Neurodevelopmental assessment at one year of age predicts neuropsychological performance at six years in a cohort of West African Children

2021 ◽  
Vol 27 (4) ◽  
pp. 548-571
Author(s):  
Michael J. Boivin ◽  
Roméo Zoumenou ◽  
Alla Sikorskii ◽  
Nadine Fievet ◽  
Jules Alao ◽  
...  
Author(s):  
Lucie Paloque ◽  
Romain Coppée ◽  
Barbara H. Stokes ◽  
Nina F. Gnädig ◽  
Karamoko Niaré ◽  
...  

Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum k13 ( pfk13 ) gene. Here, we carried out in vitro selection over a one-year period on a West African P. falciparum strain isolated from Kolle (Mali) under a dose-escalating artemisinin regimen. After 18 cycles of sequential drug pressure, the selected parasites exhibited enhanced survival to dihydroartemisinin in the ring-stage survival assay (RSA 0-3h = 9.2%). Sanger and whole-genome sequence analyses identified the PfK13 P413A mutation, localized in the BTB/POZ domain, upstream of the propeller domain. This mutation was sufficient to confer in vitro artemisinin resistance when introduced into the PfK13 coding sequence of the parasite strain Dd2 by CRISPR/Cas9 gene editing. These results together with structural studies of the protein demonstrate that the propeller domain is not the sole in vitro mediator of PfK13-mediated artemisinin resistance, and highlight the importance of monitoring for mutations throughout PfK13.


2015 ◽  
Vol 194 (3) ◽  
pp. 929-939 ◽  
Author(s):  
Severin Zinöcker ◽  
Christine E. Schindler ◽  
Jeff Skinner ◽  
Tobias Rogosch ◽  
Michael Waisberg ◽  
...  

Retrovirology ◽  
2009 ◽  
Vol 6 (S1) ◽  
Author(s):  
Déborah Hirt ◽  
Christophe Bardin ◽  
Serge Diagbouga ◽  
Boubacar Nacro ◽  
Hervé Hien ◽  
...  

Bone ◽  
2015 ◽  
Vol 74 ◽  
pp. 166-170 ◽  
Author(s):  
V.S. Braithwaite ◽  
K.S. Jones ◽  
I. Schoenmakers ◽  
M. Silver ◽  
A. Prentice ◽  
...  

2012 ◽  
Vol 86 (20) ◽  
pp. 11024-11030 ◽  
Author(s):  
T. G. Phan ◽  
N. P. Vo ◽  
I. J. O. Bonkoungou ◽  
A. Kapoor ◽  
N. Barro ◽  
...  

2021 ◽  
Vol 6 ◽  
Author(s):  
Shanelle V. Clay ◽  
Cheria Jackson ◽  
Quincy Stephenson

Using a meta-synthesis approach, through the review of current literature, five published and peer reviewed qualitative research reports were studied. The intention was to identify interventions being used with West African children who have endured adverse childhood experiences. These results were found through matching inclusionary criteria and all studies were screened for appropriateness and relevance to the topic matter. The literature was analyzed across five online databases including Proquest, PsychInfo, Scopus, Wiley, and Springer from January 2005 to June 2020. The authors found minimal evidence indicating interventions used in West Africa for adverse experiences related specifically to children, but found themes related to interventions that serve West African families that include children. Findings were thematically analyzed through meta-synthesis and identified four themes used in the interventions, which include western, spiritual, expressive arts, and cultural approaches. West African children endure adverse experiences such as terrorism, abuse, and war violence that contribute to an increasing the need for mental health interventions. These experiences approached from western, spiritual, expressive arts, and cultural vantage points were identified but limited in information about delivery and efficacy, thus providing little guidance regarding further exploratory research.


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