Ginkgo biloba extract EGb 761®, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: A randomised, double-blind, exploratory trial

2009 ◽  
Vol 13 (2) ◽  
pp. 183-190 ◽  
Author(s):  
S. Yancheva ◽  
R. Ihl ◽  
G. Nikolova ◽  
P. Panayotov ◽  
S. Schlaefke ◽  
...  
2012 ◽  
Vol 24 (S1) ◽  
pp. S21-S24 ◽  
Author(s):  
Walter E. Müller ◽  
Jeanine Heiser ◽  
Kristina Leuner

ABSTRACTNeuroplasticity, the ability of synapses to undergo structural adaptations in response to functional demand or dysfunctions is increasingly impaired in aging and Alzheimer's disease. EGb761® has been shown in several preclinical reports to increase nearly all aspects of impaired neuroplasticity (long-term potentiation, spine density, neuritogenesis, neurogenesis). While all three fractions of constituents (ginkgolides, flavonoids, bilobalide) seem to be active, the flavonoids and specifically the aglycone isorhamnetin seem to be most relevant.


Drugs & Aging ◽  
2019 ◽  
Vol 36 (5) ◽  
pp. 435-452 ◽  
Author(s):  
Onnita Thancharoen ◽  
Chulaporn Limwattananon ◽  
Onanong Waleekhachonloet ◽  
Thananan Rattanachotphanit ◽  
Phumtham Limwattananon ◽  
...  

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