Chemical Composition, Antimicrobial and Topical Anti-inflammatory Activity ofValeriana jatamansiJones. Essential Oil

2011 ◽  
Vol 14 (4) ◽  
pp. 417-422 ◽  
Author(s):  
Supriya Agnihotri ◽  
Sharad Wakode ◽  
M. Ali
2016 ◽  
Vol 19 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Ji-Young Kang ◽  
Byung-Soo Chun ◽  
Min-Chul Lee ◽  
Jae-Suk Choi ◽  
In Soon Choi ◽  
...  

2021 ◽  
Vol 275 ◽  
pp. 114136
Author(s):  
Raul Cremonezi Piva ◽  
Maria Helena Verdan ◽  
Lidiane Schultz Branquinho ◽  
Cândida Aparecida Leite Kassuya ◽  
Claudia Andrea Lima Cardoso

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1619
Author(s):  
Jae-Hoon Lee ◽  
Yun-Yeol Lee ◽  
Jangho Lee ◽  
Young-Jin Jang ◽  
Hae-Won Jang

Schisandra chinensis (Turcz.) Baill., which is known as omija in South Korea, is mainly cultivated in East Asia. The present study aimed to investigate the chemical composition of essential oil from the omija (OMEO) fruit obtained by supercritical fluid extraction using CO2 and to confirm the antioxidant and anti-inflammatory activity of OMEO using HaCaT human keratinocyte and RAW 264.7 murine macrophages. As a result of the chemical composition analysis of OMEO using gas chromatography-mass spectrometry, a total of 41 compounds were identified. The detailed analysis results are sesquiterpenoids (16), monoterpenoids (14), ketones (4), alcohols (3), aldehydes (2), acids (1), and aromatic hydrocarbons (1). OMEO significantly reduced the increased ROS levels in HaCaT keratinocytes induced by UV-B irradiation (p < 0.05). It was confirmed that 5 compounds (α-pinene, camphene, β-myrcene, 2-nonanone, and nerolidol) present in OMEO exhibited inhibitory activity on ROS production. Furthermore, OMEO showed excellent anti-inflammatory activity in RAW 264.7 macrophages induced by lipopolysaccharide. OMEO effectively inhibited NO production (p < 0.05) by suppressing the expression of the iNOS protein. Finally, OMEO was investigated for exhibition of anti-inflammatory activity by inhibiting the activation of NF-κB pathway. Taken together, OMEO could be used as a functional food ingredient with excellent antioxidant and anti-inflammatory activity.


Author(s):  
Lina Karrat ◽  
Ream Nayal ◽  
Mohammad Yaser Abajy

This investigation aims to determine the chemical composition of Pinus brutia leaves essential oil and evaluate its anti-inflammatory property using Human Red Blood Cells (HRBC) membrane stabilization assay and Albumin denaturation assay. The chemical composition of essential oil (EO) obtained by hydro-distillation of leaves of Pinus brutia was investigated by GC-MS. The anti-inflammatory effect of EO was evaluated using Human Red Blood Cells (HRBC) membrane stabilization assay and Albumin denaturation assay. The main constituents of EO were α-Terpineol (66.16%), 3-Carene (4.90%), Carveol (4.55%) and cis-Verbenol (3.22%). The inhibion of hemolysis was observed at concentrations (2.5-12.5) µg/ml. Moreover, albumin denaturation test showed protection effect at concentrations (8-40) µg/ml. We concluded that, Pinusbrutia EO shows strong anti-inflammatory activity at different concentration when compared to standard drug of Diclofenac sodium. In addition, GC-MS analysis of Pinus brutia EO showed the presence of α-Terpineol as major compound in the oil. It reveals that this constituent is responsible to maximum protection of albumin denaturation and membrane stabilization assay. The future work will be determination of anti-inflammatory by in vivo models.


2019 ◽  
Vol 12 (8) ◽  
pp. 3236-3243 ◽  
Author(s):  
Vanessa Rodrigues ◽  
Célia Cabral ◽  
Leisa Évora ◽  
Isabel Ferreira ◽  
Carlos Cavaleiro ◽  
...  

2017 ◽  
Vol 12 (4) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Wafae Abdelli ◽  
Fouad Bahri ◽  
Abderrahmane Romane ◽  
Martina Höferl ◽  
Juergen Wanner ◽  
...  

This work aims to elucidate the chemical composition of two essential oil (EO) samples obtained from the leaves of Thymus vulgaris L. ( Lamiaceae) collected in two regions of Northwestern Algeria (Tlemcen and Mostaganem) and to assess their in vivo acute toxicity and anti-inflammatory activity. Sixty-six compounds could be identified by means of simultaneous GC-FID and GC-MS, accounting for 99.3% of total thyme oil of Mostaganem (EO.TM) and 99.0% of Tlemcen (EO.TT). In both samples, thymol was the major component, amounting to 59.5% (EO.TM) and 67.3% (EO.TT) of the total oil. EO.TT proved to be acutely toxic to mice at a dose of 4500 mg/kg p.o., whereas EO.TM did not show signs of acute toxicity, even at the highest dose tested (5000 mg/kg p.o.). Both EO samples were proven to possess anti-inflammatory activities, significantly reducing carrageenan-induced paw edema in mice (after 6 hours at a dose of 400 mg/kg p.o) at 58.4% for EO.TT and 50.4% for EO.TM, respectively. In conclusion, it could be demonstrated that EOs of T. vulgaris exhibit a considerable in vivo anti-inflammatory activity at non-toxic doses.


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