A study of factors influencing urinary arsenic excretion in exposed workers

Abstract We studied chemical speciation of arsenic compounds in urine samples by using HPLC with inductively coupled plasma mass spectrometry detection. We examined urinary arsenic excretion patterns and the arsenic species excreted from nine human subjects who ingested seaweed products and crab (or shrimp). Fast urinary excretion of unchanged arsenobetaine was seen after ingestion of crab and shrimp, which contain arsenobetaine as the major arsenic species. In contrast, the arsenosugars, which comprise the major arsenic species in seaweed, are metabolized and have a longer retention time in the human body. When nine volunteers ingested the commercial seaweed product nori, both the urinary arsenic excretion pattern and the excreted arsenic species varied from individual to individual, and as many as six metabolites could be detected. It seems that arsenosugars are not decomposed by stomach acid and that reactions involving enzymatic and (or) microbial activity in the human body may be responsible for the metabolism of arsenosugars.

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Rate of Urinary Arsenic Excretion After Giving Acetarsone ("Stovarsol) and "Carbarsone" by Mouth.

Experimental Biology and Medicine ◽

10.3181/00379727-28-5201 ◽

1930 ◽

Vol 28 (2) ◽

pp. 145-148 ◽

Cited By ~ 2

Author(s):

M.-Y. Chen ◽

H. H. Anderson ◽

C. D. Leake

Keyword(s):

Urinary Arsenic ◽

Arsenic Excretion

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Measured versus modeled dietary arsenic and relation to urinary arsenic excretion and total exposure

Journal of Exposure Science & Environmental Epidemiology ◽

10.1038/jes.2012.120 ◽

2013 ◽

Vol 23 (4) ◽

pp. 442-449 ◽

Cited By ~ 21

Author(s):

Margaret Kurzius-Spencer ◽

Mary K O'Rourke ◽

Chiu-Hsieh Hsu ◽

Vern Hartz ◽

Robin B Harris ◽

...

Keyword(s):

Total Exposure ◽

Urinary Arsenic ◽

Dietary Arsenic ◽

Arsenic Excretion

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Effect of fasting on the pattern of urinary arsenic excretion

Journal of Environmental Monitoring ◽

10.1039/b613340a ◽

2007 ◽

Vol 9 (1) ◽

pp. 98-104 ◽

Cited By ~ 14

Author(s):

Eid I. Brima ◽

Richard O. Jenkins ◽

Paul R. Lythgoe ◽

Andrew G. Gault ◽

Dave A. Polya ◽

...

Keyword(s):

Urinary Arsenic ◽

Arsenic Excretion

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Factors influencing adhesive bonding at the bone/implant interface

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100130201 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1114-1115

Author(s):

Julie A. Martini ◽

Robert H. Doremus

Keyword(s):

Electron Microscopy ◽

Adhesive Bonding ◽

Microscopy Study ◽

Electron Microscopy Study ◽

Bone Implant ◽

Factors Influencing ◽

Lr White ◽

Transmission Electron ◽

New Zealand White Rabbits ◽

Scanning Electron

Tracy and Doremus have demonstrated chemical bonding between bone and hydroxylapatite with transmission electron microscopy. Now researchers ponder how to improve upon this bond in turn improving the life expectancy and biocompatibility of implantable orthopedic devices.This report focuses on a study of the- chemical influences on the interfacial integrity and strength. Pure hydroxylapatite (HAP), magnesium doped HAP, strontium doped HAP, bioglass and medical grade titanium cylinders were implanted into the tibial cortices of New Zealand white rabbits. After 12 weeks, the implants were retrieved for a scanning electron microscopy study coupled with energy dispersive spectroscopy.Following sacrifice and careful retrieval, the samples were dehydrated through a graduated series starting with 50% ethanol and continuing through 60, 70, 80, 90, 95, and 100% ethanol over a period of two days. The samples were embedded in LR White. Again a graduated series was used with solutions of 50, 75 and 100% LR White diluted in ethanol.

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