The role of sulfamide derivatives in medicinal chemistry: a patent review (2006 – 2008)

3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed, focusing on aspects related to its natural origin, synthetic procedures and pharmacological applications. This review paper is based on the most relevant literature related to the role of 3-phenylcoumarins in the design of new drug candidates. The references presented in this review have been collected from multiple electronic databases, including SciFinder, Pubmed and Mendeley.

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Towards Academic Drug Development Guidelines

10.26434/chemrxiv.8869574 ◽

2019 ◽

Author(s):

Christopher Southan

Keyword(s):

Drug Development ◽

Success Rate ◽

Case Studies ◽

Small Molecule ◽

Research Productivity ◽

Medicinal Chemistry ◽

Academic Development ◽

Commercial Development ◽

Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

Download Full-text

Towards Academic Drug Development Guidelines

10.26434/chemrxiv.8869574.v1 ◽

2019 ◽

Author(s):

Christopher Southan

Keyword(s):

Drug Development ◽

Success Rate ◽

Case Studies ◽

Small Molecule ◽

Research Productivity ◽

Medicinal Chemistry ◽

Academic Development ◽

Commercial Development ◽

Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

Download Full-text