scholarly journals Safety and efficacy of using heat-killed Lactobacillus plantarum L-137: High-dose and long-term use effects on immune-related safety and intestinal bacterial flora

2021 ◽  
Vol 18 (1) ◽  
pp. 127-135
Author(s):  
Hiroko Nakai ◽  
Shinji Murosaki ◽  
Yoshihiro Yamamoto ◽  
Michiko Furutani ◽  
Rumiko Matsuoka ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Bacterial Flora ◽  
High Dose ◽  
Safety And Efficacy

Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia

2005 ◽  
Vol 95 (2) ◽  
pp. 264-266 ◽  
Author(s):  
Sanne van Wissen ◽  
Tineke J. Smilde ◽  
Mieke D. Trip ◽  
Anton F.H. Stalenhoef ◽  
John J.P. Kastelein
Keyword(s):  
Familial Hypercholesterolemia ◽  
High Dose ◽  
Atorvastatin Treatment ◽  
Safety And Efficacy

scholarly journals Long-term safety and efficacy of high-dose controlled-release nifedipine (80 mg per day) in Japanese patients with essential hypertension

2015 ◽  
Vol 38 (10) ◽  
pp. 695-700 ◽  
Author(s):  
Kazuaki Shimamoto ◽  
Masafumi Kimoto ◽  
Yoshimi Matsuda ◽  
Kozue Asano ◽  
Mariko Kajikawa
Keyword(s):  
Essential Hypertension ◽  
Controlled Release ◽  
Japanese Patients ◽  
High Dose ◽  
Safety And Efficacy

Management of difficult to treat severe asthma—what's the evidence?

2016 ◽  
Vol 54 (11) ◽  
pp. 126-129
Keyword(s):  
Severe Asthma ◽  
Systemic Corticosteroid ◽  
Treatment Options ◽  
Corticosteroid Treatment ◽  
High Dose ◽  
Safety And Efficacy ◽  
International Guidelines ◽  
Frequent Use ◽  
Oral Corticosteroids

The management of adults with asthma that remains uncontrolled despite treatment with high-dose therapies poses a challenge to clinicians and patients. National and international guidelines recommend intensification of treatment that typically involves the use of oral corticosteroids.1,2 The risks associated with long-term systemic corticosteroid treatment are well documented, and have led to the search for alternatives. Recent advances in the understanding of the pathology of asthma have prompted the development of other treatment options. Here, we consider the options available for people who require continuous or frequent use of oral corticosteroids and review the safety and efficacy of such treatments.

Long-term safety and efficacy of continuous intrathecal baclofen

2002 ◽  
Vol 44 (10) ◽  
Author(s):  
William M Campbell ◽  
Anne Ferrel ◽  
John F McLaughlin ◽  
Gerald A Grant ◽  
John D Loeser ◽  
...  
Keyword(s):  
Intrathecal Baclofen ◽  
Safety And Efficacy

[18F]Fluoride PET Indicates Reduced Bone Formation in Severe Glucocorticoid-induced Osteoporosis

1998 ◽  
Vol 37 (02) ◽  
pp. 76-79 ◽  
Author(s):  
T. D. Kirchhoff ◽  
W. Burchert ◽  
J. v. d. Hoff ◽  
H. Zeidler ◽  
H. Hundeshagen ◽  
...  
Keyword(s):  
Bone Formation ◽  
Multiple Organ ◽  
High Dose ◽  
Multiple Fractures ◽  
Glucocorticoid Treatment ◽  
Organ Manifestations ◽  
Diagnostic Benefit ◽  
Sharp Syndrome ◽  
18F Fluoride

SummaryA 61-year-old female patient presenting with mixed connective tissue disease (Sharp syndrome), underwent a long-term high dose glucocorticoid treatment because of multiple organ manifestations. Under steroid therapy she developed severe osteoporosis resulting in multiple fractures. A dynamic [18F]fluoride PET study in this patient revealed reduced fluoride influx in non-fractured vertebrae. This finding corresponds to pathogenetic concepts which propose an inhibition of bone formation as major cause of glucocorticoid-induced osteoporosis. In the light of the presented case it seems to be promising to evaluate the diagnostic benefit of [18F]fluoride PET in osteoporosis.

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