Effect of long-term remote ischemic conditioning on inflammation and cardiac remodeling

2019 ◽  
Vol 53 (4) ◽  
pp. 183-191 ◽  
Author(s):  
Kasper Pryds ◽  
Michael Rahbek Schmidt ◽  
Mette Bjerre ◽  
Steffen Thiel ◽  
Jens Refsgaard ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning

scholarly journals Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning

2018 ◽  
Vol 315 (1) ◽  
pp. H150-H158 ◽  
Author(s):  
Marie Hauerslev ◽  
Sivagowry Rasalingam Mørk ◽  
Kasper Pryds ◽  
Hussain Contractor ◽  
Jan Hansen ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Glyceryl Trinitrate ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rat Myocardium ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Human Endothelium

Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. Because of overlapping mechanisms, this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischemic heart disease. We investigated whether long-term GTN treatment modifies the protection by RIC in the rat myocardium and human endothelium. We studied infarct size (IS) in rat hearts subjected to global ischemia-reperfusion (I/R) in vitro and endothelial function in healthy volunteers subjected to I/R of the upper arm. In addition to allocated treatment, rats were coadministered with reactive oxygen species (ROS) or nitric oxide (NO) scavengers. Rats and humans were randomized to 1) control, 2) RIC, 3) GTN, and 4) GTN + RIC. In protocols 3 and 4, rats and humans underwent long-term GTN treatment for 7 consecutive days, applied subcutaneously or 2 h daily transdermally. In rats, RIC and long-term GTN treatment reduced mean IS (18 ± 12%, P = 0.007 and 15 ± 5%, P = 0.002) compared with control (35 ± 13%). RIC and long-term GTN treatment in combination did not reduce IS (29 ± 12%, P = 0.55 vs. control). ROS and NO scavengers both attenuated IS reduction by RIC and long-term GTN treatment. In humans, I/R reduced endothelial function ( P = 0.01 vs. baseline). Separately, RIC and long-term GTN prevented the reduction in endothelial function caused by I/R; given in combination, prevention was lost. RIC and long-term GTN treatment both protect against rat myocardial and human endothelial I/R injury through ROS and NO-dependent mechanisms. However, when given in combination, RIC and long-term GTN treatment fail to confer protection. NEW & NOTEWORTHY Remote ischemic conditioning (RIC) and long-term glyceryl trinitrate (GTN) treatment protect against ischemia-reperfusion injury in both human endothelium and rat myocardium. However, combined application of RIC and long-term GTN treatment abolishes the individual protective effects of RIC and GTN treatment on ischemia-reperfusion injury, suggesting an interaction of clinical importance.

Repeated Remote Ischemic Conditioning Inhibits Cardiac Remodeling with Chronic Heart Failure after Myocardial Infarction in Rats

2013 ◽  
Vol 19 (10) ◽  
pp. S137
Author(s):  
Takehiro Yamaguchi ◽  
Yasukatsu Izumi ◽  
Takanori Yamazaki ◽  
Yasuhiro Nakamura ◽  
Akihisa Hanatani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cardiac Remodeling ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning

Effect of long-term remote ischemic conditioning in patients with chronic ischemic heart failure

2017 ◽  
Vol 112 (6) ◽  
Author(s):  
Kasper Pryds ◽  
Roni Ranghøj Nielsen ◽  
Anders Jorsal ◽  
Mona Sahlholdt Hansen ◽  
Steffen Ringgaard ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ischemic Heart ◽  
Ischemic Heart Failure ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Chronic Ischemic Heart Failure

Fibrinolysis and Remote Ischemic Conditioning: Mechanisms and Treatment Perspectives in Stroke

2021 ◽  
Author(s):  
Andreas Engel Krag ◽  
Rolf Ankerlund Blauenfeldt
Keyword(s):  
Acute Stroke ◽  
Intravenous Thrombolysis ◽  
Vascular Lesions ◽  
Stroke Recurrence ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Neuroprotective Therapy ◽  
Prevention And Treatment ◽  
Endogenous Fibrinolysis

AbstractStroke is a leading cause of death and disability. Intravenous thrombolysis and mechanical thrombectomy have greatly improved outcomes in acute ischemic stroke (AIS). However, only a minority of patients receive reperfusion therapies, highlighting the need for novel neuroprotective therapies. Remote ischemic conditioning (RIC), consisting of brief, intermittent extremity occlusion and reperfusion induced with an inflatable cuff, is a potential neuroprotective therapy in acute stroke. The objective of this narrative review is to describe the effect of RIC on endogenous fibrinolysis and, from this perspective, investigate the potential of RIC in the prevention and treatment of stroke. A systematic literature search was performed in PubMed, and human studies in English were included. Seven studies had investigated the effect of RIC on fibrinolysis in humans. Long-term daily administration of RIC increased endogenous fibrinolysis, whereas a single RIC treatment did not acutely influence endogenous fibrinolysis. Fifteen studies had investigated the effect of RIC as a neuroprotective therapy in the prevention and treatment of stroke. Long-term RIC administration proved effective in reducing new cerebral vascular lesions in patients with established cerebrovascular disease. In patients with acute stroke, RIC was safe and feasible, though its clinical efficacy as a neuroprotectant is yet unproven. In conclusion, a single RIC treatment does not affect fibrinolysis in the acute phase, whereas long-term RIC administration may increase endogenous fibrinolysis. Increased endogenous fibrinolysis is unlikely to be the mediator of the acute neuroprotective effect of RIC in stroke patients, whereas it may partly explain the reduced stroke recurrence associated with long-term RIC treatment.

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