Selective histone deacetylase small molecule inhibitors: recent progress and perspectives

2016 ◽  
Vol 27 (5) ◽  
pp. 621-636 ◽  
Author(s):  
Hai-Tao Qin ◽  
Huan-Qiu Li ◽  
Feng Liu
Keyword(s):  
Histone Deacetylase ◽  
Small Molecule ◽  
Recent Progress ◽  
Small Molecule Inhibitors

Recent progress in small-molecule inhibitors for critical therapeutic targets of necroptosis

2021 ◽  
Author(s):  
Zhennan Fang ◽  
Huiqiang Wei ◽  
Wenfeng Gou ◽  
Leyuan Chen ◽  
Changfen Bi ◽  
...  
Keyword(s):  
Cell Death ◽  
Small Molecule ◽  
Future Development ◽  
Recent Progress ◽  
Small Molecule Inhibitors ◽  
Cell Necrosis ◽  
Significant Progress ◽  
Regulated Cell Death ◽  
Associated Proteins ◽  
Widespread Interest

Nonapoptotic types of regulated cell death have attracted widespread interest since the discovery that certain forms of cell necrosis can be regulated. In particular, research into cell necroptosis has made significant progress in connection with kidney, inflammatory, degenerative and neoplastic diseases. Inhibitors targeting the critical necroptosis-associated proteins RIPK1/3 and MLKL have been in development for more than a decade. Herein the authors compile a list of the known small-molecule inhibitors of these enzymes and representative structures of compounds co-crystallized with these proteins and put forward some thoughts regarding their future development.

scholarly journals PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

2014 ◽  
Vol 5 (10) ◽  
pp. 1055-1062 ◽  
Author(s):  
F. A. Schroeder ◽  
C. Wang ◽  
G. C. Van de Bittner ◽  
R. Neelamegam ◽  
W. R. Takakura ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Small Molecule ◽  
Pet Imaging ◽  
Small Molecule Inhibitors ◽  
Target Engagement

Design and synthesis of imidazole based zinc binding groups as novel small molecule inhibitors targeting Histone deacetylase enzymes in lung cancer

2020 ◽  
Vol 1214 ◽  
pp. 128177 ◽  
Author(s):  
Saravanan Kandasamy ◽  
Prabhu Subramani ◽  
Kannupal Srinivasan ◽  
John marshal Jayaraj ◽  
Gunasekaran Prasanth ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Histone Deacetylase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Zinc Binding ◽  
Design And Synthesis

Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases

2006 ◽  
Vol 6 (6) ◽  
pp. 711-717 ◽  
Author(s):  
Alex Kiselyov ◽  
Konstantin Balakin ◽  
Sergey Tkachenko ◽  
Nikolay Savchuk
Keyword(s):  
Protein Kinases ◽  
Small Molecule ◽  
Recent Progress ◽  
Small Molecule Inhibitors
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