Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

2017 ◽  
Vol 60 (19) ◽  
pp. 7965-7983 ◽  
Author(s):  
Guoqiang Dong ◽  
Wei Chen ◽  
Xia Wang ◽  
Xinglin Yang ◽  
Tianying Xu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Small Molecule ◽  
Cancer Metabolism ◽  
Small Molecule Inhibitors ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Dual Inhibitors

scholarly journals PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

2014 ◽  
Vol 5 (10) ◽  
pp. 1055-1062 ◽  
Author(s):  
F. A. Schroeder ◽  
C. Wang ◽  
G. C. Van de Bittner ◽  
R. Neelamegam ◽  
W. R. Takakura ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Small Molecule ◽  
Pet Imaging ◽  
Small Molecule Inhibitors ◽  
Target Engagement

Design and synthesis of imidazole based zinc binding groups as novel small molecule inhibitors targeting Histone deacetylase enzymes in lung cancer

2020 ◽  
Vol 1214 ◽  
pp. 128177 ◽  
Author(s):  
Saravanan Kandasamy ◽  
Prabhu Subramani ◽  
Kannupal Srinivasan ◽  
John marshal Jayaraj ◽  
Gunasekaran Prasanth ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Histone Deacetylase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Zinc Binding ◽  
Design And Synthesis

scholarly journals Patents targeting the Warburg effect for cancer therapy: an interview with William P Katt

2020 ◽  
Vol 9 (1) ◽  
pp. 1-2
Author(s):  
William P Katt
Keyword(s):  
Small Molecule ◽  
Cancer Metabolism ◽  
Small Molecule Inhibitors ◽  
Rensselaer Polytechnic Institute ◽  
Yale University ◽  
Graduate Studies ◽  
Cancer Society ◽  
Cornell University ◽  
Research Associate ◽  
Rho Gef

Dr William Katt is a multidisciplinary scientist with particular focus in computational, synthetic and biological chemistry. He obtained his undergraduate degree at Rensselaer Polytechnic Institute and performed his graduate studies at Yale University, where he focused on designing small-molecule inhibitors of the Rho/Rho GEF interaction. Following those studies, Dr Katt accepted a fellowship from the American Cancer Society which funded his work at Cornell University, where he investigated small-molecule inhibitors of the enzyme glutaminase, a key player in cancer metabolism. Today, Dr Katt is a research associate at Cornell and maintains a number of collaborations with researchers across the nation examining glutaminase, cancer stem cells, nano-therapeutics and more, with the goal of developing therapeutic approaches that will eventually help patients in the clinic.

scholarly journals Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase fromPlasmodium falciparum

2009 ◽  
Vol 52 (8) ◽  
pp. 2185-2187 ◽  
Author(s):  
Vishal Patel ◽  
Ralph Mazitschek ◽  
Bradley Coleman ◽  
Cokey Nguyen ◽  
Sameer Urgaonkar ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Class I ◽  
Identification And Characterization

scholarly journals Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Tian-Ying Xu ◽  
Sai-Long Zhang ◽  
Guo-Qiang Dong ◽  
Xin-Zhu Liu ◽  
Xia Wang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Nicotinamide Phosphoribosyltransferase
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