Recent Progress in the Discovery and Clinical Application of Small-Molecule Inhibitors EZH2 and EED

2020 ◽  
pp. 319-343
Author(s):  
Julian R. Levell
Keyword(s):  
Clinical Application ◽  
Small Molecule ◽  
Recent Progress ◽  
Small Molecule Inhibitors

Recent progress in small-molecule inhibitors for critical therapeutic targets of necroptosis

2021 ◽  
Author(s):  
Zhennan Fang ◽  
Huiqiang Wei ◽  
Wenfeng Gou ◽  
Leyuan Chen ◽  
Changfen Bi ◽  
...  
Keyword(s):  
Cell Death ◽  
Small Molecule ◽  
Future Development ◽  
Recent Progress ◽  
Small Molecule Inhibitors ◽  
Cell Necrosis ◽  
Significant Progress ◽  
Regulated Cell Death ◽  
Associated Proteins ◽  
Widespread Interest

Nonapoptotic types of regulated cell death have attracted widespread interest since the discovery that certain forms of cell necrosis can be regulated. In particular, research into cell necroptosis has made significant progress in connection with kidney, inflammatory, degenerative and neoplastic diseases. Inhibitors targeting the critical necroptosis-associated proteins RIPK1/3 and MLKL have been in development for more than a decade. Herein the authors compile a list of the known small-molecule inhibitors of these enzymes and representative structures of compounds co-crystallized with these proteins and put forward some thoughts regarding their future development.

Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases

2006 ◽  
Vol 6 (6) ◽  
pp. 711-717 ◽  
Author(s):  
Alex Kiselyov ◽  
Konstantin Balakin ◽  
Sergey Tkachenko ◽  
Nikolay Savchuk
Keyword(s):  
Protein Kinases ◽  
Small Molecule ◽  
Recent Progress ◽  
Small Molecule Inhibitors
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