scholarly journals West African Ebola Epidemic after One Year — Slowing but Not Yet under Control

2015 ◽  
Vol 372 (6) ◽  
pp. 584-587 ◽  
Author(s):  
Keyword(s):  
Author(s):  
Lucie Paloque ◽  
Romain Coppée ◽  
Barbara H. Stokes ◽  
Nina F. Gnädig ◽  
Karamoko Niaré ◽  
...  

Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum k13 ( pfk13 ) gene. Here, we carried out in vitro selection over a one-year period on a West African P. falciparum strain isolated from Kolle (Mali) under a dose-escalating artemisinin regimen. After 18 cycles of sequential drug pressure, the selected parasites exhibited enhanced survival to dihydroartemisinin in the ring-stage survival assay (RSA 0-3h = 9.2%). Sanger and whole-genome sequence analyses identified the PfK13 P413A mutation, localized in the BTB/POZ domain, upstream of the propeller domain. This mutation was sufficient to confer in vitro artemisinin resistance when introduced into the PfK13 coding sequence of the parasite strain Dd2 by CRISPR/Cas9 gene editing. These results together with structural studies of the protein demonstrate that the propeller domain is not the sole in vitro mediator of PfK13-mediated artemisinin resistance, and highlight the importance of monitoring for mutations throughout PfK13.


Retrovirology ◽  
2009 ◽  
Vol 6 (S1) ◽  
Author(s):  
Déborah Hirt ◽  
Christophe Bardin ◽  
Serge Diagbouga ◽  
Boubacar Nacro ◽  
Hervé Hien ◽  
...  

2005 ◽  
Vol 52 (9) ◽  
pp. 85-93 ◽  
Author(s):  
F. Rosillon ◽  
P. Vander Borght ◽  
H. Bado Sama

Inspired by the experience of a river contract in Wallonia (Belgium) since 1990, the implementation of a first river contract has been initiated in a West African country, Burkina Faso. This application is not limited to a simple transposition of the Walloon model. The Burkina context calls for adaptation to the local environmental and socio-economical realities with an adequate partnership management. The importance of the mobilization around this project of institutional partners, as well as local collectivities, agricultural producers and water users in general reveals the great expectations of the actors concerning this new tool of water participative management. But will the latter be equal to the task? A first assessment has been drawn up one year after the launch. During the first year of the project, a participative diagnostic was implemented but the understanding of basic notions of water management such as ‘river’ (not translatable in the local language), ‘watershed’, ‘contract’ were not obvious. After the identification of functions and uses of water in the basin, an environmental survey was started. This approach allows study with the river committees of the priority actions to be developed as a first project of restoration of the gallery forest alongside the stream to fight against desertification. This project of integrated and participative management of water at sub-basin level is a concrete example of solidarity and exchange know-how between North and South in the context of a sustainable development.


2015 ◽  
Vol 142 (694) ◽  
pp. 16-29 ◽  
Author(s):  
Allison B. Collow ◽  
Virendra P. Ghate ◽  
Mark A. Miller ◽  
Lynne C. Trabachino

2021 ◽  
Vol 15 ◽  
pp. 43-47
Author(s):  
J. U. AKPOKODJE ◽  
T. I. DEDE ◽  
P. I. ODILI

Semen collected from six mature West African Dwarf (WAD) rams by artificial Vagina, twice weekly for one year, early and late rainy season, and early and late dry season, showed no significant difference in volume of ejaculate and progressive motility of sperm. There was significant difference in sperm concentration, total sperm per ejaculate, total motile sperm per ejaculate and abnormal sperm. Seasonal changes in characteristics of the semen were associated with seasonal changes in temperature, indicating the detrimental effects of heat, even on indigenous stock.


2019 ◽  
Vol 19 (366) ◽  
Author(s):  

Political uncertainty has risen ahead of the 2020 presidential elections, after the ruling coalition between President Ouattara’s and former President Bédié’s parties ended in the summer of 2018. The authorities have requested a one-year program extension to provide an important stability anchor through 2020. The extension will help meet balance of payment needs, foster fiscal discipline, and sustain reforms, in turn helping support the West African Economic and Monetary Union’s external stability. Policies will center on preserving the program’s momentum, particularly adhering to the 3 percent of GDP budget deficit ceiling, preserving a moderate risk of debt distress and fostering private sector-led growth.


2021 ◽  
Vol 21 ◽  
pp. 25-28
Author(s):  
I. K. Odubote

Data on coat colour pigmentation and incidence of wattle were combined with production records of 1407 West African dwarf goats to study their influence on litter traits and body weight. There was no significant (P>0.05) difference among coat colours for litter size at birth and at weaning and birth weight. Basic white coloured goats were significantly (P <0.05) heavier at weaning and one year of age than the basic brown and black goats. The trend was that the weight decreased with increased pigmentation. Presence or absence of wattle did not exert any influence on the traits studied except yearling body weight Bilaterally wattled goats were lighter (P<0.01) than unilaterally wattled and non wattled goats.


2021 ◽  
Vol 27 (4) ◽  
pp. 548-571
Author(s):  
Michael J. Boivin ◽  
Roméo Zoumenou ◽  
Alla Sikorskii ◽  
Nadine Fievet ◽  
Jules Alao ◽  
...  

Itinerario ◽  
2000 ◽  
Vol 24 (2) ◽  
pp. 146-169 ◽  
Author(s):  
Michael Leroy Oberg

In August of 1587 Manteo, an Indian from Croatoan Island, joined a group of English settlers in an attack on the native village of Dasemunkepeuc, located on the coast of present-day North Carolina. These colonists, amongst whom Manteo lived, had landed on Roanoke Island less than a month before, dumped there by a pilot more interested in hunting Spanish prize ships than in carrying colonists to their intended place of settlement along the Chesapeake Bay. The colonists had hoped to re-establish peaceful relations with area natives, and for that reason they relied upon Manteo to act as an interpreter, broker, and intercultural diplomat. The legacy of Anglo-Indian bitterness remaining from Ralph Lane's military settlement, however, which had hastily abandoned the island one year before, was too great for Manteo to overcome. The settlers found themselves that summer in the midst of hostile Indians.


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