Determination of Total N-Nitroso Compounds in Biological Fluids By Photolytic Denitrosation and Thermal Energy Analysis

1993 ◽  
Vol 21 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
George M. Janini ◽  
Stephen D. Fox ◽  
Michael L. Citro ◽  
Gary M. Muschik ◽  
Haleem J. Issaq
Keyword(s):  
Thermal Energy ◽  
Energy Analysis ◽  
Biological Fluids ◽  
Nitroso Compounds ◽  
Total N

Improved group determination of total N-nitroso compounds in human gastric juice by chemical denitrosation and thermal energy analysis

The Analyst ◽  
1987 ◽  
Vol 112 (7) ◽  
pp. 945 ◽  
Author(s):  
Brigitte Pignatelli ◽  
Isabelle Richard ◽  
Marie Christine Bourgade ◽  
Helmut Bartsch
Keyword(s):  
Gastric Juice ◽  
Thermal Energy ◽  
Energy Analysis ◽  
Nitroso Compounds ◽  
Total N ◽  
Human Gastric Juice

Determination of Extractable, Apparent Total N-Nitroso Compounds in Cured-Meat Products

1995 ◽  
Vol 78 (6) ◽  
pp. 1435-1439
Author(s):  
Walter Fiddler ◽  
John W Pensabene ◽  
Robert C Doerr ◽  
Robert A Gates
Keyword(s):  
Energy Analysis ◽  
Meat Products ◽  
Nitroso Compounds ◽  
Chemiluminescence Detection ◽  
Minimum Level ◽  
Reliable Measurement ◽  
Total N ◽  
Three Samples ◽  
Cured Meat

Abstract The modification of a newly developed method for determination of apparent total N-nitroso compounds by chemical denitrosation and chemiluminescence detection of nitric oxide (thermal energy analysis) is described. The minimum level of reliable measurement was 0.1 ppm, and the repeatability of the method was 0.2 ppm, based on the response of N-nitrosoproline (NPro). Seventy-three samples of cured-meat products, including frankfurters, bacon, and ham, were examined; 50 samples contained less than 1 ppm. The largest amounts, up to 24.8 ppm, were detected in canned corned beef. This method has several advantages over other methods.

Description of the thermal energy analyzer (TEA) for trace determination of volatile and nonvolatile N-nitroso compounds

1975 ◽  
Vol 47 (7) ◽  
pp. 1188-1191 ◽  
Author(s):  
David H. Fine ◽  
Firooz. Rufeh ◽  
David. Lieb ◽  
David P. Rounbehler
Keyword(s):  
Thermal Energy ◽  
Nitroso Compounds ◽  
Trace Determination ◽  
Energy Analyzer

Gas Chromatographic-Thermal Energy Analysis Method for Determination of Volatile N-Nitrosamines in Baby Bottle Rubber Nipples: Collaborative Study

1987 ◽  
Vol 70 (1) ◽  
pp. 64-68 ◽  
Author(s):  
J Ian Gray ◽  
Michael A Stachiw
Keyword(s):  
Thermal Energy ◽  
Energy Analysis ◽  
Collaborative Study ◽  
Internal Standard ◽  
Analytical Techniques ◽  
The United States ◽  
Baby Bottle ◽  
Relative Standard ◽  
Better Than

Abstract A collaborative study was conducted on the U.S. Food and Drug Administration (FDA) dichloromethane extraction method for determining volatile N-nitrosamines in baby bottle rubber nipples. Following dichloromethane extraction, A'-nitrosamines were determined by gas chromatography-thermal energy analysis. Six pairs of blind duplicate rubber nipple samples representing 6 lots were analyzed by 11 collaborating laboratories. All samples were portions taken from equilibrated composites of cut-up rubber nipples obtained from manufacturers in the United States. Recoveries of the internal standard (N-nitrosodipropylamine) at approximately 20 ppb ranged from 10 to 120%. Reproducibility relative standard deviations (RSDJ were between 35 and 45% for N-nitrosamine levels from 10 to 20 ppb. However, when data from laboratories with recoveries less than 75% were excluded (this is now specified in the method), RSD„ values were between 11 and 32% for N-nitrosamine levels from 6 to 26 ppb. Values were consistent with or better than those reported for other analytical techniques designed to quantitate trace contaminants at the low ppb level, e.g., afiatoxin in foods. The method has been adopted official first action for the quantitation of volatile N-nitrosamines in baby bottle rubber nipples.

Group-selective determination of total N-nitroso compounds in nitrate-containing human urine samples

The Analyst ◽  
1989 ◽  
Vol 114 (9) ◽  
pp. 1103 ◽  
Author(s):  
Brigitte Pignatelli ◽  
Chong-Sheng Chen ◽  
Pascal Thuillier ◽  
Helmut Bartsch
Keyword(s):  
Human Urine ◽  
Urine Samples ◽  
Nitroso Compounds ◽  
Total N ◽  
Selective Determination ◽  
Human Urine Samples
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