol (PEG) is a safe, inert and nontoxic molecule. Therapeutic benefits of altering proteins with PEG include an improvement in half-life due to reduced renal and cellular clearance, enhanced protection from proteolysis and a reduction in toxicity.   doi: 10.3329/taj.v17i2.3460   TAJ 2004; 17(2): 113-116

Rational Design of a Potent, Long-Lasting Form of Interferon:  A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C

2001 ◽  
Vol 12 (2) ◽  
pp. 195-202 ◽  
Author(s):  
Pascal Bailon ◽  
Alicia Palleroni ◽  
Carol A. Schaffer ◽  
Cheryl L. Spence ◽  
Wen-Jian Fung ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Hepatitis C ◽  
Rational Design ◽  
Interferon Α ◽  
Branched Polyethylene

scholarly journals Branched polyethylene glycol/polypropylene micro-nanofiber nonwovens for fast liquid planar transmission

2019 ◽  
Vol 14 ◽  
pp. 155892501985079 ◽  
Author(s):  
Heng Zhang ◽  
Qi Zhen ◽  
Yong Liu ◽  
Rangtong Liu ◽  
Yifeng Zhang
Keyword(s):  
Polyethylene Glycol ◽  
Formation Mechanism ◽  
Wound Dressings ◽  
Engineering Applications ◽  
Liquid Filtration ◽  
Branched Polyethylene ◽  
Transmission Properties ◽  
Wide Range ◽  
Branched Structures ◽  
Die Temperature

The speed of liquid planar transmission plays a key role in engineering applications, including baby wipes, wound dressings, and liquid filtration. This article reported a novel branched nonwoven consisting of melt-blown polyethylene glycol/polypropylene micro- and nanofibers. The formation mechanism of branched structures as well as the liquid planar transmission properties of the prepared polyethylene glycol/polypropylene micro-nanofibrous nonwovens was discussed in detail. The results showed that the diameter of melt-blown fibers could be controlled by changing the percentage of polyethylene glycol (0–15 wt%) and die temperature (230°C–250°C). Furthermore, micro- and nanofibers, which had three types of size: >2 μm, 800 nm–2 μm, and <800 nm, formed a three-level branched network, which greatly improved the liquid planar transmission capacity. This work suggested that the branched micro/nanofiber nonwovens could be employed in a wide range of potential engineering applications.

scholarly journals Novel drug for COVID-19: Virafin a therapeutic breakthrough

2021 ◽  
Vol 8 (1) ◽  
pp. 12-14
Author(s):  
J Robinson ◽  
I Banerjee ◽  
B Roy ◽  
A Leclézio
Keyword(s):  
Polyethylene Glycol ◽  
Interferon Alpha ◽  
Oxygen Therapy ◽  
Pegylated Interferon ◽  
Janus Kinase ◽  
Human Interferon ◽  
Pegylated Interferon Alpha ◽  
Interferon Alpha 2B ◽  
Interferon Receptor ◽  
2B Protein

Background: Pegylated Interferon Alpha-2b is synthesized via the use of PEG (polyethylene glycol). It is formulated via attaching a 12kDa mono methoxy polyethylene glycol moiety to the recombinant human Interferon Alpha-2b protein. Pegylated Interferon Alpha-2b acts via binding to the (JAK/STAT) Janus kinase signal transducer and activator of the transcription interferon receptor. The Pegylated Interferon Alpha-2b /Virafin binds to the (IFNAR1/2) alpha interferon receptor 1 and 2. Pegylated Interferon Alpha-2b better known as Virafin has been approved by the Drugs Controller General of India. This therapeutic agent is currently under a multicentric phase 3 trial with very promising results being reported. A single subcutaneous dose of Virafin has been shown to decrease the need for oxygen therapy in patients. This reduction in the need for oxygen therapy is a vital factor needed to provide relief to the Indian medical system in light of the recent oxygen shortages faced due to India’s worst wave of COVID-19 cases since the onset of the global pandemic. Pegylated Interferon Alpha-2b/ Virafin confers enhanced viral clearance and bolsters the immune response to induce a quicker recovery in patients with mild to moderate symptoms. Conclusion: It is of paramount importance that further research on Virafin is undertaken as it can hinder the progression of COVID-19, reduce pressure on the inundated health systems, and save countless lives.

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