The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network Meta-analysis

Objective: To evaluate the effect of vitamin D supplementation (alone or with co-supplementation) on insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods: We performed a literature search of databases (Medline, Scopus, Web of Knowledge, Cochrane Library) and identified all reports of randomized controlled trials (RCTs) published prior to April 2018. We compared the effects of supplementation with vitamin D alone (dose from 1000 IU/d to 60,000 IU/week) or with co-supplements to the administration of placebos in women diagnosed with PCOS. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42018090572. Main results: Eleven of 345 identified studies were included in the analysis; these involved 601women diagnosed with PCOS. Vitamin D as a co-supplement was found to significantly decrease fasting glucose concentrations and the HOMA-IR value. HOMA-IR also declined significantly when vitamin D was supplemented with a dose lower than 4000 IU/d. Conclusions: Evidence from RCTs suggests that the supplementation of PCOS patients with continuous low doses of vitamin D (<4000 IU/d) or supplementation with vitamin D as a co-supplement may improve insulin sensitivity in terms of the fasting glucose concentration (supplementation with vitamin D in combination with other micronutrients) and HOMA-IR (supplementation with vitamin D in continuous low daily doses or as co-supplement).

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Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta-analysis

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.12793 ◽

2015 ◽

Vol 41 (11) ◽

pp. 1791-1802 ◽

Cited By ~ 12

Author(s):

Xin-Zhuan Jia ◽

Yong-Mei Wang ◽

Na Zhang ◽

Li-Na Guo ◽

Xiu-Li Zhen ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Biochemical Parameters ◽

Polycystic Ovary ◽

Meta Analysis ◽

Ovary Syndrome

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The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review

Hormone and Metabolic Research ◽

10.1055/a-1160-9902 ◽

2020 ◽

Vol 52 (07) ◽

pp. 485-491

Author(s):

Ashley Williams ◽

Jeganathan Ramesh Babu ◽

Danielle D. Wadsworth ◽

Donna Burnett ◽

Thangiah Geetha

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Experimental Studies ◽

Vitamin D Supplementation ◽

Total Serum ◽

Metabolic Profiles ◽

Ovary Syndrome ◽

Insulin Metabolism

AbstractThis systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. The inclusion criteria were women 18–45 years of age with polycystic ovary syndrome and comparing the metabolic or endocrine parameters between placebo and vitamin D supplementation groups. A total of ten studies were selected for this review. We found that vitamin D supplementation had a significant effect on insulin metabolism, total serum testosterone, hirsutism, C-reactive protein, and total antioxidant capacity in women with polycystic ovary syndrome. Evidence from available randomized controlled trials suggests that patients with polycystic ovary syndrome should take vitamin D supplementation for the beneficial effect of metabolic profiles. However, future research is needed regarding the beneficial effects in women who are non-obese with polycystic ovary syndrome, as well as more studies with larger sample sizes.

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The Effect of Vitamin D Supplementation on the Androgenic Profile in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials

Hormone and Metabolic Research ◽

10.1055/s-0043-103573 ◽

2017 ◽

Vol 49 (03) ◽

pp. 174-179 ◽

Cited By ~ 18

Author(s):

Maryam Azadi-Yazdi ◽

Azadeh Nadjarzadeh ◽

Hossein Khosravi-Boroujeni ◽

Amin Salehi-Abargouei

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Clinical Trials ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Ovary Syndrome

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The Effect of Vitamin D Supplementation on Blood Lipids in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials

International Journal of Endocrinology ◽

10.1155/2021/8849688 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Hong Gao ◽

YanTao Li ◽

WenNan Yan ◽

Fei Gao

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Cholesterol Level ◽

Blood Lipids ◽

Polycystic Ovary ◽

Meta Analysis ◽

Density Lipoprotein ◽

Vitamin D Supplementation ◽

Lipoprotein Cholesterol ◽

Ovary Syndrome

Purpose. Studies have found that vitamin D supplementation may improve blood lipids in patients with polycystic ovary syndrome, but the results are controversial, so this study will further analyze the effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome. Methods. PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases were searched up to May 2020, to identify randomized controlled trials of the effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome. The Cochrane risk of bias tool was applied to assess the risk of bias, and RevMan5.3 software was used for statistical analysis. Results. Ten studies were included in this study, including 543 subjects. The results of the meta-analysis showed that, compared with placebo, vitamin D supplementation can significantly reduce total cholesterol level (WMD = –11.32, 95% CI = [–14.51, –8.41], P < 0.00001 ), low-density lipoprotein cholesterol level (WMD = –4.83, 95% CI = [–7.52, –2.14], P = 0.0004 ), and triglyceride level (WMD = –8.23, 95% CI = [–13.08, –3.38], P = 0.0009 , but the effect on high-density lipoprotein cholesterol level is not statistically significant (WMD = –0.32, 95%CI = [–1.24, 0.60], P = 0.50 ). Conclusion. Vitamin D supplementation can significantly reduce total cholesterol, low-density lipoprotein cholesterol, and triglycerides in patients with polycystic ovary syndrome. However, it has no significant effect on high-density lipoprotein cholesterol.

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