scholarly journals In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships

2008 ◽  
Vol 23 (6) ◽  
pp. 806-818 ◽  
Author(s):  
Aurelian Gulea ◽  
Donald Poirier ◽  
Jenny Roy ◽  
Vitalie Stavila ◽  
Ion Bulimestru ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Metal Complexes ◽  
Antifungal Activities ◽  
Structure Activity Relationships ◽  
Antibacterial And Antifungal Activities ◽  
Structure Activity ◽  
3D Metal Complexes ◽  
Antibacterial And Antifungal

Synthesis of New Series of Phenyldiazene Based Metal Complexes for Designing Most Active Antibacterial and Antifungal Agents

2021 ◽  
Vol 43 (5) ◽  
pp. 578-578
Author(s):  
Khalil Ahmad Khalil Ahmad ◽  
Habib ur Rehman Shah Habib ur Rehman Shah ◽  
Areeba Ashfaq Areeba Ashfaq ◽  
Muhammad Ashfaq Muhammad Ashfaq ◽  
Muhammad Kashif Muhammad Kashif ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Antifungal Agents ◽  
Standard Drug ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Excellent Activity ◽  
Antibacterial And Antifungal

In this study, In Vitro antibacterial and antifungal activities of azo series based on transition metal complexes (Cu2+, Zn2+, Mn2+, Co2+ and Ni2+) with already our reported ligands named as; [(E)-1-(1, 3-dioxolan-2-yl)-2-phenyldiazene] (K-1), [(E)-1-(1, 3-dioxolan-2-yl)-2-(4-methylphenyl)diazene] (K-2), 2-[(E)-phenyl diazenyl]-1H-benzimidazole] (K-3), [(E)-1-(1, 3-dioxolan-2-yl)-2-(4-ethylphenyl)diazene] (K-4), and [(E)-1-(1, 3-dioxolan-2-yl)-2-(2-methylphenyl)-diazene] (K-5) were studied. FTIR 1H-NMR and mass spectrometric techniques were applied for interpretation of synthesized complexes. 4.05-4.07 ppm chemical shift appearance of azo group confirms azo coupling with transition metal complexes. N=N, C-H, C-N and C-O groups are also confirmed by FTIR which exhibited peaks at 1400-1500, 2090-3090, 1100-1180, 1010-1060 and 625-780 cm-1. Furthermore, mass spectroscopic data also gives strong indication for the synthesis of metal complexes. All the newly synthesized complexes were screened for their antibacterial and antifungal activities. Antibacterial and antifungal activity against S. aureus, E.coli and A.niger, A.ustus and C.albican at conc. 250 and#181;g/ml showed excellent activity by K-1 complexes (Co2+, Cu2+, Ni2+), K-5 complexes (Zn2+, Mn2+, Cu2+), K-2 complexes (Co2+, Cu2+, Mn2+) and K-3 (Zn2+, Mn2+, Co2+, Cu2+) as compared to standard drug (Ampicillin). Hence, based on this study, it was concluded that these azo based complexes may act as a platform for designing more active antibacterial and antifungal agents.

In vitro Antibacterial and Antifungal Activities of Ethanolic Extract of Aloe vera Leaf Gel

2006 ◽  
Vol 1 (4) ◽  
pp. 348-355 ◽  
Author(s):  
S. Subramania ◽  
D. Sathish Kumar . ◽  
P. Arulselvan . ◽  
G.P. Senthilkumar .
Keyword(s):  
Aloe Vera ◽  
Ethanolic Extract ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

scholarly journals Phytochemical and Antimicrobial Investigation of Latex from Euphorbia Abyssinica Gmel

2008 ◽  
Vol 3 (9) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Fathy EL-Fiky ◽  
Kaleab Asres ◽  
Simon Gibbons ◽  
Hala Hammoda ◽  
Jihan Badr ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Oleanolic Acid ◽  
Unsaturated Fatty Acid ◽  
Methanol Extract ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Phytochemical Investigation ◽  
Antibacterial And Antifungal ◽  
Micro Organisms

Phytochemical investigation of the latex of Euphorbia abyssinica Gmel (Euphorbiaceae) afforded a new hydroxy unsaturated fatty acid, 8( R)-hydroxy-dec-3( E)-en-oic acid (1), in addition to the four known compounds lupeol (2), β-sitosterol (3), oleanolic acid (4) and β-sitosterol-3- O-glucoside (5). The in vitro antibacterial and antifungal activities of the isolated compounds, as well as the total methanol extract, were studied against different micro-organisms; compound 1 displayed reasonable antifungal activities towards the tested fungi.

Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines

Il Farmaco ◽  
2005 ◽  
Vol 60 (11-12) ◽  
pp. 944-947 ◽  
Author(s):  
F. Zentz ◽  
R. Labia ◽  
D. Sirot ◽  
O. Faure ◽  
R. Grillot ◽  
...  
Keyword(s):  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

scholarly journals Studies on Antibacterial and Antifungal Activities and Minimum Inhibitory Concentrations of Mixed Ligand Transition Metal Complexes of Dibasic Acids as Primary and Heterocyclic Bases as Secondary Ligands

1970 ◽  
Vol 46 (3) ◽  
pp. 365-368 ◽  
Author(s):  
MA Akbor ◽  
MS Islam ◽  
N Akhter ◽  
S Ahmed ◽  
S Siraj
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Diffusion Method ◽  
Antifungal Activities ◽  
Minimum Inhibitory Concentrations ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Mixed ligand (diphenic/ adipic as primary Ligand and quinoline / 8 - hydroxyquinoline as secondary) transition metal complexes of Cobalt (II), Cupper (II), Rhodium (III) and Platinum (IV) ions were synthesized and characterized. Their antibacterial activities against ten bacteria had been evaluated by the disc diffusion method,whilst their antifungal activities against two fungi had been also evaluated by the same method. Minimum inhibitory concentrations (MIC) had been evaluated against six bacteria. The MIC of the complexes against Shigella dysenteriae, Samonella typhi, Streptococcus-β-haemolyticus and Bacillus megaterium were 32 μg/ml; whilst Escherichia coli and Samonella typhi-A the MIC of Co (II) and Pt (IV) were 32μg/ml and those of Cu(II) and Rh(III) complexes were 64 μg/ml. It was found that Cobalt (II), Cupper (II) & Rhodium (III) complexes had pronounced antibacterial and antifungal activities. Platinum (IV) complex had moderate antibacterial and antifungal activity. These values indicate that these are active compounds. Key words: Mixed Ligand; Transition metal; Antimicrobial Activity; Antifungal Activity Minimum Inhibitory Concentrations (MIC) DOI: http://dx.doi.org/10.3329/bjsir.v46i3.9044 BJSIR 2011; 46(3): 365-368

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