Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial

Author(s):  
Nazila Garousi ◽  
Babak Tamizifar ◽  
Makan Pourmasoumi ◽  
Awat Feizi ◽  
Gholamreza Askari ◽  
...  
2016 ◽  
Vol 51 (4) ◽  
pp. 456-464 ◽  
Author(s):  
Sara Heebøll ◽  
Martin Kreuzfeldt ◽  
Stephen Hamilton-Dutoit ◽  
Marianne Kjær Poulsen ◽  
Hans Stødkilde-Jørgensen ◽  
...  

2015 ◽  
Vol 36 (4) ◽  
pp. 563-571 ◽  
Author(s):  
Mohsen Razavi Zade ◽  
Mohammad Hosein Telkabadi ◽  
Fereshteh Bahmani ◽  
Behnaz Salehi ◽  
Shima Farshbaf ◽  
...  

2018 ◽  
Vol 120 (2) ◽  
pp. 164-175 ◽  
Author(s):  
Christina N. Katsagoni ◽  
George V. Papatheodoridis ◽  
Panagiota Ioannidou ◽  
Melanie Deutsch ◽  
Alexandra Alexopoulou ◽  
...  

AbstractLifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 (sd11) years, BMI=31·8 (sd4·5) kg/m2, 68 % men) with ultrasonography-proven NAFLD (and elevated alanine aminotransferase (ALT) and/or γ-glutamyl transpeptidase (GGT) levels) were randomised to the following groups: (A) control group (CG), (B) Mediterranean diet group (MDG) or (C) Mediterranean lifestyle group (MLG). Participants of MDG and MLG attended seven 60-min group sessions for 6 months, aiming at weight loss and increasing adherence to MD. In the MLG, additional guidance for increasing physical activity and improving sleep habits were given. Patients in CG received only written information for a healthy lifestyle. At the end of 6 months, 88·8 % of participants completed the study. On the basis of intention-to-treat analysis, both MDG and MLG showed greater weight reduction and higher adherence to MD compared with the CG (allP<0·05) at the end of intervention. In addition, MLG increased vigorous exercise compared with the other two study groups (P<0·001) and mid-day rest/naps compared with CG (P=0·04). MLG showed significant improvements in ALT levels (i.e. ALT<40 U/l (P=0·03) and 50 % reduction of ALT levels (P=0·009)) and liver stiffness (P=0·004) compared with CG after adjusting for % weight loss and baseline values. MDG improved only liver stiffness compared with CG (P<0·001) after adjusting for the aforementioned variables. Small changes towards the Mediterranean lifestyle, along with weight loss, can be a treatment option for patients with NAFLD.


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