Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells

2014 ◽  
Vol 79 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Shu-Mei Lee ◽  
Shu-Hua Chiang ◽  
Hsun-Yen Wang ◽  
Pey-Shiuan Wu ◽  
Chih-Chien Lin
Keyword(s):  
Human Fibroblast ◽  
Elastic Fibers ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Structural Components ◽  
Human Fibroblast Cells ◽  
Fibrillin 1 ◽  
Normal Human

G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation

2004 ◽  
Vol 104 (1-4) ◽  
pp. 211-215 ◽  
Author(s):  
T. Kawata ◽  
H. Ito ◽  
T. Uno ◽  
M. Saito ◽  
S. Yamamoto ◽  
...  
Keyword(s):  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Human Fibroblast Cells ◽  
High Let Radiation ◽  
High Let ◽  
Normal Human

scholarly journals Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation

2004 ◽  
Vol 45 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Mitsuaki OJIMA ◽  
Hiroki HAMANO ◽  
Masatoshi SUZUKI ◽  
Keiji SUZUKI ◽  
Seiji KODAMA ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Human Fibroblast Cells ◽  
Normal Human

Reactivity trends of cobalt(III) complexes towards various amino acids based on the properties of the amino acid alkyl chains

2020 ◽  
Vol 76 (7) ◽  
pp. 663-672
Author(s):  
Charmaine Arderne ◽  
Kyle Fraser Batchelor ◽  
Bhawna Uprety ◽  
Rahul Chandran ◽  
Heidi Abrahamse
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Alkyl Chains ◽  
Human Fibroblast Cells ◽  
Vis Spectroscopy ◽  
Normal Human

The reactivity of the cobalt(III) complexes dichlorido[tris(2-aminoethyl)amine]cobalt(III) chloride, [CoCl2(tren)]Cl, and dichlorido(triethylenetetramine)cobalt(III) chloride, [CoCl2(trien)]Cl, towards different amino acids (L-proline, L-asparagine, L-histidine and L-aspartic acid) was explored in detail. This study presents the crystal structures of three amino acidate cobalt(III) complexes, namely, (L-prolinato-κ2 N,O)[tris(2-aminoethyl)amine-κ4 N,N′,N′′,N′′′]cobalt(III) diiodide monohydrate, [Co(C5H8NO2)(C6H18N4)]I2·H2O, I, (L-asparaginato-κ2 N,O)[tris(2-aminoethyl)amine-κ4 N,N′,N′′,N′′′]cobalt(III) chloride perchlorate, [Co(C4H7N2O3)(C6H18N4)](Cl)(ClO4), II, and (L-prolinato-κ2 N,O)(triethylenetetramine-κ4 N,N′,N′′,N′′′)cobalt(III) chloride perchlorate, [Co(C4H7N2O3)(C6H18N4)](Cl)(ClO4), V. The syntheses of the complexes were followed by characterization using UV–Vis spectroscopy of the reaction mixtures and the initial rates of reaction were obtained by calculating the slopes of absorbance versus time plots. The initial rates suggest a stronger reactivity and hence greater affinity of the cobalt(III) complexes towards basic amino acids. The biocompatibility of the complexes was also assessed by evaluating the cytotoxicity of the complexes on cultured normal human fibroblast cells (WS1) in vitro. The compounds were found to be nontoxic after 24 h of incubation at concentrations up to 25 mM.

scholarly journals Human Microfibrillar-Associated Protein 4 (MFAP4) Gene Promoter: A TATA-Less Promoter That Is Regulated by Retinol and Coenzyme Q10 in Human Fibroblast Cells

2020 ◽  
Vol 21 (21) ◽  
pp. 8392
Author(s):  
Ying-Ju Lin ◽  
An-Ni Chen ◽  
Xi Jiang Yin ◽  
Chunxiang Li ◽  
Chih-Chien Lin
Keyword(s):  
Coenzyme Q10 ◽  
Elastic Fiber ◽  
Gene Promoter ◽  
Fiber Formation ◽  
Elastic Fibers ◽  
Structural Components ◽  
Connective Tissues ◽  
Human Fibroblast Cells ◽  
Fibrillin 1 ◽  
Species Specific

Elastic fibers are one of the major structural components of the extracellular matrix (ECM) in human connective tissues. Among these fibers, microfibrillar-associated protein 4 (MFAP4) is one of the most important microfibril-associated glycoproteins. MFAP4 has been found to bind with elastin microfibrils and interact directly with fibrillin-1, and then aid in elastic fiber formation. However, the regulations of the human MFAP4 gene are not so clear. Therefore, in this study, we firstly aimed to analyze and identify the promoter region of the human MFAP4 gene. The results indicate that the human MFAP4 promoter is a TATA-less promoter with tissue- and species-specific properties. Moreover, the promoter can be up-regulated by retinol and coenzyme Q10 (coQ10) in Detroit 551 cells.

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