Genetic polymorphisms of alcohol-metabolizing enzymes and their association with alcoholism risk, personality and anthropometric traits among Malaysian university students

2017 ◽  
Vol 23 (2) ◽  
pp. 160-170 ◽  
Author(s):  
Hing-Huat Ong ◽  
Foong-Vai Khor ◽  
Kausalyah Balasupramaniam ◽  
Yee-How Say
Keyword(s):  
University Students ◽  
Genetic Polymorphisms ◽  
Metabolizing Enzymes ◽  
Alcoholism Risk

Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics

2011 ◽  
Vol 68 (5) ◽  
pp. 645-655 ◽  
Author(s):  
Meghan Brennan ◽  
J. Andrew Williams ◽  
Ying Chen ◽  
Michael Tortorici ◽  
Yazdi Pithavala ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population

2007 ◽  
Vol 21 (4) ◽  
pp. 419-426 ◽  
Author(s):  
Kostas Arvanitidis ◽  
Georgia Ragia ◽  
Maria Iordanidou ◽  
Sofia Kyriaki ◽  
Athanasia Xanthi ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Greek Population ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes

2010 ◽  
Vol 30 (4) ◽  
pp. 338-342 ◽  
Author(s):  
Yong-Dae Kim ◽  
Sang-Yong Eom ◽  
Yan Wei Zhang ◽  
Hyeongsu Kim ◽  
Jung-Duk Park ◽  
...  
Keyword(s):  
Dna Damage ◽  
Occupational Exposure ◽  
Genetic Polymorphisms ◽  
Hippuric Acid ◽  
Oxidative Dna Damage ◽  
Statistical Significance ◽  
Biological Marker ◽  
Metabolizing Enzymes ◽  
Toluene Exposure ◽  
The Relationship

Urinary hippuric acid (HA) has been widely used as a biological marker of occupational exposure to toluene, although it is no longer valid for low levels of toluene exposure. Toluene exposure is known to induce oxidative DNA damage and the metabolism is affected by genetic polymorphisms of some metabolizing enzymes. Therefore, genetic polymorphisms of these metabolizing enzymes must be considered in the evaluation of oxidative stress caused by toluene exposure. We evaluated the relationship between urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and urinary HA in individuals without occupational exposure to toluene and characterized the possible roles of GSTM1, GSTT1, and aldehyde dehydrogenase 2 (ALDH2) genotypes in the relationships between these markers. In this study, we enrolled 92 healthy Koreans. Urinary HA and 8-OHdG levels were measured and the correlations between them were statistically tested according to the GSTM1, GSTT1, and ALDH2 genotypes. HA did not significantly correlate with urinary 8-OHdG in overall subjects. However, the correlation between them showed a statistical significance in individuals with GSTM1-null, GSTT1-null, and ALDH2 *2/*2 genotypes (r = 0.766, p < 0.01). This study shows that the relationship between urinary HA and 8-OHdG concentration is modified by genetic polymorphisms of some metabolizing enzymes such as GSTM1, GSTT1, and ALDH2.

The Influence of Genetic Polymorphisms on Population Variability in Six Xenobiotic-Metabolizing Enzymes

2009 ◽  
Vol 12 (5-6) ◽  
pp. 307-333 ◽  
Author(s):  
Gary Ginsberg ◽  
Susan Smolenski ◽  
Patricia Neafsey ◽  
Dale Hattis ◽  
Katy Walker ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Population Variability ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes
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