Synthesis and cytotoxic activity of platinum complex immobilized by branched polyethylene glycol

2005 ◽  
Vol 15 (20) ◽  
pp. 4479-4483 ◽  
Author(s):  
Yong Ren ◽  
Haitao Zhang ◽  
Junlian Huang
Keyword(s):  
Polyethylene Glycol ◽  
Cytotoxic Activity ◽  
Platinum Complex ◽  
Branched Polyethylene

scholarly journals Synthesis, Characterization and Cytotoxic Activity of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide and Its Pt(II) Complex

2019 ◽  
pp. 1-12
Author(s):  
Nasser Mohammed Hosny ◽  
Lamiaa A. A. Barakat
Keyword(s):  
Cytotoxic Activity ◽  
Anthranilic Acid ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Ehrlich Ascites Carcinoma ◽  
Morphological Characterization ◽  
Spherical Particles ◽  
Spectral Techniques ◽  
Average Size

Since the discovery of the platinum based complex, cisplatin, medicinal inorganic chemistry has attracted much more attention and a large number of platinum complexes with promising pharmacological properties have been synthesized. In this work a new platinum complex of N-(5-indanyl(methylene)anthranilic acid(5-indanyl methylene)-hydrazide (HL) has been synthesized and characterized by physical and spectral techniques, as elemental analysis, IR, EI-MS, 1H-NMR, thermal analysis, transmittance electron microscope (TEM) and magnetic moment. The results indicated that the ligand binds to Pt(II) in the enol form. Square-planar stereochemistry was suggested for the Pt(II) complex. The morphological characterization showed nano-sized spherical particles with average size 92 nm of the isolated complex. The synthesized Pt(II) complex exhibited a significant cytotoxic activity against HCT116 and HEPG2. Also in vivo study of the Pt(II) complex showed cytotoxic activity towards Ehrlich ascites carcinoma (EAC).

Immunogenicity of branched polyethylene glycol modified interferon alpha

2017 ◽  
Vol 40 (1) ◽  
pp. 35-42
Author(s):  
Weidong Zhou ◽  
Daru Lu ◽  
Xiaojin Liao ◽  
Lu Zhuang ◽  
Li Sun
Keyword(s):  
Polyethylene Glycol ◽  
Interferon Alpha ◽  
Branched Polyethylene

Rational Design of a Potent, Long-Lasting Form of Interferon:  A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C

2001 ◽  
Vol 12 (2) ◽  
pp. 195-202 ◽  
Author(s):  
Pascal Bailon ◽  
Alicia Palleroni ◽  
Carol A. Schaffer ◽  
Cheryl L. Spence ◽  
Wen-Jian Fung ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Hepatitis C ◽  
Rational Design ◽  
Interferon Α ◽  
Branched Polyethylene

scholarly journals Branched polyethylene glycol/polypropylene micro-nanofiber nonwovens for fast liquid planar transmission

2019 ◽  
Vol 14 ◽  
pp. 155892501985079 ◽  
Author(s):  
Heng Zhang ◽  
Qi Zhen ◽  
Yong Liu ◽  
Rangtong Liu ◽  
Yifeng Zhang
Keyword(s):  
Polyethylene Glycol ◽  
Formation Mechanism ◽  
Wound Dressings ◽  
Engineering Applications ◽  
Liquid Filtration ◽  
Branched Polyethylene ◽  
Transmission Properties ◽  
Wide Range ◽  
Branched Structures ◽  
Die Temperature

The speed of liquid planar transmission plays a key role in engineering applications, including baby wipes, wound dressings, and liquid filtration. This article reported a novel branched nonwoven consisting of melt-blown polyethylene glycol/polypropylene micro- and nanofibers. The formation mechanism of branched structures as well as the liquid planar transmission properties of the prepared polyethylene glycol/polypropylene micro-nanofibrous nonwovens was discussed in detail. The results showed that the diameter of melt-blown fibers could be controlled by changing the percentage of polyethylene glycol (0–15 wt%) and die temperature (230°C–250°C). Furthermore, micro- and nanofibers, which had three types of size: >2 μm, 800 nm–2 μm, and <800 nm, formed a three-level branched network, which greatly improved the liquid planar transmission capacity. This work suggested that the branched micro/nanofiber nonwovens could be employed in a wide range of potential engineering applications.

Branched Polyethylene Glycol (Bpeg) Conjugated Antisense Oligonucleotides

1998 ◽  
Vol 17 (9-11) ◽  
pp. 1567-1570 ◽  
Author(s):  
B. Burcovich ◽  
F. M. Veronese ◽  
V. Zarytova ◽  
G. M. Bonora
Keyword(s):  
Polyethylene Glycol ◽  
Antisense Oligonucleotides ◽  
Branched Polyethylene
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