Three-dimensional culturing of the Hodgkin lymphoma cell-line L1236 induces a HL tissue-like gene expression pattern

2007 ◽  
Vol 48 (10) ◽  
pp. 2042-2053 ◽  
Author(s):  
Anna Birgersdotter ◽  
Karl R. N. Baumforth ◽  
Anna Porwit ◽  
Anne Sundblad ◽  
Kerstin I. Falk ◽  
...  
Leukemia ◽  
2009 ◽  
Vol 23 (10) ◽  
pp. 1885-1893 ◽  
Author(s):  
D Baus ◽  
F Nonnenmacher ◽  
S Jankowski ◽  
C Döring ◽  
C Bräutigam ◽  
...  

2012 ◽  
Vol 318 (3) ◽  
pp. 169-176 ◽  
Author(s):  
Cheng Liu ◽  
Frida Schain ◽  
Hongya Han ◽  
Dawei Xu ◽  
Hillevi Andersson-Sand ◽  
...  

Leukemia ◽  
2013 ◽  
Vol 27 (8) ◽  
pp. 1677-1687 ◽  
Author(s):  
S L Locatelli ◽  
A Giacomini ◽  
A Guidetti ◽  
L Cleris ◽  
R Mortarini ◽  
...  

Leukemia ◽  
2014 ◽  
Vol 28 (9) ◽  
pp. 1861-1871 ◽  
Author(s):  
S L Locatelli ◽  
L Cleris ◽  
G G Stirparo ◽  
S Tartari ◽  
E Saba ◽  
...  

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Christine Kleinert ◽  
Matthieu Blanchet ◽  
François Gagné ◽  
Michel Fournier

The determination of changes in gene expression profiles with xenobiotic dose will allow identifying biomarkers and modes of toxicant action. The harbor seal (Phoca vitulina) 11B7501 B lymphoma cell line was exposed to 1, 10, 100, 1000, 10,000, or 25,000 μg/L 17α-ethinyl estradiol (EE2, the active compound of the contraceptive pill) for 24 h. Following exposure, RNA was extracted and transformed into cDNA. Transcript expression in exposed vs. control lymphocytes was analyzed via RT-qPCR to identify genes with altered expression. Our analysis indicates that gene expression for all but the reference gene varied with dose, suggesting that different doses induce distinct physiological responses. These findings demonstrate that RT-qPCR could be used to identify immunotoxicity and relative dose in harbor seal leukocytes.


2016 ◽  
Vol 35 (4) ◽  
pp. 567-575 ◽  
Author(s):  
Masahiko Hayashida ◽  
Masanori Daibata ◽  
Erika Tagami ◽  
Takahiro Taguchi ◽  
Fumiyo Maekawa ◽  
...  

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