Significance of Diagnostic Parameters in [13C]Octanoic Acid Gastric Emptying Breath Tests*

Abstract Suitability of isotope-selective nondispersive infrared spectrometry (IRIS) for evaluation of [13C]octanoic acid gastric-emptying breath test was assessed and compared with standard isotope ratio–mass spectrometry (IRMS). The estimated bias of IRMS and IRIS measurements of baseline-corrected 13CO2exhalation amounted to ± 0.1 and ± 0.6 Δδ values (n = 360), respectively. In breath tests performed on 60 diabetic patients, the gastric emptying parameters were calculated by nonlinear regression analysis of the time course of 13CO2exhalation: half-emptying time (t1/2,breath, 90 ± 39 min), lag phase (tlag,breath, 34 ± 27 min), and gastric emptying coefficient (GEC, 2.9 ± 0.5). A reasonable linear correlation was found between the two methods (y = IRIS, x = IRMS) with respect to Δδ values (y = 0.35 + 0.92x, r = 0.985, Sy|x = ±0.6, n = 1116) and a rather good agreement of the computed gastric emptying parameters was obtained (t1/2,breath: y = 0.99x + 4.06, Sy|x = ±6.3; tlag,breath: y = 0.97x + 0.96, Sy|x = ±3.4; GEC: y = 0.97x − 0.01, Sy|x = ±0.09).

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Gastric Emptying of Solids and Semi-solids in Morbidly Obese and Non-obese Subjects: An Assessment Using the 13C-Octanoic Acid and 13C-Acetic Acid Breath Tests

Obesity Surgery ◽

10.1007/s11695-007-9031-4 ◽

2007 ◽

Vol 17 (2) ◽

pp. 236-241 ◽

Cited By ~ 49

Author(s):

Aloísio Cardoso-Júnior ◽

Luiz Gonzaga Vaz Coelho ◽

Paulo Roberto Savassi-Rocha ◽

Maria Cristina Vignolo ◽

Marcelo Militão Abrantes ◽

...

Keyword(s):

Acetic Acid ◽

Gastric Emptying ◽

Octanoic Acid ◽

Morbidly Obese ◽

Breath Tests ◽

Obese Subjects

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Comparison of the gastric emptying results among the 13C-octanoic acid breath tests, scintigraphy, and acetaminophen method

Journal of smooth muscle research Japanese section ◽

10.1540/heikatsukinzashi1997.6.j107 ◽

2002 ◽

Vol 6 (3) ◽

pp. J107-J113

Author(s):

Daisuke SHIRASAKA ◽

Masaaki KACHI ◽

Nobuo AOYAMA

Keyword(s):

Gastric Emptying ◽

Octanoic Acid ◽

Breath Tests

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Is there a role for breath tests in the diagnosis and management of delayed gastric emptying?

Minerva Gastroenterologica e Dietologica ◽

10.23736/s1121-421x.19.02557-1 ◽

2019 ◽

Vol 65 (2) ◽

Author(s):

Carlo Sguazzini

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Breath Tests ◽

Diagnosis And Management

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Some pearl millet-based foods promote satiety or reduce glycaemic response in a crossover trial

British Journal Of Nutrition ◽

10.1017/s0007114520005036 ◽

2020 ◽

pp. 1-31

Author(s):

Anna M.R. Hayes ◽

Fanny Gozzi ◽

Aminata Diatta ◽

Tom Gorissen ◽

Clay Swackhamer ◽

...

Keyword(s):

Gastric Emptying ◽

Pearl Millet ◽

Octanoic Acid ◽

Crossover Trial ◽

Normal Weight ◽

Glycaemic Response ◽

Continuous Glucose Monitor ◽

Gastric Emptying Rate ◽

White Rice ◽

Traditionally Prepared

Abstract In a previous trial in Mali, we showed traditional pearl millet couscous and thick porridge delayed gastric emptying (~5 h half-emptying times) in a normal weight population compared to non-traditional carbohydrate-based foods (pasta, potatoes, white rice; ~3 h half-emptying times), and in a gastric simulator we showed millet couscous had slower digestion than wheat couscous. In light of these findings, we tested the hypothesis in a normal weight U.S. population (n=14) that millet foods would reduce glycaemic response (continuous glucose monitor), improve appetitive sensations (Visual Analog Scale ratings), as well as reduce gastric emptying rate (13C octanoic acid breath test). Five carbohydrate-based foods (millet couscous – commercial and self-made, millet thick porridge, wheat couscous, white rice) were fed in a crossover trial matched on available carbohydrate basis. Significantly lower overall glycaemic response was observed for all millet-based foods and wheat couscous compared to white rice (p≤0.05). Millet couscous (self-made) had significantly higher glycaemic response than millet couscous (commercial) and wheat couscous (p<0.0001), but as there were no differences in peak glucose values (p>0.05) an extended glycaemic response was indicated for self-made couscous. Millet couscous (self-made) had significantly lower hunger ratings (p<0.05) and higher fullness ratings (p<0.01) than white rice, millet thick porridge, and millet couscous (commercial). A normal gastric emptying rate (<3 h half-emptying times) was observed for all foods, with no significant differences among them (p>0.05). In conclusion, some traditionally prepared pearl millet foods show the potential to reduce glycaemic response and promote satiety.

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