Nephrotoxic Nephritis and Glomerulonephritis: Animal Model Versus Human Disease

AbstractThe aim of the study was to compare the classical animal model (based on total milk for 305 days) with the Test-Day model (using monthly records of milk yield from Official Records of Performances). The data set derived from a total 175 animals (cows with records, parents of these animals and the descendants) from two Romanian breeds (Romanian Black Spotted and Montbeliarde), the phenotypic and the pedigree information arisen from National Research Development Institute for Animal Biology and Nutrition (IBNA-Balotesti). The selection criteria to be included in the analysis for each cow was to have at least 3 test-days and the days in milk between 200 and 330 for the Test-Day model and the total amount of the 305- day lactation yield for classical Animal Model respectively. Both models use B.L.U.P methodology and for that reason all the estimates were adjusted for fixed effects and all the breeding values and the solution for fixed effects were estimated simultaneous. For the animal model the fixed effects used was the breed and the year of performing and for the Test-Day model was an extra one, the test day effect. The correlation calculated between test days was very high (over 90%) for consecutive tests, and was getting lower when the days between tests was higher (under 40%). Also, in terms of heritability the values were in normal limits throughout lactation, except at the beginning and end of lactation period where these values were a little bit higher. The comparison of the ranking of breeding values with Spearman rank correlation shows that in 80% of the cases the ranking was similar for both models. As the ranking correlations shows, it is certain that the two models are very similar when they are used for genetic evaluation. But, in conclusion, we can say that for a better lactation curve estimation it is recommending to use test-day model for dairy cattle.

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A novel stop codon mutation (X417L) of the ferrochelatase gene in bovine protoporphyria, a natural animal model of the human disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/s0925-4439(98)00052-0 ◽

1998 ◽

Vol 1408 (1) ◽

pp. 18-24 ◽

Cited By ~ 11

Author(s):

Mary M. Jenkins ◽

Robert D. LeBoeuf ◽

George R. Ruth ◽

Joseph R. Bloomer

Keyword(s):

Animal Model ◽

Human Disease ◽

Stop Codon ◽

Stop Codon Mutation ◽

Codon Mutation

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Unilateral Entorhinal Cortex Lesion - An Animal Model For Cognitive Impairment in Human Disease: Effects on Adenosine Receptors and Second Messengers

Nucleosides and Nucleotides ◽

10.1080/07328319108047265 ◽

1991 ◽

Vol 10 (5) ◽

pp. 1175-1176 ◽

Cited By ~ 2

Author(s):

J. Deckert ◽

M. B. Jorgensen

Keyword(s):

Animal Model ◽

Cognitive Impairment ◽

Entorhinal Cortex ◽

Adenosine Receptors ◽

Human Disease ◽

Second Messengers ◽

Cortex Lesion ◽

Entorhinal Cortex Lesion

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Sire evaluation using animal model versus differentconventional methods in red sindhi cattle

Indian Journal of Animal Research ◽

10.18805/ijar.v0i0f.3805 ◽

2016 ◽

Author(s):

P. K. Mallick ◽

A. K. Ghosh ◽

A. S. Rajendiran

Keyword(s):

Animal Model ◽

Genetic Gain ◽

Simplex Method ◽

Animal Husbandry ◽

Breeding Value ◽

Sire Evaluation ◽

Improvement Programme ◽

Breed Improvement ◽

Model Versus ◽

Selection Of

The effectiveness of sire evaluation is the backbone of any breed improvement programme as much as 61% of genetic gain in dairy cattle results from selection of sires through “bulls to breed cows” and “bulls to breed bulls” path. The application of latest and simplex method of sire evaluation like BLUPF90 in Indian breeds is scanty. The present investigation was planned to evaluate the Red Sindhi sires by this method and to compare the effectiveness of BLUPF90 method with other conventional methods of sire evaluation in Red Sindhi cattle. The records of production and reproduction performances of first lactation traits of 717 Red Sindhi cows, progeny of 58 sires, spread over a period of 40 years (1966-2005) from CCBF, Chiplima, Orissa under the control of Department of Animal Husbandry, Dairying and Fisheries, Ministry of Agriculture, Government of India and CBF, Kalsi, Deheradun, Uttarakhand were analyzed. The present study was single and multi-trait evaluation of breeding values of Red Sindhi sires. The overall least squares population mean for first lactation milk yield (FLMY) was 1536.35±54.87 kg. The average breeding value of sires of single trait from different methods ranged from 1536.35 kg (LSM, DFREML and BLUPF90-Dairy Pack) to 1588.50 kg (simple daughter average) but in multi-trait method the breeding value does not vary with each other. The comparison of different method of sire evaluation based on single trait for FLMY only shows that the DFREML model for single trait should be preferred over the BLUP, LSM and simple daughter average methods for evaluating the sire breeding value. However, if a sire-breeding value is to be computed from multi traits then BLUPF90 model may be preferred over DFREML model.

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