Efficacy of Guduchi Swarasa (Bhavaprakasa) in the Management of Madhumeh

Nowadays due to change in lifestyle, a human beings is attracting many diseases because of poor quality of food, eating more than necessary, sleeping during day time, eating fast food and improved stress in society. Madhumeha can be linked with Diabetes mellitus in modern medicine, which is attracting the whole world as a non-infectious epidemic. A total of 25-patients with classical symptoms of Madhumeh, irrespective of sex, occupation, etc was chosen for the clinical trial. The assessment was done on the basis of evolution in Rogabala, Dehabala, Chetasabala, and Agnibala by specific scoring patterns. The results were analyzed statistically by Paired t-test. In symptom-wise statistical analysis, it is seen that Guduchi Swarasa is significantly effective in the symptoms of Madhumeha. Guduchi Swarasa has major hypoglycemic action and it is more on post-meal blood sugar level.

Products of Sericulture and Their Hypoglycemic Action Evaluated by Using the Silkworm, Bombyx mori (Lepidoptera: Bombycidae), as a Model

Sericulture generates different natural products with potential medical applications. Silk peptides, worms, or even pupae are commonly employed in traditional Asian medicine with a wide variety of purposes, and some scientific work has been focused on their antidiabetic properties. This work evaluates the postprandial antihyperglycemic activity of fibroin, sericin, and powder made from either larvae or pupae of silkworms, and Bombyx mori L. (Lepidoptera: Bombycidae), employing the silkworm itself as an animal model. The results indicate a reduction in the glucose levels in hemolymph after sucrose or glucose-induced hyperglycemia when these products are included in the diet of the worms.

Research in phytochemical composition and hypoglycemic activity screening of the dry extracts from bearberry leaves

Diabetes mellitus is a global medical and social issue. In the developed countries of the world, from 5 to 12% of the population are diagnosed with diabetes mellitus and, according to WHO prognosis, the level of this disease may increase to 30-35%. Type 2 diabetes is a disease that progresses over time, but the rational and systematic use of hypoglycemic synthetic drugs and phytopreparations can significantly delay the onset of insulin therapy. A promising source of BAS with a hypoglycemic effect is the raw material of plants of the Heather family, namely, bearberry leaves. However, on the Ukrainian market there are no domestic galenic and novo-galenic preparations based on biologically active substances of this raw material, which indicates the prospects for the development of new drugs, including those with hypoglycemic action. The aim. The aim of the study was to study the phytochemical composition and to carry out a screening of the hypoglycemic activity of dry extracts from bearberry leaves modified with various amino acids to identify promising substances with hypoglycemic action. Materials and methods. The objects of the study were 11 dry extracts from bearberry leaves, 10 of which were modified with various amino acids. The study of the phenolic compounds of the extracts was carried out by TLC, HPLC, and spectrophotometry. To assess the hypoglycemic activity of the extracts, two experiments were carried out - primary screening and oral glucose tolerance test. Results. Using TLC and HPLC, in the extracts obtained arbutin, gallic acid, 5 flavonoids were identified, among which hyperoside was dominant, 4 hydroxycinnamic acids, among which chlorogenic and caffeic acids were dominant, and their content was established. In the extracts obtained, main groups of phenolic compounds were quantified using a spectrophotometric method. Dry extracts from bearberry leaves, modified with cysteine, arginine and glutamic acid, showed the strongest hypoglycemic activity. Conclusions. The chemical composition of phenolic compounds and the hypoglycemic activity of dry extracts from bearberry leaves modified with 10 different amino acids were determined. The most promising substances turned out to be extracts modified with cysteine, arginine and glutamic acid; therefore, they are promising agents for the development of new drugs.

A Comprehensive Study of Medicinal Plants with Antidiabetic Properties

The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. Herbal medicine has grown in popularity in both developing and developed countries over the last several years, owing to its natural origins and lack of negative effects. Even though medicinal plants have been utilized to treat diabetes mellitus from ancient times, they have been offered as abundant but untapped prospective sources for anti-diabetic medicines. It's a reality that diabetes can't be cured, and no one has ever claimed to be completely free of the disease. Diabetes mellitus is becoming a severe hazard to human health in all regions of the world due to its fast growing occurrence. Furthermore, several novel bioactive compounds derived from plants have demonstrated antidiabetic action with greater efficacy than oral hypoglycemic medicines already utilized in clinical therapy in recent years. Despite the fact that many plants are recommended, further pharmacological and chemical study is needed to fully understand the mechanism of hypoglycemic action.

Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats

Syzygium cumini (L.) Skeels was adapted to the climatic conditions and soil types in Brazil. Its fruits, leaves and inner bark are used in folk medicine due to their high antioxidant, anti-inflammatory, anticarcinogenic and antidiabetic activities mainly associated with the presence of phenolic compounds. It is estimated that at least 300 million people worldwide develop diabetes and approximately 11 million people are carriers of the disease in Brazil. The objective of this work was to evaluate the in vitro antioxidant activity, as well as the hypoglycemic action of hydroethanolic extract (HEE), the ethyl acetate (EAF) and hydromethanolic (HMF) fractions from leaves of S. cumini (L.) Skeels in rats. All assays were carried out in three replications. Data were expressed as mean ± SD and significance was evaluated by ANOVA and Bonferroni test (p < 0.05). The results indicate a significant (p < 0.05) total phenol content (207 ± 2.3 GAE mg g-1) and antioxidant activity (EC50 = 9.05 ± 0.170 µg mL-1) for EAF. HEE and its fractions showed no significant (p > 0.05) action to modulate glucose by the OGTT assay in nondiabetic mice compared to control. Thus the use of the plant against diabetes in individuals is not proven.

A Review on Neuroprotective Effects of Almonds

Almonds are prunes belonging to the family Rosaceae. Almonds are the most popular and very commonly used nuts. These nuts are extremely beneficial included properties of alpha-tocopherol, vitamin E, sucrose, phenolics, folate, brain tryptophan mono and polyunsaturated fatty acids. It is well known that almonds are protective, and preventive nuts for various diseases. The mechanisms have proven its effects in various body systems and functions like immunostimulation, antioxidant action, hypoglycemic action, prebiotic potentials, cholesterol levels, hepatoprotective, and neuroprotective. Therefore, this study aims to review the neuroprotective functions of almonds, and a literature search was done in Pub Med, Google Scholar and Science Direct. From the selected database reviews about the neuroprotective effects of almonds were discussed. It is proven that the natural antioxidant property of almonds is said to be neuroprotective. The regular consumption of almonds in diet is said to increase the memory. The few review articles on neural effects of almonds have proven almond to be very effective and neuroprotective in nature compared to the other nuts. Therefore, it is recommended that dietary intake of almonds does not only have effects on cholesterol levels known previously it has major effects in developing and maintaining the neural mechanism.