Chemical constituents and aldose reductase inhibitory activities of Betula alba bark and leaves

2020 ◽  
pp. 1-5
Author(s):  
Tomoki Iguchi ◽  
Minpei Kuroda ◽  
Nanami Akiyama ◽  
Mariko Hashimoto ◽  
Yoshihiro Mimaki
Keyword(s):  
Aldose Reductase ◽  
Chemical Constituents ◽  
Inhibitory Activities

Evaluation of the chemical constituents, antioxidant and enzyme inhibitory activities of six Yemeni green coffee beans varieties

2022 ◽  
pp. 101552
Author(s):  
Ammar Mohammed Ahmed Ali ◽  
Sakina Yagi ◽  
Ahmed A. Qahtan ◽  
Abdurrahman A. Alatar ◽  
Simone Angeloni ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Green Coffee ◽  
Green Coffee Beans ◽  
Coffee Beans ◽  
Inhibitory Activities

Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase

2008 ◽  
Vol 31 (11) ◽  
pp. 1405-1412 ◽  
Author(s):  
Hyun Ah Jung ◽  
Na Young Yoon ◽  
Hyun Ju Bae ◽  
Byung-Sun Min ◽  
Jae Sue Choi
Keyword(s):  
Aldose Reductase ◽  
Coptidis Rhizoma ◽  
Inhibitory Activities

scholarly journals Synthesis and aldose reductase-inhibitory activities of structural analogues of WF-3681, a novel aldose reductase inhibitor.

1988 ◽  
Vol 36 (4) ◽  
pp. 1404-1414 ◽  
Author(s):  
TAKAYUKI NAMIKI ◽  
YUKIHISA BABA ◽  
YASUTAKA SUZUKI ◽  
MOTOAKI NISHIKAWA ◽  
KOZO SAWADA ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Structural Analogues ◽  
Inhibitory Activities

Synthesis and aldose reductase inhibitory activities of novel N -nitromethylsulfonanilide derivatives

2000 ◽  
Vol 8 (8) ◽  
pp. 2167-2173 ◽  
Author(s):  
Jun Inoue ◽  
Ying-She Cui ◽  
Osamu Sakai ◽  
Yoshikuni Nakamura ◽  
Hiromi Kogiso ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Activities

scholarly journals α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nguyen Phuong Thao ◽  
Pham Thanh Binh ◽  
Nguyen Thi Luyen ◽  
Ta Manh Hung ◽  
Nguyen Hai Dang ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Inhibitory Effects ◽  
Meoh Extract ◽  
Inhibitory Activities ◽  
Isolated Compound ◽  
New Compounds ◽  
Modified Mosher’S Method

As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher’s method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

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