:
The synthesis of ester containing heterocyclic compounds via multicomponent reaction is one of the most preferable
process in the synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range
of biological application in the pharmaceutical field. Therefore, many method have been developed for the synthesis of these
type of derivatives. However, some of them are carried out in the presence of toxic solvents and catalysts, with lower yields,
longer reaction times, low selectivities and by-products. Thus, the development of new synthetic methods for the ester
synthesis is required in the medicinal chemistry. As we know, multicomponent reactions (MCRs) are a powerful tool towards
the one-pot ester synthesis, so in this article we have reviewed the recent developments in ester synthesis. This work covers
selected explanation of methods via multicomponent reactions to explore the methodological development in ester synthesis.
Multicomponent reactions in drug discovery and medicinal chemistry