Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase

Biological Activity ◽

Growth Factor Receptor ◽

Aurora Kinase ◽

Receptor Kinase ◽

Design Synthesis ◽

Aurora Kinase A ◽

Dual Inhibitors ◽

Epidermal Growth ◽

Association of Aurora kinase A and epidermal growth factor receptor (EGFR) gene copy number with overall survival in KRAS wild-type patients with metastatic colorectal cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.e14056 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. e14056-e14056

Author(s):

E. Dotan ◽

N. J. Meropol ◽

F. Zambito ◽

B. Bove ◽

F. Zhu ◽

...

Keyword(s):

Copy Number ◽

Gene Copy Number ◽

Growth Factor Receptor ◽

Aurora Kinase ◽

Gene Copy ◽

Wild Type ◽

Aurora Kinase A ◽

Egfr Gene ◽

Epidermal Growth ◽

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01391 ◽

2019 ◽

Vol 62 (3) ◽

pp. 1274-1290 ◽

Cited By ~ 7

Author(s):

Romeo Romagnoli ◽

Filippo Prencipe ◽

Paola Oliva ◽

Stefania Baraldi ◽

Pier Giovanni Baraldi ◽

...

Keyword(s):

Synthesis And Biological Evaluation

Growth Factor ◽

Growth Factor Receptor ◽

Biological Evaluation ◽

Receptor Kinase ◽

Design Synthesis ◽

Microtubule Inhibitors ◽

Epidermal Growth ◽

Pyrimidine Analogues ◽

Epidermal Growth Factor Receptor Tyrosine Kinase: A Potential Target in Treatment of Non-Small-Cell Lung Carcinoma

Journal of Environmental Pathology Toxicology and Oncology ◽

10.1615/jenvironpatholtoxicoloncol.2017018341 ◽

2017 ◽

Vol 36 (2) ◽

pp. 151-158 ◽

Cited By ~ 8

Author(s):

Venugopal Vinod Prabhu ◽

Niranjali Devaraj

Keyword(s):

Growth Factor ◽

Receptor Tyrosine Kinase ◽

Small Cell Lung Carcinoma ◽

Growth Factor Receptor ◽

Small Cell ◽

Small Cell Lung ◽

Cell Lung Carcinoma ◽

Epidermal Growth ◽

Faculty Opinions recommendation of Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1090127.543338 ◽

2007 ◽

Author(s):

Nicola Normanno

Keyword(s):

Drug Resistance ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Resistance Mutation ◽

Growth Factor Receptor ◽

Drug Resistance Mutation ◽

Receptor Kinase ◽

Oncogenic Activity ◽

Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism.

10.1016/s0021-9258(18)69195-1 ◽

1988 ◽

Vol 263 (5) ◽

pp. 2230-2237

Author(s):

J G Koland ◽

R A Cerione

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth ◽

Intramolecular Mechanism

Identification and biochemical characterization of novel putative substrates for the epidermal growth factor receptor kinase.

10.1016/s0021-9258(18)42744-5 ◽

1992 ◽

Vol 267 (8) ◽

pp. 5155-5161

Author(s):

F Fazioli ◽

D.P. Bottaro ◽

L Minichiello ◽

A Auricchio ◽

W.T. Wong ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Biochemical Characterization ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors.

10.1016/s0021-9258(18)48332-9 ◽

1987 ◽

Vol 262 (14) ◽

pp. 6921-6930 ◽

Cited By ~ 17

Author(s):

H T Haigler ◽

D D Schlaepfer ◽

W H Burgess

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Phospholipase A2 ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth ◽

Kinase Substrates ◽

Phospholipase A2 Inhibitors

Epidermal growth factor receptor kinase translocation and activation in vivo.

10.1016/s0021-9258(19)83935-2 ◽

1986 ◽

Vol 261 (18) ◽

pp. 8473-8480

Author(s):

D G Kay ◽

W H Lai ◽

M Uchihashi ◽

M N Khan ◽

B I Posner ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines

International Journal of Cancer ◽

10.1002/ijc.11171 ◽

2003 ◽

Vol 106 (1) ◽

pp. 116-124 ◽

Cited By ~ 22

Author(s):

Murielle Mimeault ◽

Nicole Pommery ◽

Jean-Pierre Hénichart

Keyword(s):

Growth Factor ◽

Protein Kinase ◽

Epidermal Growth Factor ◽

Protein Kinase A ◽

Prostatic Cancer ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Apoptotic Effects ◽

Epidermal Growth Factor Receptor Kinase Substrate 8

Encyclopedia of Signaling Molecules ◽

10.1007/978-3-319-67199-4_101132 ◽

2018 ◽

pp. 1603-1603

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Kinase Substrate ◽